Oxytocin medicine 5 IU/ml indicated in urging, supportive treatment when miscarriage is incomplete (20 blisters x 5 tubes x 1ml)

Dosage form Box of 20 blisters x 5 tubes x 1ml
Specifications Oxytocin

Ingredient

Composition information	Content
Oxytocin	5iu

Uses

indicated

Oxytocin is indicated to cause or increase uterine spasms.

Prenatal use:

End of birth

Use oxytocin to push to be indicated for the case of giving birth or about to have hypertension (for example: pre-eclampsia, eclampsia or kidney-blood disease), infant red blood cells, mothers with diabetes or gestational diabetes, pre-birth or prenatal hemorrhage, early rupture without natural spasms. Using oxytocin to end birth can specify cases of prolonged pregnancy (pregnancy longer than 42 weeks). It is also possible to urge birth in the event of stillbirth or underdeveloped fetus.

Increase uterine spasm

In the early stages or second stage of labor, oxytocin intravenously can be used to increase uterine spasm if the labor is prolonged or inert uterine due to dysfunction.

Use after birth:

Control postpartum hemorrhage and hypotension.

Other uses:

Used as a supportive therapy in handling incomplete or inevitable miscarriage.

Used in diagnosis:

To assess the respiratory function of the uterus in cases of high risk pregnancy (use test of oxytocin evaluation).

Pharmacology

Code ATC: H01BB02

Inn: Oxytocin

The pharmacological and clinical properties of oxytocin are similar to the principle of the operation of the natural oxygen of the pituitary after the pituitary gland. The uterus carries specific receptors with oxytocin, belonging to the group of receptors associated with G-Protein. Oxytocin stimulates uterine smooth spasm by increasing intracellular calcium concentration, imitating the spasm of normal natural delivery and temporarily hindering the circulation through the uterus. The intensity and time of uterine contractions increase and open the cervix. The amount of oxytocin receptor is also a response to the uterus with oxytocin increased during pregnancy, reaching the peak at birth. Oxytocin, when used in appropriate doses during pregnancy, is able to increase uterine contractions in terms of speed and natural movement force from moderate levels to a long level of prolonged tetanus. Oxytocin causes epithelial muscle cells around the breast follicle bags to facilitate milk secretion. Oxytocin causes the vasodilation of smooth muscle, increasing the circulation through the kidneys, coronary and brain. Blood pressure is usually unchanged, but after intravenous infusion, a large amount of solution, or non -diluted solution, blood pressure may decrease fleeting, fast heart rate and cardiac amount increased due to reflective touch. The initial hypotension is usually accompanied by mild but prolonged hypertension.

In contrast to vascular contractions, oxytocin has a minimum resistance effect; However, water poisoning can occur when using oxytocin with an excess of intravenous fluid without electrolyte and /or at a speed too fast.

pharmacokinetics

by intravenously, effect on the uterus almost appear immediately and decrease within 1 hour. After intramuscular injection, the effect on the uterine muscle tone appears for 3-7 minutes, and lasts 2-3 hours.

Like vascular contractions, oxytocin is distributed in all extracellular fluids. A small amount of oxytocin can be circulated.

The half -life of oxytocin cancellation is 1 - 6 minutes (decreased during overdue pregnancy and breastfeeding period). Most drugs are quickly decomposed in the liver and kidneys. Oxytocin is active by hydrolysis of enzymes, mainly by tissue oxytocinase. Oxytocinase is found in each other and plasma. Only a small amount of oxytocin is eliminated into the urine in a constant form.

Before taking Oxytocin medicine 5 IU/ml indicated in urging, supportive treatment when miscarriage is incomplete (20 blisters x 5 tubes x 1ml)

How to use

Oxytocin 5 IU/mL is used in the infusion, should be done by professional health workers and fully controlled in the hospital. Patients must not arbitrarily take medicine.

Dosage

Dosage must be adjusted according to individual requirements on the basis of mother and fetal response.

The following dosage information is based on general regimens and indications.

Causes or ends:

Intravenous infusion is the only method that is accepted to cause or push. Accurately controlling the speed of infusion is essential. A transmission pump or similar device, regular monitoring of uterine spasms, fetal heart monitoring are essential to cause or finish safely in cases using oxytocin. If the uterus contract is too strong, stop infusing immediately, the uterine stimulation of oxytocin will weaken.

