Orelox 100mg Sanofi treatment for infections, sore throat, acute sinusitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefpodoxime

Ingredient

Composition information	Content
Cefpodoxime	100mg

Uses

Indications

Orelox 100mg is indicated in the following cases:

Treatment of bacterial infections in the throat due to Beta hemolytic bacteria group a.

Acute sinusitis treatment.

Treatment of bacterial pneumonia, especially in patients at risk.

After drinking, Cefpodoxime Proxetil is absorbed in the digestive tract and quickly given non -specific esterases into Cefpodoxime, an antibacterial antibiotic.

The action mechanism of Cefpodoxime is based on the inhibition of bacterial cell walls. The drug is still stable in the presence of many beta - lactamase enzymes.

pharmacokinetic

absorption

The ratio of Cefpodoxime Proxetil absorption when a person who is fasting to take a tablet corresponds to 100mg Cefpodoxime is 40 - 50%. Because the absorption of the drug increases when taken with food, so it should be taken during meals.

Distribution

The distribution of Cefpodoxime is 30 - 35L in young people (≈ 0.43L/kg). About 40% Cefpodoxime binds to plasma proteins, mainly albumin. This is a unsaturated type.

Cefpodoxime is widely distributed in pulmonary parenchyma, bronchial mucosa, pleural fluid, tonsils and interstitial fluid.

Metabolism and elimination

After absorption, the main metabolites are Cefpodoxime, the product of the Cefpodoxime Proxetil. Cefpodoxim has been shown to be metabolized at a minimum.

After absorbing Cefpodoxime Proxetil, 80% of Cefpodoxime releases excreted in urine in a constant form. The average selling time for cefpodoxime is 2.4 hours.

Subjects at risk

Cefpodoxim pharmacokinetics parameters only change a little on the elderly with normal kidney function. However, the slight increase of the peak concentration in the serum and the half -life does not need to reduce the dose in this population, except for patients with clearance of less than 40ml/min.

In case of renal failure, corresponding to the clearing of creatinine below 40ml/min, the increase in the sale time and the peak concentration in plasma are forced to reduce the dose to half and use the drug once a day.

In case of liver failure, pharmacokinetics have changed a little but do not need special dose.

Before taking Orelox 100mg Sanofi treatment for infections, sore throat, acute sinusitis (1 blister x 10 tablets)

How to use

Orelox 100mg oral orally. Take medicine 2 times/day, during meals.

Dosage

Dosage varies depending on treatment.

The usual dose is 200 or 400mg per day.

Take the dose of 100mg x 2 times/day in cases of bacterial infections in the throat, the treatment time is 5 days.

Take the dose of 200mg x 2 times/day in the following cases:

Acute sinusitis: In the upper sinusitis, the 5 -day treatment process is proved to be effective.

Acute bronchitis.

Acute drama of chronic obstructive pulmonary disease.

bacterial pneumonia.

Elderly people: No need to adjust the dose if normal kidney function.

Patients with renal impairment: No dose adjustment when creatinine clearance is over 40 ml/min. In the case of creatinine clearance below 40ml/min, it is necessary to reduce the dose to half the daily dose or drop to a dose of the day.

Patients with liver failure: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Orelox 100mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, nausea, vomiting, abdominal pain.

Digestive: Like other broad -spectrum antibiotics, some rare cases of bowel inflammation and bloody diarrhea and fake colitis (the large intestinal disease has the characteristics of fake membrane or viscous mucus, accompanied by constipation and abdominal pain) has been reported.

Liver enzyme increase. allergies: skin rash, itching, rash, angioedema (swelling of the face and neck breakthrough due to allergies) and allergic shock.

Skin: rash, localized puffiness, diverse roses (diseases with symptoms of red skin), Lyell syndrome (peeling skin with cards quickly spreading the whole body).

Neurological: headache, dizziness, beta - lactam antibiotics including cefpodoxime may cause brain disease (including confusion, conscious disorders or abnormal movements), especially when patients overdose or patients with impaired renal function.

Increase the concentration of urea and creatinine in the blood.

Hematology: Reducing or increasing the number of platelets and leukocytes, rarely significantly reduces the number of some types of leukocytes (granulocytes).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Orelox 100mg drug contraindicated in the following cases:

Allergies to antibiotics of cephalosporin.

Porphyrin metabolic disorders.

Be cautious when using

Caution when using cephalosporin in patients with allergies to penicillin. Need to closely monitor the first dose.

Do not treat diarrhea occurs during antibiotic treatment without a doctor's opinion.

Lactam - lactam antibiotics, including cefpodoxime, caused these patients to suffer of enhancement (may include disease, confusion, conscious disorders or abnormal movements), especially when patients overdose or patients with impaired renal function.

Because it contains lactose, this medication should not be used in case of hyperglycemia, glucose and galactose malabsorption syndrome or in case of lactase deficiency (rare metabolic diseases).

Need to notify the doctor if there is a kidney disease. In severe renal failure objects, daily dose should be adjusted based on creatinine clearance.

The drug can cause false positive reactions in some tests (finding glucose in urine, Coombs solution) but does not occur when using methods with oxidase glucose.

The ability to drive and operate machinery

If you feel dizzy or enhancement (may include confusion, conscious disorders or abnormal movements) after taking this medication, do not drive or operate machinery.

Pregnancy

should only take this medication during pregnancy when there is a doctor's opinion.

If you find pregnancy during treatment, consult your doctor to see if you should continue treatment.

Breastfeeding period

can be breastfeeding in case of treatment with this drug.

However, if your baby has digestive disorders (diarrhea, candidiasis) or skin rash, stop breastfeeding or stop taking this medication and quickly consult your doctor.

Drug interaction

Food: A study proved to any food that the bioavailability of Cefpodoxime also increased when drinking at meals.

The change of pH of gastric juice: The increase in the pH of gastric juice as when taking H2 receptor antagonists (Ranitidine) and antacids (aluminum hydroxide, sodium bicarbonate) will reduce the bioavailability of Cefpodoxime, whereas, the reduction of pH of gastric juice (PentagaStstrin) increases the bioavailability of Cefpodoxime. The clinical consequences of this interaction have not been determined.

To avoid possible interactions with other drugs, you must always inform your doctor or pharmacist about all the drugs you are taking.

Storage

Store drugs at a temperature not exceeding 30ºC.

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