Osart-40 Theon Pharma tablet anti-hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Olmesartan Medoxomil

Ingredient

Composition information	Content
Olmesartan Medoxomil	40mg

Uses

indications

Osart 40mg drug indicated in the following cases:

primary hypertension Medoxomil, a drug, is hydrolyzed into olmesartan while absorbing from the gastrointestinal tract.

olmesartan is a selective antagonist AT, Angiotensin II.

Angiotensin II is one of the main causes of hypertension of the Rennin - Angiotens system, these effects include: vasoconstriction, synthesis and release of aldosterone, heart stimulation and kidney's sodium reabsorption.

Olmesatan clases the shrinkage effect of the `` Vascular II's vascular effects selected by Angiotensin II's cohesion into the AT receptor, of the blood vessel plain muscle.

Mechanism of action:

olmesartan is an Angiotensin II type 1 receptor antagonist (AT1) specifically, short blocking the effect of increasing the blood pressure of angiotensin II through the renin-angiotensin-aldosterone system (RAAS).

In the process of stimulating sympathetic or when kidney blood pressure or blood flow decreases, renin is released from the granules of the Jixtaglomeular movement in the kidney. Renin cuts angiotensinogen circulating into angiotensin I, cut by the enzyme converted angiotensin (ACE) into angiotensin II.

Angiotensin II increases blood pressure by increasing the total peripheral resistance, increasing the reabsorption of sodium and kidney water through the secretion of Aldosterone and changing the cardiovascular structure. Angiotensin II is linked to two receptors: AT1 and AT2.

AT1 is a receptor that combines G-Protein (GPCR) as an intermediary that inhibits vascular and aldosterone of angiotensin II.

Angiotensin receptor inhibitors (ARB) are AT1's peptide competitive inhibitors.

ARB is short blocking the ability of angiotensin II to stimulate the effect of cell and cell proliferation. Unlike enzyme inhibitors, ARB does not affect the vasodilation caused by Bradykinin.

The common effect of ARB is to reduce blood pressure.

pharmacokinetics

olmesartan medoxomil is activated quickly and completely by hydrolysis into olmesartan during the absorption process at the digestive tract.

Olmesartan is exported in 2 lines with half -life eliminating the final period of approximately 13 hours. Olmesartan concentration reaches a stable state in 3-5 days and does not occur the phenomenon of drug accumulation in plasma at a dose/ day.

olmesartan reaches the maximum plasma concentration after taking 1-2 hours. Food does not affect the bioavailability of olmesartan.

approximately 35% - 50% of the drug has been absorbed in urine, the rest is excreted through feces and bile. Olmesartan is highly connected to plasma proteins (99%) and does not penetrate the red blood cells.

Before taking Osart-40 Theon Pharma tablet anti-hypertension (3 blisters x 10 tablets)

How to use

Osart 40mg pills of oral film tablets.

Dosage

adults

recommended dose is 20mg/day for adults. The blood pressure parameters improved after 1 week of use and improved clearly after 2 weeks of drug use.

When a patient has a high blood pressure index: a dose of 40mg/day can be increased.

Used into 2 times/day is not as effective than 1 time/day.

No need to adjust the starting dose in elderly patients, for patients with renal impairment (Creatinine clearance

Children (6-16 years old)

The normal starting dose is 10mg, once a day for patients weighing from 20 to

Patients should continue to reduce blood pressure after 2 weeks of treatment, which can increase the dose to up to 20mg, once a day for patients with weight

Do not use olmesartan for children

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? If overdose occurs, symptomatic monitoring and treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using Osart 40mg that you may encounter.

Dizziness, swelling of the face, throat, tongue, lips, eyes, arms, legs, ankles or lower legs, severe diarrhea, weight loss, shortness of breath or difficulty swallowing, hoarseness.

olmesartan can cause other side effects. Call your doctor if you have any abnormal problems when taking the medication.

With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticoid ...).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Osart 40mg drug contraindicated in the following cases:

Contraindicated drugs in the case of patients with allergies or hyperplasheres to the ingredients of the drug.

Caution when using

olmesartan can cause chronic diarrhea and weight loss.

Children:

Babies have a history of exposure to olmesartan in the uterus: If there is an urinary oral hypotension, a blood pressure change or a fertilizer to shorten blood pressure and treat kidney dysfunction.

Children Elderly: Be cautious when using olmesartan for the elderly, should consider reducing the dose.

Patients with weakened renal function: Changing renal function may occur in people sensitive to olmesartan. Patients with kidney stenosis on one side or both sides use olmesartanc may increase creatinine in serum or increase blood urea (bun).

Black skin patients: Olmesartan's hypotension effects in black patients. Need to consider increasing the dose.

The effect of drugs on drivers and operating machinery

should be cautious when used for driving objects and operating machinery.

used for pregnant and lactating women

pregnancy:

Using olmesartan in the last 6 months of pregnancy reduces kidney function, lung damage, bone deformity and fetal death, amniotic fluid.

Other infant lesions include reduced skull production, anuria, hypotension, renal failure and death. When detecting pregnancy, it is necessary to stop Olmesartan as soon as possible.

Breastfeeding period:

It is unknown whether Olmesartan is excreted in breast milk or not, but Olmesartan is secreted at low concentrations in the milk mouse milk.

Due to the ability to adversely affect breastfeeding, it is recommended to stop breastfeeding or stopping the drug, taking into account the importance of the drug for the mother.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Unsonized Aliskiren with Olmesartan in patients with diabetes. Avoid using Aliskiren with olmesartan in patients with renal failure (GFR

Simultaneous use of Olmesartan with Coleselam Hydrochloride reduces contact with the body and reduces the peak concentration of olmesartan in plasma. Use Olmesartan at least 4 hours before using Coleselam Hydrochloride to help reduce drug interaction effects.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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