Ornisid 500mg reliv treatment for amoeba infection in the intestine and liver (5 blisters x 6 tablets)

Dosage form Box of 5 blisters x 6 tablets
Specifications Ornidazol

Ingredient

Composition information	Content
Ornidazol	500mg

Uses

Indication

Ornisid is an antibacterial substance specified in cases of infections due to sensitive strains or the following parasites:

amoeba infection in the intestine and liver.

Pharmacokinus

ATC code: G01AF06. Group of drugs: amoeba kills and other animal raw materials.

Ornidazol is a derivative 5 - nitro - imidazol with anti -parasite and anaerobic bacteria. In parasites, through the catalyst of ferredoxin, group 5 - nitro of the drug is reduced into toxic mediators to the cell, these substances are associated with the twisted structure of the DNA molecule that broke the fibers, which leads to inhibition of protein synthesis and eventually kill the cells of sensitive microorganisms.

Effective spectrum:

Sensitive strains (S ≤ 4 mg/liter): Anaerobic: Bacteroides Fragilis, Bifidobacterium (60-70%), Bilophilia, Clostridium, Clostridium difficile, Clostrium perfringens, eubacterium (20-30%), Fusobacterium, peptostococcus, prevotellla, prevotellla, prevotellla, prevotellla, prevotellla, Prevotellla, Prevotellla, Prevotellla, Prevotellla, Prevotelllla Porphyromonas, Veillonella.

The anti -drug strains (R> 4mg/liter).

Aerobic gram -positive bacteria: Actinomyces.

Gas bacteria: Mobiluncus, propionibacterium acnes.

Anti -parasitic activity: Entamoeba Histolytica, Giardia Intestinalis, Trichomonas vaginalis.

The anti -drug mechanism: as well as substances in group 5 - other nitro imidazol, ornidazol resistance is caused by low -ferredoxin -containing microorganisms (catalytic protein for reducing group 5 -nitro of drugs) reduces drug reduction, so the sensitivity to drugs is reduced, may need to take high -dose drugs.

Dynamic pharmacokinetics

ornidazol quickly absorbed through the gastrointestinal tract and reached the peak concentration in plasma after about 3 hours. After the oral doses repeat 500 mg every 12 hours, the peak concentration and the bottom concentration in a stable state are 14 and 16 µg/ml. Under 15% is attached to plasma proteins. The drug is widely distributed in tissues and fluid fluids, including cerebrospinal fluid. Ornidazol is metabolized in the liver and is excreted in the urine, mainly in the form of combination and metabolites, and at a lower level through the stool. Ornidazol and metabolites are also eliminated through bile.

Before taking Ornisid 500mg reliv treatment for amoeba infection in the intestine and liver (5 blisters x 6 tablets)

How to use

oral medication, after eating.

Dosage

Adults:

Amoeba disease: Take 500 mg, 2 times daily, for 5-10 days. g, for 1-2 days. The partner must also be treated. Or take 1.5 g, 12 hours before surgery, then take 500 mg, every 12 hours, in 3-5 days after surgery. Children can seriously ≤ 35 kg dose as follows:

Amoeba disease: Take the only dose of 25 mg/kg for 5-10 days. Children with amoeba dysentery can take only 40 mg/kg daily, for 3 days (in case of severe amoeba dysentery and liver abscess using intravenous injection). Due to anaerobic bacteria: Take 20 - 30 mg/kg daily (or use infusion).

Preventive infection due to anaerobic bacteria after surgery: can be taken or intravenous at a dose of 20 - 30 mg/kg, 12 hours before surgery and after surgery at a dose of 20 - 30 mg/kg, every 12 hours in 3 days.

People with renal failure: The elimination of drugs does not change much in people with renal failure, so there is no need to adjust the dose.

Authorized kidney failure: Additional 1 dose before the fertilization. Give an additional dose of 500 mg per day if the daily dose is 2 g or 250 mg per day if the dose is 1g daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Management: There is no specific antidote, in case of cramps can use diazepam.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Ornisid 500 you can experience unwanted effects (ADR):

Side effects arranged by classification and frequency listed in the following table:

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ornisid 500 drug contraindicated in the following cases:

Hypersensitivity to the derivatives of Imidazol or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Be cautious for patients with loss of air conditioning, dizziness, mental disorders. In the event that the leukopenia occurs, the decision to stop treatment depends on the severity of the infection.

The effect of the drug on the ability to drive and operate machinery

Use the drug carefully for drivers or machinery operating because the drug has the potential to cause dizziness and confusion.

Use drugs for women during pregnancy and lactation

Pregnant women: due to lack of clinical and experimental data to avoid drugs for pregnant women.

breastfeeding women: due to lack of clinical and experimental data to avoid drugs for breastfeeding women.

Interactive drug

used at the same time with oral anticoagulants may increase the risk of hemorrhage due to metabolism in the liver.

Ornidazol is reported to reduce the clearance of 5 - flourouracil and increase the toxicity of this substance.

Avoid using alcoholic drinks and alcohol -containing drugs because it can cause antabuse effect (hot, red, vomiting, tachycardia).

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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