Oral solution Detanana 100mg/5ml An Thien treat local epilepsy, alert anxiety disorders (20 tubes x 5ml)

Dosage form Box of 20 tubes x 5ml
Specifications Pregabalin
Ingredient Epilepsy, nerve pain Tam Thoa, sciatica, anxiety

Ingredient

Composition information	Content
Pregabalin	100mg

Uses

Indications

Detanana 100 mg/5 ml drugs are indicated in the following cases:

coordinate with anti -convulsions to treat local epilepsy in adults.

Disorders of anxiety spread.

Pain due to neuritis: peripheral neuritis due to diabetes, neurological pain after herpes.

muscle pain caused by fibrosis.

Pharmacological group: anti -convulsions, painkillers.

Pregabalin is an anti -convulsed and analgesic drug.

Pregabalin has the same structure as the central nerve inhibitor GABA, but is not directly attached to the Gabaa, GABAB receptor, or the receptor of Benzodiazepine, does not increase the response of GABAA in cultured neurons, nor does it change GABA concentration in the mouse brain, does not affect the recovery as well as gaba.

On cultured neurons, long -term use of Pregabalin will increase the density of transport proteins and increase GABA transport speed.

Pregabalin is attached to central nervous tissue with high pressure at the position of α2-Δ (a subunit of the calcium channel depending on the voltage). Although Pregabalin's exact mechanism has not been fully known, the attachment to subunit α2-she may be related to pregabalin analgesic and anti-convulsions effects.

In vitro, pregabalin reduces the release of neurotransmitters dependent calcium such as glutamat, norepinephrin, peptides related to calcitonin and P -regulating genes, can be through the function of calcium channel.

pharmacokinetic

absorption

Pregabalin absorbs quickly in the gastrointestinal tract and the maximum concentration achieved after drinking is 1.5 hours. Oral bioavailability is about 90%.

Food reduces the speed, does not reduce the level of absorption, but this is not clinically significant. Stable concentration is achieved after 1-2 days.

Distribution

Pregabalin is not attached to plasma proteins, the integral distribution after oral drink is about 0.56 liters/kg.

Metabolism

Pregabalin is almost non -metabolized.

Elimination

About 98% are eliminated through the kidneys in a constant form. The average selling time is 6.3 hours. The clearance of pregabalin is proportional to creatinine clearance. Pregabalin is eliminated by hemolysis.

Before taking Oral solution Detanana 100mg/5ml An Thien treat local epilepsy, alert anxiety disorders (20 tubes x 5ml)

How to use

Detanana 100 mg/5 ml Pregabalin is used by oral, divided 2-3 times daily, used or not with food.

Dosage

Supplementing local epilepsy treatment

The starting dose is 150 mg, oral daily, then gradually increases the dose after week depending on the response, up to 300 mg/day and then 600 mg/day.

Landing anxiety disorders

The starting dose of 150 mg daily, can gradually increase the dose after week with a gap of 150 mg to a maximum dose of 600 mg daily.

Pain due to neuritis, after herpes

Adults

Dosage recommended: 150 - 300 mg/day, divided into 2-3 times.

Starting dose: 150 mg/day, can increase to 300 mg/day for 1 week, depending on the efficiency and tolerance. If still does not help after 2-4 weeks of treatment at a dose of 300 mg/day, can increase to a dose of 600 mg/day divided into 2-3 times. The dose exceeds 300 mg/day only for people who are still painful and tolerated with a dose of 300 mg/day, because the potential has many ADR due to high doses.

Diabetes nerve pain

Adults

The starting dose of 150 mg/day, divided into 3 times. The dose may increase in the next 1 week of the recommended maximum dose of 300 mg/day divided into 3 times. Increasing the dose does not increase benefits, but more ADR.

muscle pain due to fibrosis

The starting dose of 150 mg/day, increasing after 1 week depending on the response up to 300 mg/day and 450 mg/day if necessary.

For patients with renal impairment: need dose according to CLCR, specifically as follows

CLCR 30 - less than 60 ml/minute: Start 75 mg/day, up to 300 mg/day, divide 2-3 times.

CLCR 15 - less than 30 ml/minute: Start 25 - 50 mg/day, up to 150 mg/day, divide 2 or use only 1 time.

CLCR

Patients with hemolysis should be received an additional dose of 25 - 100 mg of pregabalin right after each 4 -hour session.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The highest pregabalin dose of 800 mg is not seen clinically significant.

Handling

There is no specific antidote. If indicated, cause vomiting or gastric lavage, maintain airway if needed. Symptomatic treatment, support. The blood part of the blood if indicated (eliminating pregabalin is about 50% in 4 hours).

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Detanana 100 mg/5 ml, you may experience unwanted effects (ADR).

ADR frequency may be affected by the dose or coordinated therapies. In seizure tests, ADR usually occurs more than treatment for pain. Here are the ADRs available on both tests:

Common, ADR> 10/100

Cardiovascular: peripheral edema.

central nervous system: dizziness, sleep, loss of transport, headache.

Digestive system: weight gain, dry mouth.

muscle - bone: Run muscles.

Eyes: blurred vision.

Other: infection.

Uncommon, 1/100

Cardiovascular: chest pain, edema.

Central nervous system: neuritis, abnormal thoughts, fatigue, confusion, refreshment, language disorders, attention disorders, loss of movement, loss/memory loss, pain, dizziness, abnormal sensation/sensory decrease, anxiety, depression, loss of orientation, sleep, fever, personality loss, stimulating body, skin Bruising, itching.

endocrine and metabolism: fluid fluid, reducing blood glucose.

