Oral solution Guacanyl CPC1HN treat cough caused by bronchial asthma, bronchitis, emphysema (4 blisters x 5 tubes)

Dosage form Box of 4 blisters x 5 tubes
Specifications Terbutalin sulfate, Guiphenesin

Ingredient

Composition information	Content
Terbutalin sulfate	1.5mg
Guiphenesin	66.5mg

Uses

indications

Guacanyl drugs are indicated in the following cases:

Cough caused by bronchial asthma, bronchitis, emphysema, bronchiectasis, acute respiratory infections and other related diseases. Alpha. The main effect of Terbutalin is to relax the bronchial smooth muscles, uterus and peripheral circuits. The drug reduces the respiratory resistance, so it increases the volume of exertion in 1 second. Terbutalin does not directly change the artery oxygen fertilizer. The drug that stimulates adenosin - 3'5 ' - Mono - Mono - Phosphate (AMPC) due to the activation of adenyl cyclase enzyme.

Like metaproterenol and albuterol, terbutalin has a strong stimulating effect on the beta2 receptor of the bronchi, uterine smooth muscle, blood vessels and very little effect on the beta1 receptor of the heart. However, at high doses, Terbutalin may cause heart and central nervous system. Terbutalin sometimes increases heart rate, but it is unknown, it is due to the Terbutalin stimulating the beta1 receptor or the response to the blood pressure changes due to peripheral vasodilation. Guiphenesin has a sputum effect, then stimulates increased secretion in the respiratory tract, increasing the vol As a result, the drug increases the effectiveness of their reflexes and makes it easier to expel phlegm.

Dynamic pharmacokinetics

terbutalin sulfate:

absorb: about 30-50% of the terbutalin sulfate oral dose is absorbed through the digestive tract. After drinking, the breathing effect appears within 30 minutes, the lung function is clinically improved after 1-2 hours, reaching the maximum within 2-3 hours, and the effect time lasts 4 - 8 hours. However, the amount of drug in breast milk is not equal to 1 % of oral dose. The elimination of drugs and metabolites completed within 72 - 96 hours after taking a dose in all forms.

After taking single dose in asthma patients, the sale time is about 3.4 hours.

Guiphenesin:

After drinking, the drug absorbs well from the gastrointestinal tract. In the blood, 60% of the drug is hydrolyzed for 7 hours. The metabolites are no longer active and excreted through the kidneys. After taking 400 mg of guaifenesin, no drug is not detected in the intact form in the urine. The sale time of Guaiphenesin is about 1 hour.

Before taking Oral solution Guacanyl CPC1HN treat cough caused by bronchial asthma, bronchitis, emphysema (4 blisters x 5 tubes)

How to use

oral water -based drugs.

Dosage

Adults: 10 - 15 ml (2 - 3 tubes)/time x 2-3 times/day.

Children:

Children 7 - 15 years old: 5 - 10 ml (1 - 2 tubes)/time x 2-3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

headache, anxiety, tremor, restlessness, nausea, cramping, nervousness, tachycardia, and arrhythmia. Sometimes hypotension occurs.

Test results:

Sometimes there is hyperglycemia and blood lactic acid infection. Beta2 movements can cause hypotension due to potassium re -distribution.

Management:

Case mild to medium: reduce the dose or stop taking the drug

Severe case:

gastric lavage, use activated carbon. Be careful to use beta receptor inhibitors because they are likely to cause bronchospasm. However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

Unwanted effects related to Terbutalin:

Common, ADR> 1/100

Cardiovascular: Increasing heart rate, changing blood pressure, brushing chest drums.

Neurological: headache, restlessness, difficulty sleeping or sleeping, sleeping, weak, hot face, sweating, chest tightness, muscle contraction, tinnitus. vomiting, nausea, uncomfortable taste in the mouth.

Neurological: convulsions, hypersensitivity.

The immune system disorders: Hypersensitivity reactions including angioedema, bronchospasm, hypotension and cardiovascular collapse.

Less or rare reactions: dizziness, headache, diarrhea, vomiting or nausea, abdominal pain, skin rash, urticaria.

The condition of kidney stones has been reported in patients with abuse of preparations containing Guiphenesin.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Guacanyl drug contraindicated in the following cases:

Too hypersensitivity to any component of the preparation or hypersensitivity to other sympathetic neurological medications.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Be careful when using Terbutalin Sulfate for people with diabetes, hyperthyroidism, a history of convulsions, heart disease, including myocardial anemia and arrhythmia, high blood pressure. In sports, it should be noted that the drug can cause a positive reaction when doing anti -doping tests. Do not use drugs for non -intolerance fructose. Note when used for patients with a diet that controls sodium ion.

The effect of the drug on the ability to drive and operate machinery

Using the drug may have side effects such as headache, tremor so it can affect the ability to drive and operate machinery.

Using drugs for women during pregnancy and lactation

Using drugs for pregnant women:

Be cautious when using the drug in the first 3 months of pregnancy.

Use medicine for breastfeeding women:

Terbutalin secretes breast milk but does not affect the emulsion at the dose of treatment.

Recognized cases of transient hypoglycemia in infants, premature babies after the mother was treated with the Beta2 shipping owner.

Drug interaction

Not used simultaneously with sympathetic stimulants, because of the ability to cause complications on the cardiovascular system. However, it is still possible to use sympathetic stimulating drugs to treat bronchospasm for patients who are taking long oral terbutalin. Therefore, when needed to be very careful. Guacanyl should be stopped at least 6 hours before using Halothan anesthetics. The 48 -hour Guahenesin should be stopped before taking this test.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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