Painkiller TK3 300mg Hadiphar helps relieve pain and fever (10 blisters x 10 tablets)

Dosage form Hard capsules
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen, phenylephrine, caffeine
Indication Rhinitis, sinusitis, fever, cold, headache, stuffy nose
Contraindication Prostate hypertrophy, bronchial asthma attacks, diabetes (diabetes), anemia, heart failure, high blood pressure, angina, hyperthyroidism

Ingredient

Composition information	Content
Acetaminophen	300mg
Phenylephrine	5mg
Caffeine	25mg

Uses

Indications

Painkillers TK3 are indicated in the following cases:

Treatment of symptoms in the following cases: fever, headache, migraine, toothache, sore throat, after tooth extraction, dysmenorrhea, musculoskelosis, pain caused by arthritis, nerve pain, fever in inflammation.

pharmacokinetics

No report.

Before taking Painkiller TK3 300mg Hadiphar helps relieve pain and fever (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults (including the elderly) and children aged 12 and older

Should use 2 capsules at a time. Minimum dose distance: 4 hours. Maximum daily dose: 12 tablets in 24 hours.

Maximum time of using a doctor without advice from a doctor: 7 days.

Children under 12 years old

Do not recommend this medication.

Do not overdose indicated. Do not use with other drugs containing paracetamol, anti -congested drugs, other anti -flu drugs.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression

Paracetamol poisoning can be used by a single dose, or due to a large dose of paracetamol (for example, 7.5 - 10g a day, for 1-2 days), or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poisonous dose of the drug. Methemoglobin - blood, leading to purple blue, mucous membranes and nails is a sign of acute poisoning P - Aminophenol, a small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated, and delirium. Next can be inhibiting the central nervous system, stunned, lower body heat, tired, fast breathing - shallow, fast circuit - weak - irregular, low blood pressure, circulatory failure. Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of plasma bilirubin can also increase. In addition, when the liver lesions spread, the long prothrombin time. It is possible that 10% of patients with untreated poisoning have serious liver damage, out of which 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. The liver biopsy detects the central necrosis of the lobe except the area around the door vein. In cases of non -death, liver lesions recover after weeks or months.

Phenylephrin HCl: Overdose of hypertension, headache, convulsions, cerebral hemorrhage, chest drum, extra -systolic, paresthales, slow heart rate often occur early.

Handling

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver.

n-acetylcysteine works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N - Acetylcystein with the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N - Acetylcystein includes skin rash (including urticaria, no need to stop the drug), nausea, vomiting, diarrhea, and anaphylactic reaction.

If there is no N - acetylcystein, methionine can be used (see specialized methionine). Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

Hypertension can be overcome by taking α-adrenergic blockers like phentolanim 5-10mg intravenously. Pay attention to symptomatic treatment and support for health care.

What to do when forgetting 1 dose?

Side Effects

When using TK3 analgesics, you may experience unwanted effects (ADR).

paracetamol

Very rare (

Blood disorders and lymphatic systems: thrombocytopenia.

The immune system disorder: Hypersensitivity reaction. Skin allergic reactions such as erythematosus, angiography, Stevens - Johnson syndrome.

Respiratory, chest and medical disorders: bronchospasm in patients sensitive to aspirin and other NSAIDs.

Liver disorders: Liver abnormalities.

caffein

Not determining the frequency

Central nervous system: restlessness, dizziness. When using the dose of Paracetamol recommendations - caffeine along with a caffeine diet, may experience side effects due to caffeine overdose such as insomnia, awake, anxiety, irritability, headache, digestive disorders, suspense.

phenylephrin

Mental disorders: restlessness.

Disorders on the nervous system: headache, dizziness, insomnia.

Disorders on the heart: hypertension.

Disorders on the gastrointestinal tract: nausea, vomiting.

Eye disorders: Dilate pupils, acute angle glaucoma, often occurs in patients with a history of closed angle Glaucoma.

Disorders on the heart: tachycardia, nervousness.

Skin and subcutaneous disorders: Allergic reactions (such as rash, urticaria, atopic dermatitis).

Renal and urinary disorders: Urinary retention. Often occurs in patients with congested sub -tracts such as patients with pre -hypertrophy.

Instructions on how to handle ADR

Consult your doctor, pharmacist if you experience unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Analgesics TK3 Contraindicated in the following cases:

Do not use drugs for patients with a history of hypersensitivity to paracetamol, phenylephrin HCl, caffeine or any ingredient of the drug.

Simultaneous use of sympathetic nerve stimulants.

adrenal glands.

GloCom closed angle.

kidney failure or severe kidney failure, high blood pressure, hyperthyroidism, diabetes and heart disease.

Patients with three -ring antidepressants, beta blockers and those who are using either or have been used within two weeks of Monoamine Oxidase inhibitors.

Be cautious when using

paracetamol is relatively non -toxic to the dose of treatment and when used under the guidance of a physician. However, overdose of paracetamol is the main cause of acute liver failure. Using many preparations containing paracetamol (acetaminophen) and can lead to harmful consequences (such as paracetamol overdose).

Serious, fatal skin reactions include Stevens-Johnson syndrome, poisoned epidermal necrosis (Spanish), all-body pustules syndrome (AGEP: Acute Generalized Exanthematous), Lyell syndrome is rare but has occurred with paracetamol, often does not depend on the effects of other drugs. While other painkillers and antipyretic (such as NSAIDs) can cause similar reactions. Patients need to stop using paracetamol and see a physician as soon as they see rash or other manifestations in the skin or sensitive reactions during treatment. Patients with a history of such reactions should not be used in preparations containing paracetamol.

