Panactol hard capsules 500mg khapharco analgesic, fever (200 tablets)

Dosage form Tablet
Specifications Bottle of 200 tablets
Ingredient Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

Panactol 500mg drug indicated to reduce the symptoms:

Antipator, mild to medium analgesic such as: Analgesic in headaches, migraines, toothache, sore throat, dysmenorrhea, rheumatoid pain, muscle aches, flu. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

Paracetamol does not have the effect of inflammation treatment.

With the dose of treatment, paracetamol metabolizes mainly through a suifat and glucuronid complex reaction. A small amount usually converts into a toxic metabolite, N-acetyl-P-Benzoquinonimin (NAPQI).

Napqi is detoxified by glutathion and eliminated into urine and/ or bile. When metabolites are not connected to glutathion, it will be toxic to liver cells and necrotic cells.

Paracetamol is often safe when used for treatment, because the amount of Napqi is formed relatively low and glutathion formed in liver cells that are sufficiently associated with NAPQI. However, when overdose or sometimes with the common doses used in some sensitive people (such as malnutrition, drug interaction, alcoholism, genetics), Napqi concentration can be accumulated toxic in the liver.

pharmacokinetics

Absorption:

Paracetamol when taken will be absorbed quickly and completely. The peak concentration of plasma is about 10-60 minutes after drinking.

Distribution:

fast and uniform in most body tissues, about 25% paracetamol in the blood combined with plasma proteins.

Metabolism:

Paracetamol is metabolized mainly in the liver in two main paths in the liver: associated with glucuronic acid and associated with sulfuric acid.

Integrated with sulfuric acid quickly saturated when taking a higher dosage but still within the scope of treatment. The saturation of the glucoronid process appears only when the dose is higher, toxic to the liver.

A small part (less than 4%) is trips by Cytochrom P450 to form a high reaction intermediate (N-acetyl Benzoquinoneimin), under normal usage conditions, this intermediate will be detoxified by glutathion reduction and eliminated in urine after connected with cystein and mercapturic acid. However, when poisoning with high doses of paracetamol, the amount of metabolites has this toxicity increases.

Era:

Paracetamol metabolites are mainly eliminated in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate complex (about 30%).

less than 5% are eliminated in a constant form. Selling time for plasma is about 2 hours.

Before taking Panactol hard capsules 500mg khapharco analgesic, fever (200 tablets)

How to use

Panactol 500mg drug used orally. Should drink during or after meals.

Dosage

Adults and children over 12 years: 1 capsule/time. No more than 6 tablets/day. Distance 2 times 4-6 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Clinical symptoms:

Nausea, vomiting, abdominal pain, purple blue, mucous membranes, usually occur within 2-3 hours after taking the poison of the drug, appearing in the first 24 hours.

Overdose of 10g (150 mg/kg of weight in children) can cause liver cell cancellation, which can lead to absolutely non -recovery necrosis, with manifestation of liver function, brain disease can lead to coma and death.

Transaminase in the liver increases, increased bilirubin, decreasing prothrombin.

Emergency treatment at the hospital:

Bowel washing and drinking activated carbon.

Use N-acetylcystein, paracetamol detoxification, intravenously or drink if possible before the 10th hour.

without n-acetylcystein, methionine may be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

Help breathing.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects when using Panactol 500mg that you may encounter.

Skin rash and other allergic reactions occur. Usually the erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions.

Patients with hypersensitivity to rare salicylate sensitive to acetaminophen and related drugs. In a few individual cases, acetaminophen has caused neutropenia, thrombocytopenia and hypoglycemia.

Less:

DA: Ban Da.

Digestive: stomach irritation.

Hematology: Dehydration, anemia.

kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare: Hypersensitivity reaction.

Instructions on how to handle ADR: When the side effects of the drug are encountered, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Panactol medicine 500mg contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when used

Be careful in patients with anemia before, impaired liver and kidney function. Overdose or long -term treatment can cause liver necrosis, kidney failure.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

For Paracetamol-containing drugs: Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

The ability to drive and operate machinery

The drug does not cause dizziness, drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

only use drugs for pregnant women when really necessary.

breastfeeding period

must be very cautious when taking medicine for nursing women.

Drug interaction

Long -term oral high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

It is necessary to pay attention to the possibility of serious heat lowering the patient and phenothiazine and cooling (such as paracetamol).

Anti -seizure drugs (Phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxic of paracetamol.

Probenecid may reduce paracetamol elimination and increase the half -life of plasma of paracetamol.

Isoniazid and anti -tuberculosis drugs increase the toxicity of paracetamol for the liver.

Metoclopramid, domperidon increases the absorption speed of paracetamol, cholestyramin reduces the absorption rate of paracetamol

Out and long -term drinking increases the toxicity on the liver of paracetamol.

Storage

Leave a cool dry place, avoid light, temperature below 30⁰C.

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