Panactol 500mg khapharco tablets relieve pain, reduce fever, treat headache, toothache (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

Panactol drugs are indicated in the following cases:

Paracetamol is a mild analgesic and antipyretic, used for treatment in most pain and fever such as headache including migraine, headache, toothache, back pain, muscle and joint pain, dysmenorrhea, sore throat and fever, pain and pain in the flu, colds.

Pharmacy

paracetamol: painkillers, fever. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug acts on the hypothalamus (hypothalamus) that cools down, increases heat due to vasodilation and increases peripheral blood flow.

pharmacokinetics

paracetamol is quickly absorbed and almost completely through the digestive tract, the peak concentration in plasma is within 30 - 60 'after drinking with the dose of treatment.

Paracetamol is distributed quickly and evenly in most body tissues, about 25% of the blood paracetamol combined with plasma proteins.

The half -life of paracetamol excretion is 1.25 -3 hours, which can last for toxic doses or in patients with liver damage.

After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); It also detects a small amount of hydroxy metabolites - chemicals and reducing acety. Young children are less likely to be more in line with the drug than adults.

Paracetamol is n-hydroxylation by cytochrom P450 to create n-acetylbenzoquinonimin, an intermediary with high reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus is dedicated. However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In this situation, its reaction to the sulfhydryl group of liver protein increases, which can lead to liver necrosis.

Before taking Panactol 500mg khapharco tablets relieve pain, reduce fever, treat headache, toothache (10 blisters x 10 tablets)

How to use

Panactol drugs are taken orally.

Dosage

Adults, elderly and children over 16 years old: 1 - 2 tablets every 4 hours as required.

Children from 10 - 15 years old: 1 tablet every 4 hours if needed as required.

Children under 10 years of age: This form of preparation is not suitable for children under 10 years old.

Children should not take paracetamol for more than 3 days without consulting the doctor.

Do not repeat the dose less than 4 hours and a maximum of no more than 4 doses in 24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Overdose of 10g (150 mg/kg of weight in children can cause liver cell cancellation, which can lead to absolutely non -recovery necrosis, with expression of liver function, brain disease can lead to coma and death. Transaminase in the liver increases, bilirubin increases, prothrombin decreases.

Hospital treatment in the hospital: Bowel washing and drinking activated carbon. Using N-acetylcystein, paracetamol antidote, intravenous or taken if possible before the 10th hour.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Panactol, you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs. In a few specific cases, paracetamol has caused neutropenia, thrombocytopenia and all bloody reduction.

Uncommon, 1/1000

Skin: Ban.

Hematology: Dehydration, anemia.

Other: Hypersensitivity reaction.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Panactol drugs are contraindicated in the following cases:

Hypersensitivity to paracetamol.

Be cautious when used

use high -dose high -dose paracetamol that can slightly increase the anticoagulant effect of COMAARIN and Indandion derivatives.

Out of too much and long -term alcohol can increase the risk of paracetamoi toxicity to the liver.

Be cautious when coordinating with anti -convulsions (carbamazepin, phenytoin, barbiturat), isoniazid: Increased risk of paracetamol toxic to the liver.

The ability to drive and operate machinery

There is no evidence of the effects of drug ability to drive, operate machinery.

Pregnancy

only used when really necessary.

Breastfeeding period

There is no unwanted effect in breastfeeding, so they can be used for breastfeeding women.

Medicinal interaction

using high -dose high -dose paracetamols can slightly increase the anticoagulant effect of COMAARIN and Indandion derivatives.

Out of alcohol too much and long may increase the risk of paracetamol toxicity to the liver.

Be cautious when coordinating with anti -convulsions (carbamazepin, phenytoin, barbiturat), isoniazid: increasing the risk of paracetamol increases toxicity to the liver.

Storage

under 30 ° C, in a dry place, avoiding light.

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Disclaimer

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