Sometimes there are skin reactions including rugged rash and urticaria, other sensitive reactions including laryngeal edema, angioedema, and anaphylactic reactions that rarely occur. Thrombocytopenia, leukemia. And reducing all bloody platelets occurred with the use of p-aminnophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Be cautious when using paracetamol for people with liver failure, kidney failure, alcoholic, chronic malnutrition or dehydration. Avoid high doses, prolonged use. Paracetamol must be used in patients with anemia before, because purple blue may not manifest clearly, although high concentrations at a dangerous level of methemoglobin in the blood. Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

Be careful when taking medication for the elderly, people with hyperthyroidism, slow heartbeat, partial heart block, severe arteriosclerosis heart disease, type 1 diabetes. Avoid using too much caffeine while taking this medication.

The ability to drive and operate machinery

Patients with dizziness due to drug use, should not drive and operate machinery.

Pregnancy

Do not recommend this medication.

Paracetamol: Studies have not yet determined any risks for pregnancy or embryo development.

caffeine: do not recommend this medication.

phenylephrin: no data.

Breastfeeding period

If there is no doctor's prescription, you should not use this medication during breastfeeding.

Paracetamol: Human studies at the recommended doses do not identify any risks for nursing or breastfed women.

Cafein in breast milk may have a stimulating effect for breastfeeding but have not observed significant toxicity.

phenylephrin: can be excreted in breast milk.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion. It is necessary to pay attention to the likelihood of serious antipyretics in patients using simultaneously phenothiazine and cooling therapy. Drinking too much and long alcohol can increase the risk of Paracetamol's liver toxicity.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions. However, patients must restrict self -use of paracetamol while taking anti -convulsions or isoniazid.

Phentolamine and α-adrenergic blockers: The hypertension effect of phenylephrin will decrease, if before that, it has been used α-adrenergic blockers like phentolamine mesylate. Phentolamine can be used to treat hypertension due to phenylephrin overdose.

propranolol and β -adrenergic blockers: The heart stimulation effect of phenylephrin hydrochloride will be inhibited by using the β -adrenergic blockers like propranolol. Propranolol can be used to treat arrhythmia due to phenylephrin.

Aids (oxytocin): When combined with phenylephrin hydrochloride (a drug causing hypertension) with a supportive drug, hypertension effect will increase.

Phenylephrin hydrochloride is not used in combination with epinephrin or other sympathetic drugs, as tachycardia and perhance may occur.

Mesmerizing: combining phenylephrin hydrochloride with anesthetics is hydrocarbon halogenization (eg cyclopropan) increases heart irritation and can cause arrhythmia.

Do not use oral phenylephrin oral phenyle in combination with Mao inhibitors. The three -round antidepressants (such as imipramin) or guanethidin also increases the effect of hypertension of phenylephrin. Atropin sulfate and other eyelash paralysis when combined with phenylephrin will block the slow effect of reflective heart rate, increasing the effect of hypertension and pupils of phenylephrin. Alcaloid mushrooms with potential format (such as Ergonovin Maleat) when combined with phenylephrin will increase blood pressure very strongly.

Digitalis in combination with phenylephrin increases the sensitivity of the heart muscle due to phenylephrin.

Furosemid or other diuretics reduces hypertension due to phenylephrin.

Pilocarpin is a pupil, which is antagonistic with the dong -expanding effect of phenylephrin. After using phenylephrin to relax the pupil to complete the eye diagnosis, Pilocarpin can be used to recover faster.

With Guanethidin: using phenylephrin for patients for a long time to take guanethidin, the dong -expanding response of phenylephrin increases and the blood pressure has increased very strongly.

With Levodopa: The omnel of the pupils of phenylephrin is greatly reduced in patients using Levodopa.

Not used with bromocriptin because of vasoconstrictor and hypertension.

Should avoid drinking too much caffeine (for example, coffee, tea and some boxes) while using this product.

Need to consult a doctor and pharmacist before taking an analgesic capsules TK3 with the following drugs:

Monoaminase inhibitors oxidase (including moclobemide): interactions that cause hypertension occur between nerve stimulating amines such as phenylephrin and monoamine. Oxidase inhibitors (see contraindications).

Amines stimulate sympathetic nerve: simultaneous use of phenylephrin with other sympathetic nerve stimuli can increase the risk of cardiovascular side effects.

Beta blockers and other anti -hypertension drugs (including Debrisoquin, Guanethidin, Reserpin, Methyldopa): Phenylephrin can reduce the effectiveness of beta inhibitors and anti -blood pressure drugs. The risk of high blood pressure and other cardiovascular side effects may increase.

Triple -level antidepressants (eg Amitriptylin): may increase the risk of cardiovascular side effects.

Digoxin and cardiac glycosides: Concomitance use of phenylephrin with digoxin or cardiac glycoside can cause irregular or heartbeat or heart attack.

Alcaloid barley: (ergotamine and methylsergid) increases the risk of ergotin poisoning.

Warfarin and other coumarin: Warfarin's anticoagulant effect and other cooumarin can be enhanced by using Paracetamol regularly daily lasting with high risk of bleeding, regular doses that are not significantly effective.

Storage

Store in a cool dry place, temperatures below 30 ° C, avoid light.

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