Ovumix Elea vaginal placement treats vaginitis, cervical vaginal irradiation (1 blister x 6 tablets)

Dosage form Box of 1 blister x 6 tablets
Specifications Metronidazole, miconazole, neomycin, gotu kola, polymyxin-b-sulfat

Ingredient

Composition information	Content
Metronidazole	300mg
Miconazol	100mg
Neomycin	48.8mg
Gotu Kola	15mg
Polymyxin-b-sulfat	4.4mg

Uses

Indications

Ovumix 400 mg drug is indicated for local treatment for cases: Specific vulva - vaginal inflammation or not specific, especially when combined with vaginal lesions; vulvar inflammation , vaginitis, bacterial infections or vaginal burning - cervical, candidiasis, trichomonas, discharge.

Pharmacology

pharmacokinetics

miconazole nitrate

In case of using vaginal placement, the epithelial surface is like a barrier that limits the absorption of the drug. The body absorption of miconazole after vaginal placement does not exceed 1.3%. Miconazole penetrates the vaginal periwares and maintains for more than 4 days after placing it. When used on the spot, Miconazole is metabolized through the liver and half -life eliminated about 1 hour.

metronidazol

When using vaginal drugs, Metronidazole absorbs and distributed in plasma as well as in other tissues with very low concentrations. Drugs absorb and release poorly when placing the vagina, at a dose of 500 mg, the maximum concentration in the serum is achieved after 9 to 13 hours of vaginal placement, and the plasma concentration is 10 times lower when used. The dose of 37.5 mg is used for concentration of treatment required in tissue equivalent to the dose of oral 500 mg and the release effect of the drug in the vaginal epithelium is equivalent to oral absorption.

The drug is metabolized through the liver by the oxidation process into hydroxy and acid metabolites. Metronidazole is constant and some metabolites are excreted in different ratios in human urine and test animals. After drinking, 75% are eliminated through the kidneys. Half life in plasma is about 8.5 hours after drinking. The drug is also well distributed into the tissues, reaching high concentrations in cerebrospinal fluid. Metronidazole can also be excreted in breast milk with concentrations similar to blood, saliva and semen.

polymyxin b sulfate

polymyxin b, sulfate must not be absorbed through the gastrointestinal tract, except in newborns. The drug is not absorbed when the skin is intact.

neomycin sulfate

Absorbing drugs may increase when the mucosa is inflamed or damaged. The drug is also absorbed by peritoneal, respiratory, bladder, wounds and inflamed skin. When absorbed, Neomycin excreted quickly through the kidneys in the form of activity. Half life of the drug is about 2-3 hours.

Gotu Kola (Herba Centellae Asiaticae)

Centella acts on the spot, there is no significant absorption in the position.

Before taking Ovumix Elea vaginal placement treats vaginitis, cervical vaginal irradiation (1 blister x 6 tablets)

How to use

Put gently and deep into the vagina. Use for at least 5 to 10 days.

Dosage

should start with a vaginal dose of 1-2 capsules daily. When symptoms improve, continue with the dose of 1 tablet vagina per day, before going to bed, until the disease is gone.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In case of overdose, treatment support at the nearest hospital.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Ovumix 400 mg , you may experience unwanted effects (ADR).

Rare, 1/10000

In place: burning, itching and irritating vaginal vulva.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ovumix drugs contraindicated in the following cases:

Hypersensitivity to iMidazol derivative or any ingredient of the drug.

The first three months of pregnancy.

breastfeeding women.

Patients with hematological disorders.

Patients with diseases of the central nervous system.

Precautions when using

Prisable when used for patients with severe liver dysfunction.

Unused before intercourse, the use of drugs makes it difficult to conceive. The drug does not prevent the transmission of sexually transmitted diseases. The composition of vaginal drugs can make condoms and less durable vaginal diaphragm.

The ability to drive and operate machinery

No information.

Pregnancy

Contraindicated in the first 3 months of pregnancy.

Breastfeeding period

Contraindications for breastfeeding women.

Drug interaction

Avoid vaginal douching with alkali substances.

Because the drug is absorbed slowly when used on the spot, it is impossible to eliminate systemic interaction. Do not recommend using: alcohol (antabuse effects), warfarin, cooumadine (increasing anticoagulant effects) and disulfiram.

Storage

Storage at room temperature 15 - 30 ° C, avoid heat (above 30 ° C).

Other drugs

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