Oxypod 5 OPV tablets treat a lot of urine, night urine, non -autonomous urine (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Oxybutynin

Ingredient

Composition information	Content
Oxybutynin	5mg

Uses

Indications

Oxypod 5 drugs are indicated in the following cases:

Excessive urination treatment, unable to urinate, unable to control because of the disorders in the bladder due to nerves. In case, there is anti -acetylcholine effect at the Muscarinic receptor similar to atropine, and has a direct anti -spasm effect like papaverin.

Oxybutynin does not have the effect of nicotinic receptor resistance (that is, it does not prevent the effect of acetylcholin door in place in place of neurosurgery - skeletal muscle or in plant nerves).

The anti -spasms of the drug have been shown on the muscles of the bladder, small intestine and colon of many different animals. However, unlike papaverin, oxybutynin has very little or no effect on blood vessel smooth. On people with no self -control bladder disease.

Oxybutynin increases the bladder capacity, reduces the frequency of non -inhibiting spasms of the bladder smooth muscle and slows the want to urinate. Therefore, Oxybutynin reduces the level of emergency urination and the frequency of both active and passive urination. But the effect of the drug indicates that the bladder is not inhibited due to nerve damage compared to the bladder not inhibited due to reflexes.

pharmacokinetics

After taking the form of drugs quickly, the highest oxybutynin concentration in plasma is achieved within 1 hour. The drug is initially metabolized through the liver, so bioavailability only reaches 6%. Half life of the drug is about 2-3 hours. Food does not affect the speed, level of absorption and metabolism of oxybutynin.

Oxybutynin starts to work within 30-60 minutes and the strongest effect within 3-6 hours after drinking, anti -spasms can last 6-10 hours. Oxybutynin into breast milk and can pass the blood -brain barrier. Oxybutynin is metabolized by the cytochrom P450 enzyme system, mainly by isenzy CYP3A4 in the liver and intestinal wall. Desethyloxybutynin metabolites still work. Under 0.1% of the dosage deduction in the form of unchanged urine.

Before taking Oxypod 5 OPV tablets treat a lot of urine, night urine, non -autonomous urine (3 blisters x 10 tablets)

How to use

Oxypod drugs are taken orally.

oral medications, should stop each batch to monitor if you need to continue taking the drug and to minimize drug resistance.

Dosage

Adults

Initial dose: Take 2.5 mg, 3 times/day, the dose may increase if the minimum dose is required.

Normal dose: 5 mg/time, 2-3 times/day. Maximum dose of 5 mg/time, drink 4 times/day.

Elderly

Initial dose: Take 2.5 mg/time, taken 2 times a day, the dose may increase if the minimum dose is required.

Normal dose: 5 mg/time, 2 times/day, especially for people with light weight.

Children over 5 years old

Initial dose: Take 2.5 mg, 2 times/day, the dose may increase if the minimum dose is needed.

Recommended dose: 0.3 ~ 0.4 mg/kg/day.

Children from 5 - 9 years old

Maximum dose of 2.5 mg/time, 3 times/day.

Children from 9 - 12 years old

Maximum dose of 5 mg/time, 2 times/day.

Children aged 12 and older

Maximum dose of 5 mg/time, 3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms on the central nervous system include tremor, irritability, delirium, excitement, hallucinations, convulsions.

Cardiovascular symptoms: flushing, tachycardia, hypertension or hypotension, arrhythmia.

Fever, nausea, vomiting, dehydration, urination may occur.

Serious overdose can cause paralysis, respiratory failure, coma.

Treatment

includes symptomatic treatment and supportive treatment. After an overdose of Oxybutynin, gastric lavage immediately or causing vomiting. Contraindicated to cause vomiting in money coma, convulsions or mental disorders. Activated carbon and bleach can be used. Can be intravenous physostigmin.

Treatment of ice fever or other cooling measures.

Maintain artificial respiration if the patient has paralysis of respiratory muscles.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Oxypod® 5, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: dizziness, dizziness, headache, confusion, chicken sleep, insomnia, irritation, weakness, dry skin, rash.

digestive: dry mouth, nausea, vomiting, constipation, diarrhea, gastroesophageal reflux - esophagus, indigestion, flatulence, abdominal pain.

Eyes: dry eyes, blurred vision.

Urinary tract: urination, cystitis, urinary tract infections.

Respiratory: cough, dry nose and sinus mucosa, rhinitis, sinusitis, sore throat, bronchitis, influenza syndrome.

circulating: vasodilation or hypertension.

bone - joints: joint pain, back pain.

Uncommon, 1/1000

Body: Anorexia, fever, blushing face, angioedema, weakness.

Eye: Reduction of vision, pupil relaxation, glaucoma, Mi body paralysis.

digestive: indigestion, reducing gastrointestinal motility.

Central nervous system (when using high doses): agitation, loss of orientation, hallucinations, convulsions (high risk in children). circulating: fast heartbeat, arrhythmia. Skin: Sensitive light.

Endocrine: impotence, reducing milk excretion.

Heavy allergic reactions: rash, urticaria, other skin reactions.

Reduces odor secretion, leading to a hot feeling and fainting in a hot environment.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Oxypod 5 contraindications in the following cases:

Hypersensitivity to the drug or any ingredient of the drug.

Gleloms of closed angle or narrow room corner.

Urine disease congestion, urination.

