Pamlonor 5mg Polfa tablets treat hypertension (9 blisters x 10 tablets)

Dosage form Box of 9 blisters x 10 tablets
Specifications Amlodipine

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

Indications

Pamlonor drugs are indicated in the following cases:

Treatment of hypertension, use alone or combine other medications for hypertension. A calcium antagonist belongs to the dihydropyridine group. The calcium inhibitor passes through the membrane into the myocardial and smooth muscle cells by preventing the slow calcium channels of the cell membrane. Thanks to the effect of the drug, the smooth muscle tone of the blood vessels decreases, thereby reducing the peripheral resistance, leading to lowering blood pressure.

Amlodipin Anti -angina is mainly due to the relaxing peripheral artery and reducing cardiac load. The consumption of energy and oxygen needs of the heart muscle decreases because the drug does not cause reflexes of tachycardia. Amlodipine relaxes coronary artery (arteries and urine) in normal and anemic region leading to increased oxygen supply to the heart muscle.

pharmacokinetic

absorption

Amlodipin's bioavailability when drinking about 60 - 80% and not affected by food. Selling time is from 30 - 40 hours. Stable plasma concentrations reach 7-8 days after taking the drug once a day.

Distribution

The distribution volume is approximately 21 l/kg body weight and drugs linked to protein - high plasma (over 98%).

Metabolism and elimination

Maximum metabolic drugs are mainly through the liver. The metabolites are inactive and excreted through the urine. In people with liver failure, the dose should be reduced or prolonged the dosage.

Before taking Pamlonor 5mg Polfa tablets treat hypertension (9 blisters x 10 tablets)

How to use

Oral drugs.

No need to abstain from food and drink when using the drug.

Dosage

High blood pressure

The initial recommended dose is 5mg a day. In some cases (light weight, elderly, liver function impairment, using other lowering blood pressure drugs) The starting dose is 2.5mg a day. The maximum dose is 10mg in 1 day.

Stable angina

The recommended dose is 5 - 10mg in 1 day. Severe patients use 10 mg/day. Patients with impaired liver function recommended starting from 5mg/day.

This drug does not require a dose change for patients with renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? In some cases, gastric lavage may be helpful. Existing data have suggested that overdose in large amounts can lead to excessive peripheral vessels with obvious systemic hypotension and prolonged potential. Hypotension effects on clinical status due to amlodipin overdose need positive cardiovascular support measures including regular heart and respiratory function test, limb high, and monitoring the volume of circulatory fluid and urine intake. Without contraindications, a vasoconstrator can help recover blood vessels and blood pressure. Calcium gluconate intravenous can be restored to restore the effect of calcium channel blockers. Because amlodipine is closely linked to protein, the fertilizer has almost no results.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pamlonor, you may experience unwanted effects (ADR).

Common

Beat the chest, dizziness, headache, drowsiness, nausea, abdominal pain, face, edema.

arrhythmia includes ventricular tachycardia and atrial fibrillation, slow heartbeat, chest pain, fainting, fast heartbeat, dizziness, hypotension, peripheral ischemia, leukopenia, hemorrhage, platelet reduction; Reducing sensory, peripheral neuralgia.

constipation, indigestion, diarrhea, flatulence, vomiting. Meet

Heart failure, heart disorder, extra -syllable, loss of movement air conditioning, taste disorders, sense of smell, migraine, forgetting, indifference, irritation, appetite, daily -life disorders, traumatic conjunctivitis. Urticaria, dry skin, dermatitis, cold and moist skin.

Very rare

Increase liver, jaundice, bile stasis, big breasts in men.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pamlonor drugs are contraindicated in the following cases:

Hypersensitivity to amlodipine, derivatives of dihydropyridine or any ingredients of the drug.

Sudden hypotension. shock (including cardiac shock).

Conclusion of the left ventricular ventricular (eg aortic stenosis is severe).

Hemorrhagic heart failure when hemodynamics are not stable after acute myocardial infarction.

Children.

Be cautious when using

Do not use amlodipine in case of cardiac shock, clinical symptoms characterized by aortic stenosis, unstable angina (except in the case of prinzmetal angina).

In some cases, especially patients with artery stenosis using antagonistic drugs or increased dose previously can lead to decreased angina or acute myocardial infarction.

kidney failure

amlodipin converts into non -activity metabolites with 10% excretion through unchanged urine. Amlodipine plasma changes are not related to the level of renal failure. Amlodipin can be used for these patients in normal doses. Amlodipin cannot be appraised.

Patients with liver failure

Amlodipine's exhaust time is prolonged in patients with liver failure and has not yet identified the recommended dose. Therefore, caution should be used in these patients.

The ability to drive and operate machinery

There is no document on the effect of the drug on driving and operating machinery. However, it is necessary to be cautious because like other drugs for hypertension, the drug can cause dizziness and dizziness.

Pregnancy

The safety of amlodipine during pregnancy or breastfeeding in humans has not been determined. Amlodipin does not show toxicity in animal reproductive research in addition to slowing labor and prolonging the birth of mice with a dose of 50 times higher dose recommended for humans. Therefore, only use during pregnancy when there is no other replacement drugs safer and when the disease itself has a higher risk for the mother and the fetus.

Breastfeeding period

There is no information on Amlodipin's accumulation in breast milk. Therefore, it is recommended to stop breastfeeding when using amlodipine.

Medicinal interaction

When using simultaneously amlodipine and sildenafil each drug has a decrease in blood pressure independently.

Amlodipin has been safely used with thiazide diuretics, Apha and beta inhibitors, enzyme inhibitors, long -lasting nitrate, nitroglycerin under the tongue, non -steroid anti -inflammatory drugs, antibiotics and oral hematurian drugs

Studies have shown that using amlodipine with digoxin does not change the concentration of Digoxin in serum or clearing digoxin in the kidney of a healthy volunteer, and when used simultaneously with cimetidine does not change the pharmacokinetics of amlodipine.

In vitro research data with plasma has shown that amlodipine does not work on the bond with the protein of testing reactions (digoxin, phenytoin, warfarin or indomethacin).

In men who volunteered healthy, simultaneously using Amlodipin does not significantly change the effects of warfarin on prothrombin time.

Cyclosporin pharmacokinetic studies show that amlodipine does not significantly change the pharmacokinetics of cyclosporin.

Storage

Store at temperatures below 30 ° C, in closed packaging, avoid light.

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