OVAC 20 VPC treats gastroesophageal reflux - esophagus (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

Indications

OVAC 20 VPC Phar 3x10 is indicated in the following cases:

Gastroesophageal reflux - esophagus.

Stomach - duodenal ulcer.

Zollinger - Ellison syndrome. The acid excretion inhibitors of the stomach due to inhibiting the restoration of the enzyme system hydrogen-kali adenosin triphosphatase (H+/K+-Aatpase), also known as the proton pump in the border cells of the stomach. Omeprazol does not work on acetylcholine receptors or histamine receptors.

With the dose once a day, the drug is maximum for 3-5 days

pharmacokinetic

omeprazol is completely absorbed in the small intestine after drinking for 3 to 6 hours. Biological use after taking the dose repeated about 60%. Food does not affect the absorption of the drug in the intestine. The absorption of omeprazol depends on the oral dose. The drug is highly attached to plasma proteins (about 95%).

Omeprazol is almost completely metabolized in the liver, mainly by the cytochrom P450 enzyme system (Omeprazol is converted by CYP2019 into hydroxy-andprazol and a small part converted by CYP3A into omeprazol sulfon). The non -activity metabolites are excreted mainly through urine (about 80%) and the rest according to feces. The pharmacokinetics of the drug are not clinically changed in the elderly or people with impaired renal function. In people with liver function, the bioavailability of the drug increases. The clearance of the drug decreases in these patients.

Before taking OVAC 20 VPC treats gastroesophageal reflux - esophagus (10 blisters x 10 tablets)

How to use

oral drugs. Should take medicine before breakfast or before going to bed, taking medicine with plenty of water. Take the whole tablet not to bite or chew capsules. To heal long -term scars and avoid recurrent ulcers, it is necessary to completely eliminate H. pylori and reduce or stop using nonsteroidal anti -inflammatory drugs.

Dosage

Treatment of esophagitis due to gastroesophageal reflux - esophagus

The usual dose is 20 - 40 mg, taken once a day, for 4 to 8 weeks; The treatment can then be maintained at a dose of 20 mg once daily.

ulcerative treatment

Take once a day Omeprazole 20 mg (severe cases can be used 40 mg) for 4 weeks if it is duodenal ulcer, for 8 weeks if it is a stomach ulcer. Do not use longer than the above time. Omeprazol therapy reduces acidosis in the stomach, but increases gastrin. However, temporary increase and recovery.

When long -term treatment, it is easy to experience gastric hyperplation. These changes are physiological, benign and recover. The effect of inhibiting proton variable with the area under the concentration - time curve, not just as simple as the drug concentration in plasma. Oral dose 20 mg omeprazol reduces HCl to 2 hours.

For several days, 1 dose daily, the maximum effect will be achieved after 3-5 days. Since then, the acidosis of the stomach has been reduced by 80% on average and the HCI creation due to Pentagastrin stimulation is reduced by 70% after taking the medicine 24 hours.

Prolonged HCI excretion effect; This effect is over after stopping the medication for 5 days. Taking the first 20 mg capsule has been effective in reducing symptoms and in most people with duodenal ulcer within 2 weeks, scarring in people with stomach ulcers and esophagitis with reflux, it takes 4 weeks to heal the scar.

However, the recurrence rate will be high, if H. Pylori is not removed and if not reduced or stopped using nonsteroidal anti -inflammatory drugs (even in the form of a tablet or a slow -released tablet), because non -steroid anti -inflammatory drugs inhibit prostaglandin synthesis for the protection of the stomach lining.

Omeprazol is only one of the drugs in therapy with formula 2 or 3 drugs (proton pump inhibitors, antibiotics, anti -acid drugs). It should be noted that 30% of patients have H. pylori resistant to nitro - imidazol. To kill H. pylori, the commonly used drug is amoxycilin (or tetracyclin) + Metronidazol (or Tinidazol) for 10 days. Should drink omeprazol simultaneously with amoxicilin, because if you use omeprazol first, it will reduce the effect of both of these drugs. Therapy using 3 drugs often causes more unwanted effects than using 2 drugs, but in both cases, the unwanted effect is light. When choosing the treatment plan, it is necessary to take into account the antibiotic resistance of H. Pylori. Therefore, H. pylori culture. If high doses are taken, do not stop the drug suddenly but must decrease gradually.

Treatment of Zollinger - Ellison syndrome

Take 60 mg once a day (20 - 120 mg daily), if the dose is higher than 80 mg, divide 2 times daily. The dosage should be calculated for specific cases and the therapy may last depending on the clinical requirements. Do not stop the drug suddenly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using OVAC 20 VPC Phar 3x10, you may experience unwanted effects (ADR).

Common: headache, drowsiness, dizziness, nausea, vomiting, abdominal pain, constipation, bloating.

Less: insomnia, fatigue, urticaria, itching, rash, temporary liver enzyme increase.

Rare: sweating, peripheral edema, hypersensitivity (including angioedema, fever, anaphylaxis), blood disorders (such as granulocytosis, leukopenia, platelet reduction), confusion with recovery, excitement, depression, hallucinations in serious patients, visual disorders, large breasts in men, stomatitis, mouth dryness, hepatitis, jaundice, nephritis, nephritis. The risk of cancer caused by gastrointestinal pH drugs causes bacteria to develop nitrosarnin feed.

Instructions on how to handle ADR

Stop using and consulting the doctor: When the effects are unwanted or become worse.

Notify the doctor the unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

OVAC 20 VPC Phar 3x10 contraindications in cases of hypersensitivity to omeprazol or other ingredients of the drug.

Be cautious when using

Eliminate the possibility of malignant tumors in the stomach before giving stomach ulcers using omeprazol.

The ability to drive and operate machinery

The drug can cause dizziness and drowsiness. So do not use for train drivers and operate machinery.

Pregnancy

should not use medication for pregnant women, especially in the first 3 months of pregnancy, nursing mothers. Although experiments do not see omeprazol has the ability to cause deformities and toxic to the fetus, but should not be used for pregnant women, especially in the first 3 months.

Breastfeeding period

Drug interaction

omeprazole may increase the level of Ciclosporin in the blood. Omeprazole increases the effect of antibiotics to eradicate H. pylori. Omeprazole inhibits the metabolic of drugs metabolized by the enzyme in the liver's cytochrom P450 and can increase the concentration of diazepam, phenytoin and warfarin in the blood. The drug increases the anticoagulant effect Dicoumarol, the drug that reduces nifedipine metabolism at least 20% and may increase the effects of nifedipine. Clarithromycin inhibits omeprazol metabolism and doubled Omeprazol levels.

Storage

Leave the medicine in a cool dry place, temperatures below 30 ° C, avoid light.

To be out of reach of children.

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