Oral solution Notamcef 1200mg Meyer treats symptoms of dizziness, memory impairment, stroke due to ischemia (20 tubes x 10ml)

ATC code: N06bx03

Piracetam (derivative of the amino-butyric gamma acid, GABA) is considered a substance that has a manic effect. Piracetam acts on a number of neurotransmitters such as acetylcholin, noradrenalin, dopamin ... This can explain the positive effect of the drug on learning and improve the ability to perform memory tests. The drug can change neurotransmitter and contribute to improving the metabolic environment so that the nerve cells work well. On experiments, Piracetam has a protective effect against metabolic disorders due to ischemic by increasing brain resistance to oxygen deficiency. Piracetam increases the mobilization and use of glucose without depending on the supply of oxygen, facilitates the pentose path and maintains energy synthesis in the brain. Piracetam enhances the recovery rate after damage due to lack of oxygen by increasing the rotation of inorganic phosphate and reducing glucose and lactic acid accumulation. Under normal conditions as well as without oxygen, Piracetam is found to increase the amount of ATP in the brain due to increased ADP conversion to ATP; This may be a mechanism to explain some useful effects of the drug.

The impact on acetylcholin transmission (increasing the release of acetylcholin) may also contribute to the mechanism of action of the drug. The drug also works to increase the release of dopamine and this may have a good effect on the formation of memory. The drug has no effect on sleep, sedation, resuscitation, analgesic, nervous or neuron and no effect of GABA.

Piracetam reduces the ability to converge platelet and reduces blood viscosity in high doses, in case of abnormal erythrocytes, the drug can cause red blood cells to recover the ability to deform and pass through the capillaries. The drug has anti -vibration effect.

Dynamic pharmacokinetics

Piracetam used by oral is absorbed quickly and almost completely in the digestive tract.

Birth is nearly 100%. Peak concentration in plasma (40 - 60 micrograms/ml) appears 30 minutes after taking a dose of 2 g. The peak concentration in cerebrospinal fluid is achieved after taking the drug 2 - 8 hours.

Absorption of drugs does not change when long -term treatment.

The distribution volume is about 0.6 liters/kg. Piracetam absorbed into all tissues and may be through the blood - brain, placenta barrier and even the membranes used in the kidney. The drug has high concentrations in the cerebral cortex, frontal lobe, top lobe and occipital lobe, cerebellum and bottom partitions.

Semi -selling time in blood is 4 - 5 hours.

Semi -selling time in cerebrospinal fluid is about 6-8 hours. Piracetam is not attached to plasma proteins and is excreted through the kidneys in the form of intact. Piracetam clearance coefficient of the kidney in normal people is 86 ml/min. 30 hours after drinking, more than 95% of the drug is discharged in urine. If the kidney failure, half a lifetime elimination increases: In patients with kidney failure, half -life excreted increased: In patients with complete kidney failure and non -recovery, this time is 48 - 50 hours.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Because Piracetam is discharged through the kidneys, half -life excreted of the drug increased directly to the degree of renal failure and CLCR. It is necessary to be very cautious when taking the drug for patients with renal failure. Need to monitor kidney function in these patients and elderly patients.

Avoid stopping the sudden drug in patients with muscle vibration due to the risk of seizures.

Be cautious in patients with stomach ulcers, with a history of stroke due to hemorrhage, use and drugs that cause bleeding due to increased risk of bleeding. Precautions in major surgery due to potential coagulation disorders.

The excipient of the drug contains glycerin: can cause headaches, stomach pain and diarrhea.

The effect of the drug on the ability to drive and operate machinery

The drug can cause fatigue, sleep, insomnia, dizziness. Avoid use for people who are driving or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women: Piracetam can be through the placenta. Do not use this medication for pregnant people.

Lactating women: Do not use piracetam for nursing mothers.

Drug interaction

can still continue the classic method of alcoholic treatment (vitamins and sedatives) in the case of a person with vitamin deficiency or strong agitation.

There has been a case of interaction between piracetam and thyroid essence when used simultaneously: confusion, stimulation and sleep disorders.

In a patient, prothrombin time has been stabilized by warfarin when using piracetam.