Paincerin 50mg Diacerein Pharmanel Treatment of symptoms of hip degeneration, knee (3 blisters x 10 tablets)

Dosage form Hard capsules
Specifications Box of 3 blisters x 10 tablets
Ingredient Diacerein

Ingredient

Composition information	Content
Diacerein	50mg

Uses

indications

Paincerin is indicated in the following cases:

Symptomatic treatment for patients with hip or knee degeneration, with slow effect.

It is not recommended for diacerein treatment for hip degenerative patients with rapid progression because these patients can respond weakly with Diacerein.

Pharmacokology

ATC: M1AX21

Group of anti -arthritis and rheumatism drugs, non -steroids.

Diacerein is an Anthraquinon derivative that has medium anti -inflammatory effects. The dosage used for anti -inflammatory effects does not cause stomach irritation. The effect of the output drug is slow, often effective when used until the 30th treatment day and lasts until the 45th day. Therefore, Diacerein is often used to support, combined with NSAIDs.

The studies on In vitro shows that the anti -inflammatory effect of diacerein is due to:

Diacerein inhibits the actual and dynamic characteristics of the macronal. Glycosaminoglycan and hyaluronic acid, animal studies also show that diacerein has the effect of reducing cartilage degeneration.

A randomly blind study between the price -using group and the Diacerin group (Echodiah research) conducted more than 507 patients with osteoarthritis have shown that Diacerein significantly slows down cartilage degeneration.

Dynamic pharmacokinetics

absorption: After taking single doses (50 mg), the peak concentration in plasma is achieved after 2.5 hours and the plasma cmax concentration is 3 mg/l. Take Diacerein at a meal that slows down the absorption of drugs into the circulatory system, but increases the total amount of drugs absorbed by 25% (area under the AUC curve).

When using a single dose of 50 - 200 mg of diacerein, pharmacokinetic parameters do not depend on the dose. Dicerein is fully metabolized in the liver, into a Rhein form with a reunited reaction with sulfate before entering the circulatory system.

Distribution: The ratio of binding to high plasma proteins (99%), the active ingredient has high affinity for albumin.

Metabolism: diacerein after taken, deacetyl turned into rhein by a reaction conjugated with sulfate.

Elimination: Thein sale time of thein is about 4.5 hours. 30% of the drug is eliminated through the kidneys, of which 80% of Rhein is excreted in the urine in the form of sulfate and glucoronid, 20% in constant form.

Patients with severe renal failure (creatinine clearance ratio

In the elderly, the ability to absorb the drug is not affected, so there is no need to adjust the dose, but it is necessary to pay attention to the case of poor elimination drugs in the elderly.

Before taking Paincerin 50mg Diacerein Pharmanel Treatment of symptoms of hip degeneration, knee (3 blisters x 10 tablets)

How to use

Drugs used by oral, drugs for adults (over 15 years old).

Dosage

The use of diacerein should be started by a doctor who has experience in treating osteoarthritis.

Because some patients may get out of liquid or diarrhea, Diacerein's recommended starting dose is 50 mg once a day at dinner for the first 2-4 weeks. It may be increased by 50 mg 2 times/day. At that time, you should take medicine with a meal (one in the morning and the other in the evening). The drug must be swallowed intact (do not break the drug) with a glass of water.

Diacerein recommendations for patients over 65 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Treatment: Treatment of symptoms such as water and electrolytes.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Paincerin, you may experience unwanted effects (ADR) such as:

Gastrointestinal disorders

Very common (1/10): diarrhea, abdominal pain. In some cases, serious diarrhea has complications such as dehydration and electrolyte balance disorders.

Melanin infection (Melanosis coli) rarely observed clinically.

Liver system disorders

Less (1/1000 and

Skin and subcutaneous tissue disorders

Common (1/100 and

Other disorders

may encounter dark urine

Data from post -commerce monitoring

Liver system disorders

Cases of acute liver lesions, including liver enzyme hyperplasia and cases of hepatitis related to diacerein have been reported during post -commerce. Most of these cases occur in the first months at the beginning of treatment. Need to closely monitor the signs and symptoms of liver damage in the patient (see the special and cautious warning).

Instructions on how to handle ADR:

Notice to doctors and pharmacists when encountering any unwanted effects of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Paincerin drugs contraindicated in the following cases:

Patients with liver diseases or a history of liver disease. Self.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

diarrhea:

Taking Diacerein regularly can cause urination (see unwanted effects), thereby leading to dehydration and hypokalemia. Patients should stop using diacerein when diarrhea and exchange with the doctor for treatment of alternative treatments.

Be cautious when using diacerein for patients using diuretics due to increased risk of dehydration and hypokalemia. Particularly cautious to prevent blood potassium when patients use simultaneously cardiac (Digitoxin, Digoxin).

Avoid simultaneous use of diacerein with laxatives.

Special and cautious warning: Hepatotoxicity

Increased serum liver enzyme level and acute liver damage symptoms were recorded during the circulation of diacerein on the mayor (see the unwanted effect).

Before starting treatment with diacerein, the patient should be asked for attached and history diseases, especially liver diseases and screening the main causes of progressive liver disease. If diagnosed with liver diseases is identified, contraindicated using diacerein (see the contraindications section).

Need to closely monitor the signs of liver damage and caution when using diacerein simultaneously with drugs that can cause liver damage. Recommend patients to reduce alcohol while being treated with diacerein.

Stop taking the drug if the liver enzyme is detected or suspected to show signs or symptoms of liver damage. Advise patients on the signs and symptoms of liver toxicity and ask the patient to immediately contact the treating doctor in case of detecting signs of liver damage.

Other warning cases:

Not used for children under 15 years old.

The effect of the drug on driving and operating machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Data research on experimental animals shows that when using high doses of Diacerein can delay the process of cartilage reinforcement in the fetus. There are currently no reliable clinical data to assess the effect of diacerein on pregnant women, so it should not be used for pregnant women.

breastfeeding women:

Anthroquinon's derivatives are known to be able to excrete in breast milk. Therefore, Diacerein should not be used for breastfeeding women.

Drug interaction

using diacerein can cause diarrhea and hypotension. Be careful when used simultaneously with diuretics (diuretics and thiazids) or with purple glycosides (digitoxin, digoxin) due to increased risk of arrhythmia (see caution).

Should avoid simultaneous use with salt, oxid or aluminum hydroxide, calcium and magnesi hydroxid because they reduce the absorption of diacerein. These substances can be used at another time (more than 2 hours) after drinking paint.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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