Orgametril 5mg MSD tablets for menstruation, menstrual bleeding, hemorrhage (1 blister x 30 tablets)

Dosage form Box of 1 blister x 30 tablets
Specifications Lynesttrenol

Ingredient

Composition information	Content
Lynesttrenol	5mg

Uses

indications

Orgametril 5 mg is indicated in the following cases:

Mutual menstruation; ovulation and abdominal pain due to ovulation; menstruation;

delay menstruation; The drug contains Lynestronol is a synthetic progestagen with the same pharmacological characteristics with natural progesterone hormones. Orgametril has a strong progestagen effect on the endometrium. Taking continuous medication will inhibit both ovulation and menstruation. Orgametril can be used in conditions that require clear progestagen effects.

Dynamic pharmacokinetics

Lynestitrenol are easily absorbed after oral or then metabolized in the liver into Norethisterone with pharmacological activity. The peak concentration of Norethisterone in plasma is achieved within 2-4 hours after taking Lynestronol.

half a lifetime in Norethisterone's plasma after taking Lynestronol is approximately 8 - 11 hours. Lynestronol and metabolites are excreted mainly in urine and a smaller part in the feces.

Before taking Orgametril 5mg MSD tablets for menstruation, menstrual bleeding, hemorrhage (1 blister x 30 tablets)

How to use

should take orgametril tablets by oral with water or other liquid.

Dosage

The first day of the menstruation is counted as the first day of the cycle.

Multi -business

1 orgametril pills/day, on the 14th - 25th day of the cycle.

Menopause and blood blood

2 tablets/day for 10 days. Bleeding usually stops within a few days after the beginning of treatment. Continue treatment in the next 3 cycles with a dose of 1 tablet/day on the 14th - 25th day of each cycle. If the symptoms are not lost during or after treatment, it is necessary to carry out other diagnostic measures.

Selective cases of stilts and minimum or secondary menstrual diseases

Starting with estrogen, for example: 0.02 - 0.05 mg of ethinylestradiol/day for 25 days. Combined with orgametril 1 tablet/day on the 14th - 25th day of the cycle. Most cases will have menstruation within 3 days after stopping the drug.

Start using estrogen on the 5th day of this menstruation, continue until the 25th day and also use in combination with orgametril 1 tablet/day on the 14 - 25th day of the cycle. It is necessary to repeat treatment for at least 1 more cycle.

Endometriosis

1 - 2 tablets/day for at least 6 months.

Selection of endometrial cancer

6 - 10 tablets/day for a long time.

Benign breast disease

1 tablet/day on the 14th - 25th day of the cycle for at least 3 to 4 months.

Sutta inhibitors, ovulation inhibitors and abdominal pain due to ovulation; Sutta

1 tablet/day, it is best to start on the first day but not later than the fifth day of the cycle. Can conduct continuous treatment for months (no day without taking medicine). If abnormal bleeding occurs, the orgametril dose should be increased to 2-3 capsules/day for 3-5 days.

Delayed menstruation

1 tablet Orgametril /day, should start treatment 2 weeks before menstruation. If starting below a week before the menstrual prediction, the orgametril dose must be increased to 2-3 tablets/day. However, in that case, it will not achieve the delay effect for more than 1 week.

The risk of abnormal bleeding will increase if the treatment starts later. Therefore, it is best not to start treatment later 3 days before the menstrual prediction.

Estrogen auxiliary treatment in women in the surrounding and postmenopausal periods to avoid endometriosis

½ - 1 tablet/day for 12-15 days per month, for example: The first 2 weeks each month; Estrogen can be used with the lowest doses that are effective continuously every day without interruption time.

Note: The above dose of orgametril is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In the case of overdose, for example, young children take several tablets at once, and there are no symptoms of poisoning. The possible symptoms are nausea and vomiting. Not necessarily treatment. If necessary, can treat symptoms for patients.

What to do when you forget 1 dose?