Stomach - intestines: constipation, appetite, flatulence, vomiting, abdominal pain, gastritis.

Genital - Urinary: urinating a lot and urinary incontinence, loss of pleasure, reducing sex.

Blood: platelets.

muscle - Bone: Balance disorders, abnormal gait, muscle weakness, joint pain, muscle jerky, back pain, muscle spasm, muscle vibration, abnormalities, increased CPK, cramps, muscle pain, muscle weakness.

Eyes: visual disorders, vision loss, eyeball, conjunctivitis.

ears: hearing loss.

Respiratory: Sinusitis, shortness of breath, bronchitis, sore throat - larynx.

Other: influenza syndrome, allergic reactions.

Rare, ADR

abscess, acute renal failure, drug dependence (rare), agitation, albuminin, anaphylactic reaction, anemia, angioedema, language disorders, gastritis, apnea ...

Some ADR causes patients to stop the drug. 4% of patients with dizziness or drowsiness must stop treatment. Most cases are blurred by themselves when they continue to treat, less than 1% of patients have to stop treatment. If the visual disorders are prolonged, need for eye exams.

Must stop the drug when muscle disease, or when the serum CPK level increases at least 3 times higher than the normal limit. Must stop the drug when gaining weight, peripheral edema in people who have had heart disease before.

The angioedema rarely occurs, but it usually occurs right after starting therapy Pregabalin; Therefore, before treating patients - with pregabalin, carefully asking for a history of sensitivity and preparing appropriate emergency media.

In addition, it is necessary to notify the patient and the family about the potential of suicide when taking anti -epileptic drugs. Pay attention to signal symptoms such as anxiety, struggle, aggression, attack, opposition, crazy, insomnia and depression. Families need to closely monitor patients.

When stopping the drug, avoiding sudden stop, gradually reducing the dose for at least a week.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Detanana 100 mg/5 ml contraindicated drug in the following cases:

Patients with pregabalin sensitivity or any ingredients of the drug.

Precautions when used

anti -convulsions, including pregabalin, often increases the risk of suicidal thoughts/behaviors. Therefore, patients need to be closely monitored about depression, the tendency to commit suicide, abnormal changes in the treatment process and should be instructed to notify the doctor as soon as the signs appear.

Be cautious when using pregabalin because it can cause peripheral edema. There is no clear combination of peripheral edema with cardiovascular complications (such as hypertension, congestive heart failure and non -kidney or liver.

Pregabalin causes increased body weight related to the dose and time of drug use, however, weight gain is not related to the body mass index (BMI) before treatment, gender, or age, and not due to edema. Although in short -term research, controlled, weight gain does not combine with important clinical changes in blood pressure, but long -term effects on cardiovascular has not been clarified. In addition, pregabalin does not lose blood glucose control.

For patients who have had heart disease before, be cautious when taking the drug because it can increase the risk of heart failure. The drug affects the central nervous system including: drowsiness, dizziness, which can reduce both the physical and mental / patient's mental / mental, so it is necessary to be cautious on driving objects or operating the machine.

Pregabalin can increase CPK and can cause muscle globin - urinary tract (although rare). Patients need to notify the doctor when pain, muscle weakness, increase pain, especially when accompanied by fever and/or fatigue, discomfort. Must stop the drug when there is a manifestation of muscle disease.

Need to stop slowly and reduce pregabalin doses for at least 1 week before stopping the drug to avoid increasing the frequency of epilepsy as for anti -convulsions in general.

Be careful with patients with a history of drug addiction. Monitor the signs of drug abuse (such as greasy, the trend of increasing the dose or the act of searching for drugs). In control clinical studies, the proportion of patients using pregabalin has a refreshing manifestation of 4% compared to 1% in the control group. In studies on patient population, this rate is greater, from 1 - 12%.

When stopping the drug quickly and suddenly, the symptoms of drug dependence such as insomnia, vomiting, headache, diarrhea.

The ability to drive and operate machinery

The drug may have a small or medium effect to the ability to drive and operate machinery. The drug can cause dizziness and drowsiness, so it can affect the ability to drive or use machines. Patients are advised not to drive, operate complicated machines or participate in other dangerous activities until knowing whether the use of drugs affects the ability to perform these activities.

Pregnancy

Research on animal (rats, rabbits) pregnant for pregabalin with a dose to create plasma pregabalin levels (AUC) 5 or more than 5 times the drug concentration in the maximum doses recommended 600 mg/day, see increased rate of malformations in the fetus and the symptoms of poisoning for pregnancy development, including death, development Reproduction in pregnancy.

There is no complete research and good tests in pregnant women. Only use when the potential for maternal benefits is greater than the potential risk for the fetus.

Breastfeeding period

It is unclear whether the drug will be through breast milk or not. Should be cautious when used for breastfeeding women. Rat studies show pregabalin through milk.

Medicinal interaction

Pregabalin increases the concentration/effect of alcohol, anti -diabetes drugs group thiazolidinedion, central neurological inhibitors, methotrimeprazin, selective Serotonin recovery inhibitors.

The concentration/effect of pregabalin is increased by droperidol, hydroxyzin, methotrimeprazin.

The concentration and effects of pregabalin are reduced by ketorolac, ketorolac (small nose), ketorolac (systemic line), mefloquin.

Storage

Store in a dry place, temperature

Expiry date: 24 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

to be out of reach of children.

Read the instructions carefully before use.

Notice immediately to the doctor or pharmacist unwanted effects when using the drug.

If you need more information, please consult your doctor.

This drug is only used by a doctor.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.