Panactol extra khapharco tablets reduce fever, analgesic (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Caffeine, paracetamol

Ingredient

Thành phần cho 1 viên

Composition information	Content
Caffeine	65mg
Paracetamol	500mg

Uses

indications

Panactol extra is indicated in the following cases:

Analysis: headache, migraine, dysmenorrhea, sore throat, muscle pain, bone, fever and pain after vaccination, after tooth extraction/ Dental surgery, toothache, osteoarthritis.

Fast antipyretic.

Pharmacokinus

Paracetamol is an effective analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

caffeine has a slight stimulating effect on the central nervous system, supports pain relief and makes it easy for muscle activity.

pharmacokinetics

paracetamol

Absorption:

Paracetamol, when taken, will be absorbed quickly and completely.

fast and uniform in most body tissues, about 25% of the blood paracetamol in combination with plasma proteins.

Paracetamol is metabolized mainly in the liver in two main roads, which are associated with glucuronic acid and associated with sulfuric acid. A small part (less than 4%) is metabolized by Cytochrome P450 forming a high reaction intermediate (N-acetyl Benzoquinoneimin), under normal usage conditions, this intermediate will be detoxified by glutathion reduction and is eliminated in urine after intercourse with cysteine and mercapturic acid. This toxic chemistry increases.

Elimination:

Paracetamol metabolites are mainly excreted in urine, in adults, about 90% of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and Sulfate Intercent (about 30%). hour.

absorption:

fast absorption after drinking.

Distribution:

Wide in the body.

is almost completely in the liver through oxidation and acetylation and is excreted in the form of 1-methyluric acid, 1-methylxanthin, 7-methylxanthin, 1.7-dimethylxanthin, 5-acetyl amino-6-formylamino-3-methyluracil and in the form of non-metabolic 1%. Subtract:

Cafe waste time for 3-7 hours in adults and 3-4 hours in infants.

Before taking Panactol extra khapharco tablets reduce fever, analgesic (10 blisters x 10 tablets)

How to use

Panactol extra pills long tablets orally.

Dosage

Adults and children over 12 years: 1 capsule/time. No more than 6 tablets/day. Distance 2 times 4 - 6 hours.

Children under 12 years: consult a doctor.

Should drink during or after meals.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Clinical symptoms:

Nausea, vomiting, abdominal pain, purple blue, mucous membranes, usually occur within 2-3 hours after taking the poisonous dose of the drug, appearing in the first 24 hours. Overdose of 10g (150 mg/kg of weight in children) can cancel liver cells, which can lead to absolutely non -recovery necrosis, with manifestation of liver function, brain disease can lead to coma and death.

Bowel washing and drinking activated carbon.

Use N-acetylcystein, paracetamol detoxification, intravenously or drink if possible before the 10th hour.

Help patients breathe.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using Panactol Extra that you may encounter.

Less:

DA: Ban Da.

Gastrointestinal: stomach irritation.

Hematology: Dehydration, anemia.

Kidney: Kidney disease, kidney toxicity when abusing for a long time.

Rare: Hypersensitivity reaction.

Instructions on how to handle ADR: When the side effects of the drug are encountered, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Too hypersensitivity to any ingredients of the drug.

Glucose-6-phosphate dehydrogenase deficiency.

Progressive hepatitis, people with severe liver failure.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Be careful in patients with anemia before, impaired liver and kidney function. Overdose or long -term treatment can cause liver necrosis, kidney failure.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

Patients are using beta-adrenergic receptor inhibitors.

For Paracetamol-containing drugs: Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

Use cautious for people with angina or heart muscle damage, stomach ulcer, diabetes, hypertension, glaucoma.

Need to monitor caffeine concentration in the serum of people with heart failure, viral cirrhosis, liver failure in the elderly.

To be out of reach of children.

The ability to drive and operate machinery

Persons who often drive or operate machinery should use Panactol Extra?

The drug does not cause dizziness, drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

Women during pregnancy should use Panactol Extra?

Only use drugs for pregnant women when really necessary.

Breastfeeding period

Women who breastfeeding should use Panactol Extra?

Must be very cautious when taking medicine for breastfeeding women.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

with paracetamol

Paracetamol long -dose long -dose drinks slightly increase the anticoagulant effect of COMAARIN and conducting indandion.

Anti -seizures (phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxic of paracetamol.

Drinking a lot of alcohol and long days increases the toxicity on the liver of paracetamol.

with caffeine

caffeine increases lithium elimination and reduces the treatment effect of this drug.

When used simultaneously caffeine with epherin and other sympathetic nerve effects make the patient more easily disordered.

When used simultaneously caffeine with cimetidin, high doses of allurinol, oral contraceptives, propranolol, ciprofloxacin, erythromycin, fluvoxamin, troleandomycin reducing caffeine clearance in the liver.

Storage

Leave a cool dry place, avoid light, temperature below 30⁰C.

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