Panactol 650mg khapharco tablets relieve pain, reduce fever, do not cause drowsiness (1000 tablets)

Dosage form Bottle 1000 tablets
Specifications Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	650mg

Uses

indications

Panactol 650 drug is indicated in the following cases:

Treatment of symptoms of pain, mild to medium fever in the following cases: colds, flu, headache, muscular pain, sprain, joint pain, back pain, toothache, dysmenorrhea, trauma, nerve pain, ear pain, sore throat, dental surgery, tooth extraction, tonsillectomy.

Pharmacokinus

Acetaminophen is an effective analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

Dynamic pharmacokinetics

Absorption: Acetaminophen when taken will be absorbed quickly and completely. The peak concentration of plasma is about 10-60 minutes after drinking.

Distribution: fast and uniform in most body tissues, about 25% acetaminophen in the blood combined with plasma protein.

Metabolism: Acetaminophen is metabolized mainly in the liver in two main paths in the liver, which is associated with glucuronic acid and associated with sulfuric acid, combined with sulfuric acid quickly saturated when using the dose more but still within the treatment dose. The saturation of the glucoronid process appears only when the dose is higher, toxic to the liver. A small part (less than 4%) is metabolized by Cytochrome P450 forming a high reaction mediator (N-acetyl Benzoquinoneimin), under normal use, this intermediate will be detoxified by glutathion reduction and is eliminated in urine after conjugated with cysteine and mercapturic acid. However, when poisoning with high doses of acetaminophen, the amount of toxic metabolites increased.

Elimination: Acetaminophen metabolites are mainly eliminated in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate complex (about 30%). Under 5% is eliminated in constant form. Selling time for plasma is about 2 hours.

Before taking Panactol 650mg khapharco tablets relieve pain, reduce fever, do not cause drowsiness (1000 tablets)

How to use

Take oral use. Should drink during or after meals.

Dosage

Adults and children over 12 years: 1 capsule/time. No more than 6 tablets/day. Distance 2 times 4 - 6 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical expert

What to do when overdose? Overdose of 10g (150 mg/kg of weight in children) can cancel liver cells, which can lead to absolutely non -recovery necrosis, with manifestation of liver function, brain disease can lead to coma and death. Transaminase in the liver increases, increased bilirubin, decreasing prothrombin.

Emergency treatment: In the hospital:

Bowel washing and activated carbon drinks. Also can use activated carbon and/or salt bleach, they have the ability to reduce paracetamol absorption.

help breathe. However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Panactol 650, you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to acetaminophen and related drugs. In a few individual cases, acetaminophen has caused neutropenia, thrombocytopenia and hypoglycemia.

Less:

DA: DA

Digestive: Stomach irritation

Instructions on how to handle ADR: When the side effects of the drug are encountered, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Panactol 650 drug contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when used

Be careful in patients with anemia before, impaired liver and kidney function. Overdose or long -term treatment can cause liver necrosis, kidney failure.

Drinking plenty of alcohol can cause toxicity to the liver of acetaminophen, should avoid or limit drinking.

For drugs containing acetaminophen: Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

The ability to drive and operate machinery

The drug does not cause dizziness, drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

only use drugs for pregnant women when really necessary.

breastfeeding period

must be very cautious when taking medicine for nursing women.

Drug interaction

long -term oral acetaminophen -doses increases the anticoagulant effect of COUMARIN and derivatives.

Anti -seizure drugs (phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxicity of acetaminophen.

drinking and long -term alcohol increases acetaminophen's liver toxicity.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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