Myasthenia.

Ofclaying or semi -obstruction, stagnant stomach, loss of intestinal tone, intestinal paralysis, severe ulcerative colitis, poisoned colon aneurysm.

Elderly or weakness has a reduced intestinal tone.

Bleeding in people with unstable cardiovascular condition.

Do not use for children under 5 years old because they have not determined safety and effectiveness.

Precautions when using

oxybutynin chloride should be used cautiously in the elderly and children (these people may be more sensitive to the effect of the drug) and in patients with self -management neuropathy (such as people with Parkinson's disease), liver, kidney failure and serious intestinal motility disorders.

Gastrointestinal disorders

Cholinergic drugs may reduce bowel motility. Caution should be used in patients with gastrointestinal obstruction disorders, intestinal tone and ulcerative colitis.

anti -cholinergic drugs should be used carefully in elderly patients due to the risk of cognitive decline. Because of the anti -cholinergie effect of oxybutynin chloride, serious Atropin symptoms may occur during treatment with Oxybutynin, especially in children. The severity of these symptoms may require adjusting or stopping treatment.

Oxybutynin chloride can worsen tachycardia (and due to hyperthyroidism, congestive heart failure, arrhythmia, coronary artery disease, hypertension) cognitive disorders and symptoms of prostate fertility.

Effects on the central bodies of anti -cholinergic drugs (such as hallucinations, agitation, confusion, chicken sleep) have been reported; for special monitoring in the first months after starting treatment or increasing dose; Consider stopping the drug or a decrease in the dose if it works on the central nervous system of the progressive cholinergic drug.

Because Oxybutynin can cause narrow angle glaucoma, patients should be advised to the doctor immediately if they find sudden loss of vision or eye pain.

Oxybutynin can reduce sweat: in high temperature environments can lead to heat.

If there is an infection of the urinary tract, it is recommended to start appropriate antibacterial therapy.

Oxybutynin chloride is considered unsafe for patients with porphyrin metabolic disorders due to drugs that have been shown to cause porphyrin metabolism disorders in animals and in vitro.

Long -term use can lead to an increase in tooth decay, periodontal or oral candidiasis due to reduction or inhibition of saliva secretion. Regularly check teeth during long -term treatment.

Special care should be taken care of patients with hernias for esophageal/gastroesophageal reflux and/or those who are using them simultaneously (such as bisphosphonate) that can cause or worsen esophagitis, such as anti -cholinergic drugs that can worsen this condition.

Patients with rare genetic problems are galaciose, Lactose Lapp or Glucose - Galactose should not use this drug.

Children

Oxybutynin Chloride is not recommended for children under 5 years old because of the safe and incomplete treatment data.

Evidence of the limited use of oxybutynin in children's bedwetting single night symptoms (not related to spasms).

In children over 5 years old, Oxybutynin chloride should be used caution because children may be more sensitive to the effect of the drug, especially unwanted reactions on the central and mental nervous system.

The ability to drive and operate machinery

must be cautious when driving or operating the machine because the drug can cause drowsiness or blurred vision.

Pregnancy

There is no enough data on the use of oxybutynin during pregnancy. Animal studies have shown small reproductive toxicity. The animal research guard is not enough to reflect the effects on pregnancy, embryo/fetal development, birth or development after birth. The hidden risks to humans are unknown. Oxybutynin should not be used during pregnancy unless really necessary.

Breastfeeding period

Oxybutynin is excreted into breast milk. It is not recommended to use oxybutynin during breastfeeding.

Medicinal interaction

should be cautious when using oxybutynin simultaneously with other anti -cholinergic drugs because it can lead to confusion in older people.

Oxybutynin's anti -cholinergic activity is increased when used simultaneously with other anti -cholinergic drugs or anti -cholinergic drugs such as amantadin and anti -Parkinson anti -cholinergic drugs (such as biperiden, levodopa), antihistamine, anticonvulsants (such as phenothiazine, butyrophenone, clotyrophenone, clotyrophenone) Digitalis, three -round anti -traced drugs, atropine and related compounds such as anti -spasms similar to atropine and dipyridamdl.

Due to reducing stomach peristalsis, Oxybutynin can affect the absorption of other drugs. Oxybutynin may also reduce the effects of the digestive tract of Metoclopramid and domperidon.

Oxybutynin is metabolized by Cytochrom P450 Isoenzym CYP 3A4. Concomitant use with CYP 3A4 inhibitors can inhibit oxygenbutynin metabolism and increase exposure to oxybutynin. It should be noted when using azol group simultaneously (eg ketoconazole) or macrolid antibiotics (eg erythromycin) with oxybutynin.

Oxybutynin may be opposed to peristalt and peristalsis therapies.

Nitroglycerin's solubility ability using lines under the tongue may be reduced due to dry mouth. Patients using nitroglycerin under the tongue should know they should moisten their mouth with tongue or with some water before use.

Simultaneous use of oxybutynin with otraconazole has led to 2 times an increase in plasma oxybutynin levels, but only increased by 10% of active metabolites. This interaction is probably less clinical.

Concentrated with enzyme inhibitors can reduce the effectiveness of enzyme inhibitors cholinesterase.

Patients need to be notified that alcohol can increase drowsiness caused by anti -cholinergic drugs such as Oxybutynin.

Storage

At temperatures below 30 ° C, in a dry place, avoiding light.

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