OSpay Haipharco nasal spray temporarily decreased nasal congestion due to colds (15ml)

oxymetazolin hydrochloride: is an imidazoline conductor that has a sympathetic nerve effect. Oxmetazoline has structured and pharmacological effects similar to naphazoline and xylometazolin. The drug works on the receptors of Alpha - Adrenergic in the arteries of the mucosa each causing the vasoconstriction, leading to a decrease in blood flow and nasal congestion.

In addition, the medicine is clogged. The nose is ventilated for a short time. However, it may be relaxed and congested to some extent. Therefore, avoid long -term use (at most 1 week). Using oxymetazolin eye, conjunctival congestion decreases, but if abuse of the drug can "turn on".

dexamethason: is Fuomethylprednisolon, Glucocorticoid, almost insoluble in water. The glucocorticoids acting by binding to the receptor in the cell, transferring into the cell nucleus and there has affected some translated genes.

Glucocorticoids also have some direct effects, may not be intermediaries attached to the receptor. Dexamethasone has the main effects of glucocorticoids are anti -inflammatory, anti -allergic and immunosuppressive inhibition, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, Dexamethason is stronger than Hydrocortisone, 7 times stronger than prednisolon.

Dexamethason is used, intramuscularly, injected, inhaled or applied on the spot, to treat diseases that corticosteroids are specified (except for adrenal failure) such as bleeding, trauma, surgery, or infection, brain adhesive due to brain tumors, arthritis and soft tissue such as rheumatoid arthritis, short -term treatment of self -acute allergies, such as neurological, acute, hyperplasia. chronic, like bronchial asthma or serum disease.

Using dexamethasone must be combined with the treatment of systemic antibiotics and supportive measures, when needed.

Dexamethason is also used on the spot to apply to the conjunctiva, outer ear or nasal mucosa to treat inflammatory symptoms or allergies in the outer or eye or eye. Eye corticosteroid therapy does not cure the disease, so it is necessary to identify or eliminate the cause of inflammation, if possible.

With pharmacological dose, dexamethasone used body inhibits the pituitary gland release corticotropin (ACTH), causing the adrenal shell to stop the endogenous corticosteroid hormone (causing secondary adrenal implants). If it is necessary to treat with long -term glucocorticoids, only use the drug in the lowest doses possible and usually only used as a supportive drug for other treatment.

When stopping the body therapy with the reasonable dose, it is necessary to reduce the dose gradually, until the function of the hill - Yen - the adrenal is recovered.

pharmacokinetics

oxymetazolin: After the nose of the oxymetazolin hydrochloride solution, the ear canal effect is usually achieved within 5 - 10 minutes, maintain 5-6 hours and then gradually decrease in the next 6 hours. Use at the eye in the eye, the effect of shrinkage occurs for 5 minutes and lasts up to 6 hours. There is no information about the distribution and elimination of the drug in humans.

dexamethason: In general, the corticosteroids are well absorbed from the digestive tract, and are also well absorbed at the position of the drug and then distributed into all tissues in the body. The drug through the placenta and a small amount of milk. After injection, dexamethasone sodium phosphate hydrolyzed quickly into dexamethasone.

When an intravenous injection of 20 mg, the peak concentration appears in plasma after 5 minutes. The drug is also associated with plasma proteins (up to 77%) and mainly albumin. The drug is highly absorbed in the liver, kidneys and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most of the form of non -conjugated steroids. Half a life of plasma is 3.5 - 4.5 hours, but when it comes to effects, often use half a biological life. The half -life of dexamethasone is 36 - 54 hours, so the drug is especially suitable for diseases that need glucocorticoid -acting glucocorticoids.

Precautions when using

The ability to drive and operate machinery

Micro can cause temporary, burning irritation in the nose and throat, nausea, headache, dry nasal mucosa. Therefore, for drivers and machinery should be cautious during use.

pregnancy and lactation

Do not use this drug for pregnant and lactating women.

Drug interaction

Do not coordinate with imao drugs because it can cause hypertension caused by oxymetazoline inhibits the metabolism of amino acids causing vasoconstriction. Because IMAO has the effect of pulling the radio, interactions can still occur after stopping using Imao for up to 15 days.