Panadol 500mg effervescent tablets are lemon flavor - pain relief, antipyretic, no stomach harm (5 blisters x 4 tablets)

Dosage form Box of 5 blisters x 4 tablets
Specifications Paracetamol

Ingredient

Composition informationContent
Paracetamol500mg

Uses

indicated:

Panadol effervescent pellets containing paracetamol is an antipyretic and pain relief.

Treatment of mild to medium pain includes: headache, migraine, muscle aches, dysmenorrhea, sore throat, muscular pain, fever and pain after vaccination, pain after tooth extraction or after dental procedures, toothache, osteoarthritis pain.

A reduction of fever.

Pharmacokinus

paracetamol is an analgesic and antipyretic. Unlike traditional nonsteroidal anti -inflammatory drugs (NSAID), paracetamol does not inhibit platelet function at the dose of treatment.

Mechanism of action: The exact mechanism of paracetamol analgesic and antipyretic effects has not been determined. The mechanism of action can be related to the effects at the central and peripheral.

Dynamic pharmacokinetics

Absorption: Paracetamol when taken or taken will be absorbed quickly and completely. The peak concentration of plasma is about 10-60 minutes after drinking.

Distribution:

paracetamol is quickly distributed into most tissues.

In adults, the distribution of Paracetamol is about 1-2 liters/kg and in children between 0.7-1.0 liters/kg.

Paracetamol does not strongly connect with plasma proteins.

Metabolism:

  • Paracetamol is metabolized mainly in the liver in two main paths in the liver: associated with glucuronic acid and associated with sulfuric acid; Combined with sulfuric acid quickly saturated when using higher doses but still within the scope of treatment. Usually, this intermediate will be detoxified by glutathion removal and is eliminated in the urine after connecting with cysteine ​​and mercapturic acid. However, when poisoning with high doses of Paracetamol, this amount of toxic metabolites increased.
  • Paracetamol metabolites are mainly excreted in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate conjugate (about 30%). Under 5% is eliminated in the form of constant.

    • Before taking Panadol 500mg effervescent tablets are lemon flavor - pain relief, antipyretic, no stomach harm (5 blisters x 4 tablets)

    How to use

    Take oral use.

    Dosage

    Adults (including the elderly), children aged 12 and older: Dissolve 1-2 capsules in at least half a cup of water every 4 - 6 hours, if necessary.

    Maximum daily dose for adults: 4000 mg/day (8 capsules/day);

    Do not overdose;

    Do not use with other drugs containing paracetamol;

    The minimum distance of repeated dose: 4 hours.

    Children from 6 to 11 years old:

    Dissolve 250 - 500mg for at least half a cup of water for every 4 - 6 hours if needed;

    Maximum daily dose: 60 mg/kg of weight divided into several times, each time 10 - 15 mg/kg weight used for 24 hours;

    Do not overdose;

    Not used with other drugs containing paracetamol;

    Do not use more than 4 doses in 24 hours;

    Minimum dose distance: 4 hours;

    Maximum time of using drugs without advice from a doctor: 3 days.

    Children under 6 years of age: Do not recommend using drugs for children under 6 years old.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Signs and symptoms:

    may be at risk of poisoning, especially in patients with prolonged malnutrition and enzyme users. In particular, overdose can lead to death in these cases.

    Symptoms usually appear in the first 24 hours, including nausea, vomiting, anorexia, pale skin, uncomfortable and sweating.

    Overdose when taking a dose higher than 7.5 g of paracetamol in adults, or 140 mg/kg body weight in children will cause inflammation and destruction of liver cells, which can cause complete and non -recovery liver necrosis, leading to liver cell failure, metabolic acid infection and brain disease leading to coma and death.

    At the same time, there is an increase in liver transaminase levels (AST, ALT), lactate dehydrogenase and bilirubin along with decreased prothrombin levels, which can occur from 12 to 48 hours after taking the drug. The clinical symptoms of liver damage often become pronounced at the beginning after 1-2 days, and reach a maximum after 3-4 days.

    Treatment:

    Apply medical control measures as soon as an overdose occurs even when symptoms of overdose are not appearing.

    may need n-acetylcysteine ​​or methionine.

    High doses of sodium bicarbonate can cause symptoms in the gastrointestinal tract such as belching and nausea. Moreover, high -dose sodium bicarbonate can cause blood alkalization, need to monitor electrolytes and control patients appropriately.

    What to do when you forget 1 dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose and continue the Panadol drug calendar. Do not use double dose to compensate for missed dose.

    Side Effects

    The frequency of appearance is very rare:

  • Disorders of blood and lymphatic systems: reduced platelets, neutropenia, leukopenia;
  • digestive disorders: diarrhea, abdominal pain;
  • Disorders of skin and subcutaneous tissue: urticaria, erythema, rash, external pustules syndrome, acute skin necrosis syndrome, Stevens-Johnson syndrome; timely management.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindications:

    This drug is not used in the following cases:

    Know there is an allergy to paracetamol or with propacetamol hydrochloride (the precursor of paracetamol) or other ingredients of the drug.

    Severe liver disease or physical liver disease.

    phenylketonuria (a genetic disease detected at birth), due to aspartam.

    Integrity with fructose (because of the presence of sorbitol).

    Lack of glucose-6-phosphate dehydrogenase (G6PD).

    Be cautious when using

    in case of severe liver disease or kidney disease (consulting your doctor before using paracetamol).

    Anorexia, incorrect or corrosion, prolonged malnutrition (poorly liver glutathion reserves).

    Dehydration, reducing blood volume.

    Doctors need to warn patients on signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

    In patients with glutathione hypermath such as blood infections, using paracetamol may increase the risk of acid metabolism in the blood.

    If the symptoms are persistent, consult a doctor.

    To be out of reach of children.

    Each effervescent Panadol contains 427mg sodium (2 tablets containing 854mg sodium), so should not use Panadol 500mg effervescent pellets in patients with salt.

    Each effervescent Panadol contains 50mg of sorbitol. Do not use drugs for patients with rare genetic diseases in non -tolerance fructose.

    Panadol 500mg effervescent tablets containing aspartame, a source of phenylalanine. Patients with phenylceton - urinary should not use this drug.

    The ability to drive and operate machinery

    does not affect.

    Pregnancy

    Human and animal studies have not yet identified any risk of paracetamol for pregnancy or embryonic development.

    The period of breastfeeding

    Human studies with paracetamol cannot identify any risk for nursing or breastfed women. Paracetamol passed the placenta fence and was excreted into breast milk.

    Drug interaction

    Paracetamol prolonged use at normal daily dose increases the anticoagulant effect of warfarin and other types of cooumarin leading to an increased risk of bleeding; However, if you do not use these doses often, there is no significant effect.

    Concentrated use with phenytoin can lead to reduced paracetamol effectiveness and increase the risk of toxicity to the liver. Patients who are being treated with phenytoin should avoid large and/or prolonged paracetamols. Need to monitor patients on signs of toxicity for the liver.

    Probenecid may reduce nearly twice in paracetamol's clearance by inhibiting its conjugate with glucuronic acid. Paracetamol dose should be considered when used simultaneously with probenecid.

    salicylamid can extend the disposal time (t1/2) of paracetamol.

    Enzyme induction substances: Be careful when using paracetamol with liver enzyme induction substances such as barbiturat, isoniazid, carbamazepine, rifampicin and ethanol ...

    Storage

    Leave a cool dry place, avoid light, temperature below 30⁰C.

    To be out of reach of children.

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