Oxacillin IMP 500mg Imexpharm Treatment of infection (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Oxacillin

Ingredient

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Composition information	Content
Oxacillin	500mg

Uses

indications

Oxacillin IMP drugs are indicated in the following cases:

Oxacilin is used in the treatment of staphylococcus infections resistant to benzyl penicillin. However, only in cases of identifying penicillinase bacteria are still sensitive to the drug. Infections associated with intravascular catheter. Learning

Pharmacological group: antibiotic penicillin group penicillinase.

ATC: J01CF04.

Operating mechanism:

Oxacilin is semi -synthetic penicillin antibiotic, belonging to the group of penicillins that are not inactive by penicillinase. Like other beta-lactam antibiotics, Oxacilin has bactericidal effects according to the synthetic inhibition mechanism of bacterial cell wall.

antibacterial spectrum:

Aerobic Gram -positive, Gram -positive bacteria and some aerobic gram -negative bacteria. In vitro, Oxacilin acts on staphylococcus aureus and S. Epidermidis secretion and no secretion of penicilinase, S. Pyogenes (Streptococcus beta group A), S. Agalactiae (Streptococcus group B), Streptococcus Group C and G, S. Pneumiae Streptococcus Viridans.

Drug resistance:

The drug has no effect on Gram -negative bacteria, anaerobic bacteria, Mycobacteria, Mycoplasma, Rickettsia, mushrooms, viruses, Enterococcus (including E. Faecalis). Up to now, many staphylococcus strains have appeared.

Dynamic pharmacokinetics

Oxacilin is absorbed quickly but not completely (33%) through the digestive tract. Food reduces the speed and level of absorption of the drug. With a dose of 500 mg, the maximum concentration in plasma reaches about 3-4 micrograms/ml within 0.5 - 2 hours after drinking. Oxacillin metabolizes partially in the body to form and have no effect. High -linked drugs with plasma proteins (about 90%). Oxacilin is widely distributed in the body, found in the amniotic fluid, fetus and breast milk. Oxacilin excreted quickly through the urine in a constant form and metabolites worked, mainly through the renal tubules and filter in glomeruli. Serum disposal time is about 0.3 to 0.8 hours in patients with normal renal function and longer in kidney disabled people.

Before taking Oxacillin IMP 500mg Imexpharm Treatment of infection (3 blisters x 10 tablets)

How to use

Oxacillin IMP orally.

Take the whole pill with a little water.

Due to the food that affects the absorption of oxacilin through the gastrointestinal tract, it is advisable to take at least 1 hour before or 2 hours after the meal.

Do not use oral medication when starting to treat severe infections or treat people with nausea, vomiting, stomach relaxation, not relaxing the mind (causing bulging esophagus) or increasing intestinal motility.

Dosage

Adults:

Common dose:

Oral 500 mg - 1 g (2 - 4 Oxacillin IMP 250 mg or 1 - 2 Oxacillin IMP 500 masks)/time, 4-6 hours/time. Maximum 6 g (24 tablets Oxacillin IMP 250 mg or 12 Oxacillin IMP 500 mg)/day.

Premature and newborn babies: Using other forms of preparation more suitable.

Children weighing less than 40 kg: Take 12.5 - 25 mg/kg body/time, 6 hours/time.

Children weighing 40 kg or more: Used as adult dose.

or the dose is calculated in the form of preparation:

Dosage calculated in the form of preparation inappropriate Hour/time Big

Treatment time: Oxacillin treatment time depends on the type and severity of the infection and is determined depending on the clinical and bacterial testing response.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms and overdose signs:

There is no sign of overdose, no overdose of the drug.

How to handle poisoning:

Actively monitor for timely management measures.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Oxacillin IMP, you may experience unwanted effects (ADR) such as:

Oxacillin's undesirable effect is similar to other penicillinase -resistant penicillin.

After drinking, the reaction in the digestive tract is more.

Common (ADR> 1/100):

Digestive: Nausea, diarrhea

Blood: Eosin hypernagus, leukopenia, platelets.

Skin: urticaria.

allergies: Anaphylaxis reaction.

Periodically assess the kidney, liver and blood function while long -term treatment with oxacilin. Because blood adr occurs during treatment with penicillinase -resistant penicillin, the number and white blood cells must be tested before starting treatment and 1-3 times a week during treatment.

In addition, urine tests must be done, periodically quantifying creatinine, AST (GOT) and ALT (GPT) in the front and pre -treatment serum.

If there is an eosinophilia, urticaria or serum increased hyperglycemia has no cause during oxacillin treatment, other anti -bacterial therapy instead of.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Oxacillin IMP drugs are contraindicated in the following cases:

Anaphylaxis reactions in the first treatment with any penicillin or cephalosporin.

Be cautious when used

oxacilin can cause allergies like penicillin so it is necessary to comply with the usual caution of penicillin therapy. Before starting treatment with oxacilin, it is necessary to carefully investigate the previous allergic reactions, especially hypersensitivity reactions to penicillin, cephalosporin or other drugs.

The drug can affect liver, kidney and blood function, need to check the liver, kidney, blood formula before and periodically during treatment.

The effect of the drug on driving and operating machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

pregnancy:

Determined oxacilin through the placenta. Safety when using oxacilin for pregnant mothers has not been confirmed, so it is only used when necessary.

breastfeeding period:

whether the drug is distributed in milk, it is unclear whether or not it is harmful to the child. Consider when taking medicine for women who are breastfeeding or should not breastfeed when taking the drug.

Medicinal interaction

Timeless with bactericidal antibiotics such as tetracyclin reduces the effect of oxacilin.

Probenecid increases serum oxacillin levels, maybe due to probenecid, reducing the excretion of drugs through the renal tubules.

Penicilin can slow down methotrexat excretion from the body.

The cavalry of the drug:

The mixture of beta-lactam antibiotics with aminoglycosides loses the effect of beta-lactam, reducing the concentration of aminoglycosides in serum. Therefore, do not simultaneously use oxacilin with aminoglycosid antibiotics. If you have to coordinate in treatment, do not use the same time.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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