Side Effects

When using Orgametril , you may experience unwanted effects (ADR).

From the literature and the survey after circulation, the adverse reactions are reported:

Agency system

(Meddra)*

Adultery effects Sex Skin

Disorders of skin and subcutaneous tissues Sweating, skin pigmentation, itching, acne, increased oily secretion, rash, urticaria , Hairy Supply.

In the continuous treatment regimen with Orgametril often occurs hemorrhage (abnormal bleeding or mild bleeding). Treatment according to the menstrual cycle is rare. In general, the highest rates of hemorrhage occurred in the first two months of treatment; decrease during treatment. In most cases, it is possible to control hemorrhage by increasing the dose temporarily.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Orgametril drug contraindicated in the following cases:

Pregnant or suspected pregnant women.

Severe liver disease such as cholestasis or hepatitis (or a history of severe liver disease, the results of the liver function test do not return to normal), liver cell tumors, rotor syndrome and dubin-johnson syndrome.

Vaginal hemorrhage has not been diagnosed.

Rare diseases are influenced by sexual steroids such as severe itching, cholecystic jaundice, pregnancy herpes, porphyrin metabolic disorders and ear sclerosis, or a history of those diseases. These diseases may occur for the first time or get worse during pregnancy or during treatment with sexual steroids.

There is thrombosis.

Hypersensitivity to active ingredients or any excipients of Orgametril.

Be cautious when used

Orgametril drug contains lactose excipients. Therefore, this drug should therefore be for patients with rare genetic diseases such as galactose tolerance, lactase lactase deficiency or glucose-galactose malabsorption.

Should stop treatment when the results of the liver function test are abnormal.

Melasma sometimes occurs during the use of estrogen and/or drugs containing progestagen, especially in women with a history of melasma during pregnancy. For women who are prone to skin pigmentation, avoid exposure to natural or artificial sunlight.

The use of steroids may affect the results of special tests. Increasing LDL-Cholesterol and HDL-Cholesterol reduction occurs in many patients during orgametril treatment. Sometimes there is a change in liver function parameters, carbohydrate metabolism and hemostasis.

When using Progestagen for a long time, periodic health checks should be used.

Orgametril is determined to have a lightweight masculinity through the influence evaluation on SHBG. This is confirmed by mild signs of masculine status (mainly acne and increased oily secretion) observed in some patients.

Epidemiological survey related to the use of progestagen forms in combination with estrogen has an increase in the rate of thrombosis (VTE, deep veins and pulmonary veins). Although it is not known the clinical involvement of this discovery with Lynestronol without a estrogen component, should stop using orgametril in case of thrombosis. Stopping orgametril should also be considered in the case of long -term immobility due to surgery or due to pathology. Women with a history of thrombosis should be warned about the possibility of recurrence.

Patients with any of the following conditions need regular examination:

Circulatory disorders (or a history of this condition), due to oral contraceptives that contain estrogen/progestagen, are reported to slightly increase the risk of special cardiovascular disorders or brain diseases.

Some severe depression may be worse when using sex steroids.

The ability to drive and operate machinery

Because the phenomenon of dizziness occurs in some patients, it is necessary to be cautious when driving and operating machinery.

Pregnancy

Contraindicated orgametril for pregnant women.

breastfeeding period

There is not enough data on the use of this drug during breastfeeding to assess the risk of harming the baby.

drug interaction

Although the figures are limited, the interaction between Orgametril and other drugs may occur. The following interactions are described when using synthetic progestagen or oral contraceptives, these interactions can also occur when using Orgametril.

Rifamycin, Hydantoin, Barbiturate (including primidone), carbamazepine and aminoglutethimide can reduce the effect of orgametril. In contrast, Orgametril may increase the effectiveness of treatment, pharmacological or toxicity of cyclosporine, theophyline, troleandomycin and some beta-adrenergic blockers. Orgametril can reduce the effectiveness of insulin.

Storage

Store in a dry place, less than 300C, avoid light.

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