Orientfe Oriente Tablets treated the respiratory tract, urinary tract (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Cefpodoxim

Ingredient

Composition information	Content
Cefpodoxim	200mg

Uses

indications

Orientfe 1x10 drug is indicated in the following cases:

cefpodoxim is used in the form of oral to treat mild to medium diseases in the lower respiratory tract, including acute pneumonia is suffering from the community due to streptococcus pneumoniae or haemophilus influenzae sensitive (including the strains of Beta - Latamase) and the acute phase of the racial bronchitis caused by sensitive S. Pneumonia strains H.influenzae or Moraxella (Branhamella, formerly called Neisseria) CatVrhalis, did not give birth to beta - lactamase.

To treat mild and medium infections in the upper respiratory tract (for example, sore throat, tonsillitis) due to sensitive streptococcus pyogenes, cefpodoxim is not a priority selected drug, but rather a replacement drug for the main treatment (eg penicillin). Cefpodoxim also plays a role in the treatment of acute otitis media caused by sensitive strains of S.Pneumoniae, H.influenzae (including the strains of Beta - Lactamase) or B.Catatrhalis.

Cetpodoxim is also used to treat mild and medium -sized urinary tract infections (bladder inflammation) caused by sensitive strains of E.coli, Klebsiella Pneumoniae, Proteus Mirabilis or Staphylococcus Saprophyticus.

A single dose of 200mg of Cefpodoxim is used to treat unprocessed gonorrhea, cervical or anus - rectal of women and gonorrhea in the urethra of women and men, due to strains with or no penicillinase of Neisseria Gonorrhea. Cefpodoxim is also used to treat mild infections that have no complications in the skin and skin organizations caused by Staphylococcus aureus created or not producing penicilinase and sensitive strains of Streptococcus pyogenes.

Pharmacokology

cefpodoxim is the 3rd generation cephalosporin antibiotic. In countries with low antibiotic resistance ratio, Cefpodoxim has high stability against the attack of beta - lactamase, caused by gram -negative and gram -positive bacteria.

In principle, Cefpodoxim has the activity of Gram -positive bridge such as streptococcus pneumoniae), streptococcus streptococcus streptococcus (streptococcus) groups A, B, C, G and with staphylococcus aureus, S.epidermidis or not producing Beta - Lactamase. However, the drug has no anti -staphylococcus staphylococcus aureus - penicillin due to changes in penicillin -mounted proteins (the type of resistance of methicilin staphylococcus augmentation MRSA). This MRSA antibiotic resistance is growing in Vietnam.

Cefpodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has an anti -Gram -negative or pathogenic bacteria such as E.coli, Klebsiella, Proteus Mirabilis and Citrobacter.

However, in Vietnam, these bacteria are also resistant to cephalosporin 3rd generation, which should be noted because it is a risk of failure in treatment.

In contrast to other oral cephalosporins, sustainable cefpodoxim for beta - lactamase by Haemophilus Influenzae, Moraxella Catatrhalis and Neisseria born. However, this comment has not been monitored with systems in Vietnam and the activity of Cefpodoxim is higher than the extent compared to the activity of other oral cephalosporins.

Cefpodoxim has little effect on Proteus vulgaris, Ensobacter, Serratia Marcesens and Clostridium Pertringens. These bacteria are sometimes completely resistant.

Methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas Aeruginosa, Pseudomomas spp. Cephalosporin.

Cefpodoxim on the market is the form of oral cefpodoxim Proxetil (ester of Cefpodoxim). Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esterases, maybe in the intestinal wall, the metabolite of Cefpodoxim is effective.

Dynamic pharmacokinetics

Birth of cefpodoxim is about 50%. The bioavailability of the drug increases when used with food.

Cefpodoxim's waste sale time is 2.1 - 2.8 hours for patients with normal kidney function. The selling time increased to 3.5 - 9.8 hours in people with renal disability. After taking a dose of Cefpodoxim, in healthy adults has a normal kidney function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/ml, 3.9 micrograms/ml for doses of 100mg, 200mg, 400mg.

about 40% Cefpodoxim binds to plasma proteins. The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Orientfe Oriente Tablets treated the respiratory tract, urinary tract (1 blister x 10 tablets)

How to use

should take Cefpodoxim tablets with food to increase the absorption of the drug through the digestive tract.

Dosage

Hangers and children over 13 years old

To treat the acute drama of chronic bronchitis or mild acute pneumonia to the community:

The usual dose of Cefpodoxim is 200 mg/time, every 12 hours, in 10 or 14 days, respectively.

For pharyngitis and/or mild tonsillitis to fit or infection of mild or incomplete urinary tract bacteria:

Cefpodoxim dose is 100 mg every 12 hours, for 5 - 10 days or 7 days, respectively.

For skin infections and mild and medium -complicated skin organizations:

The common dose is 400 mg every 12 hours, for 7-14 days.

To treat unprocessed gonorrhea in men, women and gonorrhea - rectal and endothelial cervix in women:

Use a single dose of 200 mg of Cefpodoxim, followed by oral doxycyclin treatment to prevent chlamydia infection.

Dosage for people with renal failure

Must decrease depending on the degree of renal failure. For patients with creatinine clearance less than 30 ml/min and no blood separation, common dose, for each 24 hours apart. Patients are taking blood apart, taking the dose often 3 times/ week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

No report.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Orientfe 1x10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

general: headache. skin: rash, urticaria and itching.

Uncommon, 1/1000

Allergic reactions: Reaction such as serum with rash, fever and joint pain and anaphylactic reaction.

Skin: Diverse erythema. liver: liver enzyme disorders, hepatitis and temporary jaundice.

Rare, 1/10000

Blood: hyperphaulocytes like eosin, blood disorders.

kidney: interstitial nephritis has recovery.

Central nervous system: Increase activity, be agitated, have difficulty sleeping, confuse, increase tone and dizziness dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Orientfe 1x10 drug is contraindicated in the following cases:

The people who are caught with cefpodoxim or any drug of the drug;

People with allergies to other cephalosporins;

Porphyrin trips disorders.

Be cautious when using

Before starting treatment with cefpodoxim, a thorough investigation of the patient's allergic history with cephalosporin, penicillin or other drugs.

The ability to drive and operate machinery

The drug can cause headaches, dizziness, agitation so it is necessary to be cautious when using the drug for the train driver and operating machinery.

Pregnancy

There is no document about using Cefpodoxim during pregnancy. However, cephalosporin is often considered safe when used for pregnant women.

breastfeeding period

cefpodoxim is secreted through low concentrations. Despite the low concentration, there are 3 problems that occur for breastfed children with cefpodoxim: Disorders of intestinal bacteria, directly acting to the children's body and bacterial culture results will be wrong, if antibiotic when fever.

Drug interaction

Cefpodoxim absorption is reduced when there is anti -acid, so avoid using cefpodoxim along with anti -acid.

Storage

In a dry place, temperatures below 300C, avoid sunlight.

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