start infusing with a solution that does not contain oxytocin. The physiological solution must be used. This new solution is rotated in an infusion tank to ensure mixing 5 oxytocin/ml mu. Attach this diluted oxytocin solution to an infusion pump or a similar device to accurately control the infusion speed. Increase the dose gradually every 20-40 minutes with the amount of 1-2 mU/minute until the uterus is achieved satisfactory. When the frequency of uterine contractions desires to be established (the uterus can be compared to the natural type of delivery) without signs of pregnancy, and the progressive labor to 4-6 cm, reducing the rate of oxytocin infusion with the same amount. At birth, if using a higher epidemic speed, it must be cautious, rarely more than 8-9 MU/minute. Before the birth may need an infusion at a higher speed, sometimes more than 20 mU/minute. Let the mother breathe oxygen. The treatment doctor must cost the condition of the mother and the fetus.
Intravenous infusion: To control postpartum bleeding, add 10-40 IUUTH oxytocin to 1000 ml of non-hydrated solution and transmission at a speed of 20-40 mU/minute to control uterine tone.
Use intramuscularly: intramuscularly 1 ml (5 IU) oxytocin after export.
Treatment of miscarriage is not completely or inevitable
Add 10 IU Oxytocin to 500 ml of physiological saline, or 5% dextrose solution in physiological saline and infusion at a speed of 20-40 drops/min.
Diagnosis of uterine failure (test oxytocin)
Intravenous infusion, starting 0.5 mU/minute, if needed double every 20 minutes/time until the dose is effective (usually 5-6 mU/minute, up to 20 MU/minute). When there are 3 moderate uterine contractions (for 40-60 seconds) every 10 minutes, stop infusing and monitor manifestations of decreased fetal heart rate or change.
What to do when overdose? Excessive stimulation with strong organs or prolonged (tetanus), or tone of 15-20 mm rest or more between spasms can lead to sudden delivery, uterine rupture, cervical and vaginal injury, postpartum bleeding, reducing uterine blood flow, affecting fetal heart rate, reducing fetal oxygen, hypercaria. Water poisoning combined with seizures caused by the impact of oxytocin's resistance is a serious complication that may be encountered in a large dose (40-50 ml/min).
Treatment of water poisoning includes stopping oxytocin, limiting water absorption, diuretic, for example, using hypertonic solution, adjusting electrolyte imbalance, controlling seizures with barbiturat and special care for coma.
What to do when forgetting a dose?

Side Effects

Notify the doctor with unwanted effects when using the drug.

Unwanted effects for mom:

unwanted effects Blood
reduces blood prothrombin
platelets Supply

Hypotension then hypertension

Postpartum bleeding

Increase uterine muscle tone

Allergic reaction

uterine contractions

tetanus seizures

Unwanted effects

Slow sinus rhythm

tachycardia

Early ventricular

eye disorders bleeding of newborn vascular hemorrhage

Newborn jaundice

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindicated oxytocin injection in any of the following cases:

The ratio between the fetus and the irregular pelvis; The fetus is unfavorable or there are signs that cannot be born without the throne before birth (horizontal throne), that is, in obstetric emergency cases, which are balanced/harmful to the fetus or for the mother to use surgery; In case of pregnancy without labor; taking prolonged drugs in inert uterus or severe poisoning; increase uterine tone; Patients with hypersensitivity to active ingredients or any excipients of the drug; Causing or ending in cases of contraindications to vaginal lines, such as the navel, striker, and striker.

Contraindicated oxytocin for patients with a history of hypersensitivity to the drug.

Do not use oxytocin at the same time with a lot of sugar.

Caution when using

except for exceptions, oxytocin should not be used in the following cases: premature birth, the ratio between the fetus and the pelvis is limited, the previous surgery on the cervix or the uterus includes a baby surgery, the uterus is too tension, many times, or the cervical cervical carcinom. Do not use oxytocin to cause birth before knowing the fetal and pelvic rates. Because of the change in the combination of the factors in the above situation, the identification of "exceptions" belongs to the judgment of the treating doctor. The decision can only make after careful consideration between the potential benefits that oxytocin can bring to the ability to increase tone or tetanus seizures are rare but occur.

oxytocin when used or endings can only be used by intravenously and fully controlled in the hospital. All patients using intravenous oxytocin must be continuously monitored by trained staff with comprehensive knowledge of drugs and capable of recognizing complications. There must always be a doctor who has the ability to quickly handle complications. While using oxytocin, uterine contractions, fetal heart rate and mother's heart rate, the mother's blood pressure must be continuously monitored to prevent complications. If the uterus is too strong, it is necessary to stop using oxytocin immediately; The stimulation of uterine spasm due to oxytocin usually decreases immediately after the drug stops.

When used appropriately, oxytocin stimulates uterine contractions like a conviction in normal labor. Uterine stimulation due to improper use can endanger the mother and fetus. Even when used properly and fully monitored, there is too strong spasms in patients with uterus too sensitive to oxytocin.

Pay attention to the possibility of blood loss and hypoglycemia when using oxytocin.

Died for a mother due to hypertension, underburt bleeding, uterine rupture, and pregnancy due to different causes occurring at the same time with the use of oxytocin injected to cause or ending during the stage I and II of the birth.

oxytocin is essentially anti -cardia, thanks to increased water reabsorption from glomerular filtration. Therefore, it is necessary to consider the possibility of water poisoning, especially when transmitting oxytocin continuously and when patients drink water or use liquid food.

The effect of the drug on driving and operating machinery

The drug does not affect the ability to drive and operate the machine.

Use drugs for women during pregnancy and lactation

Used for pregnant women:

There has been no indication for oxytocin in the first 3 months of pregnancy for any purpose than indicating in terms of scraping and miscarriage. Based on wide experience with this drug and its chemical structure, its pharmacological properties, there will be no abnormal pregnancy when used as prescribed.

Used for breastfeeding women:

oxytocin is found in small amounts in breast milk.

If a patient needs oxytocin to control serious bleeding, do not start breastfeeding until the stopping of oxytocin.

Medicinal interaction

has been seriously hypertension when taking oxytocin after 3-4 hours of spending a vasoconstrictor with an anesthetic anesthetic. Cyclopropan anesthetic can change the effects of oxytocin's cardiovascular effects, causing unexpected results such as hypotension. The slow and abnormal sinus rhythm in the mother has been recorded when using oxytocin simultaneously with cyclopropan anesthetics.

Oxytocin is simultaneously used with Dinoproston can cause hypertension. Oxytocin slows the anesthesia effect of thiopental.

Storage

Store in a dry place, temperature 2-8 ° C.

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