Panadol Extra Red Panadol GSK tablet reduces pain, fever, headache treatment, back pain (15 blisters x 12 tablets)

Dosage form Tablet
Specifications Box of 15 blisters x 12 tablets
Ingredient Caffeine, paracetamol

Ingredient

Composition informationContent
Caffeine65mg
Paracetamol500mg

Uses

Indications

Panadol Extra Panadol -containing paracetamol is a fever, analgesic and caffeine is a enhancement of paracetamol analgesic.

Panadol is recommended to treat most mild to medium pain symptoms and fever, such as headaches, including migraine, back pain, toothache, joint pain and dysmenorrhea, reduced symptoms of colds, flu and sore throat.

Pharmacokology

Mechanism of action

paracetamol is an analgesic, antipyretic. The mechanism of action of the drug is thought to inhibit the synthesis of prostaglandin, mainly in the central nervous system.

caffeine acts as a painful relief substance of paracetamol. Caffeine pain relief effectiveness is thought to be a result of a number of mechanisms such as (I), blocking the peripheral pain effects of Adenosine, (ii) to activate the central noradrenergic glands to form a system of endogenous analgesic and (III) to activate the central nervous system leading to the regulation of affecting the composition of pain.

pharmacokinetic pharmacokinetics

paracetamol

absorption

Paracetamol is quickly absorbed from the digestive tract and distributed to most of the body's tissue.

Distribution

Paracetamol binds to plasma proteins very little at treatment concentration.

Metabolism

paracetamol is metabolized in the liver and excreted through urine mainly in the form of glucuronide and sulphate metabolites.

Elimination

less than 5% Paracetamol is excreted in a constant form. Average waste time in plasma is about 2.3 hours.

caffeine

absorption

caffeine is quickly absorbed from the gastrointestinal tract. After drinking, caffeine is completely and quickly absorbed from the digestive tract reaching the peak concentration between 5 and 120 minutes depending on the dose, health status and simultaneous use of dieters. There is no evidence of systemic metabolism.

Distribution

caffeine is widely distributed throughout the body. Caffeine binds with an average plasma protein about 35%.

Metabolism

caffeine is almost completely metabolized (about 99%) through the liver, through oxidation and reduction of methyl produce some xanthine derivatives, then excreted in urine. Cytochrome P450 isoenzyme CYP1A2 is associated with enzyme metabolism of caffeine.

Elimination

Caffein excreted almost entirely due to liver metabolism in adults. Only a small percentage (1 to 2%) The amount of caffeine absorbed in people is excreted in the form of unchanged in the urine. In adults, the body transformation is marked at the ratio of elimination occurs. The average selling time in plasma after drinking about 4.9 hours within 1.9 - 12.2 hours.

combined form

There is no saturation of the elimination process with the risk of increased half -life and toxicity of paracetamol. The absorption of both active ingredients (paracetamol and caffeine) as quickly as described in each individual pharmacokinetic properties. There is no interaction.

Before taking Panadol Extra Red Panadol GSK tablet reduces pain, fever, headache treatment, back pain (15 blisters x 12 tablets)

How to use

oral and oral drugs can be used when hungry.

Dosage

Adults (including the elderly) and children aged 12 and older

  • Should use 1 or 2 tablets every 4 to 6 hours if needed. (paracetamol/caffeine).

    Do not recommend this medication for children under 12 years old.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    paracetamol

    Signs and symptoms

    Experience shows that paracetamol overdose leads to clinical signs of liver damage usually occur after 24 hours to 48 hours and peak after 4 to 6 days.

    Overdose of paracetamol can cause liver failure, may require liver transplant or lead to death. Observed with acute pancreatitis, often accompanied by liver dysfunction and liver toxicity.

    Symptoms of overdose of paracetamol over the first 24 hours are pale, nausea, vomiting, anorexia and abdominal pain. Liver damage may be clear after drinking 12 to 48 hours. Glucose metabolic abnormalities and metabolic acidosis may occur. In case of severe poisoning, liver failure can progress into brain disease, hemorrhage, hypoglycemia, brain edema and death.

    Acute renal failure with acute renal necrosis, manifested as lumbar pain, urinary and proteinuria, may progress even without serious liver damage. There have been reports on arrhythmia and pancreatitis.

    Treatment

    Apply medical control measures as soon as an overdose occurs even when symptoms of overdose are not appearing.

    If the overdose is confirmed or suspected, immediately contact the Poison Control Center for advice and take the patient to the nearest medical emergency center for handling and professional treatment.

    Should be done even if the patient has no symptoms or signs of an overdose due to the risk of liver damage slowly.

    In case there is no toxic prevention center, take the patient to the nearest medical emergency center for handling and professional treatment.

    may need n-acetylcysteine ​​or methionine.

    caffeine

    Signs and symptoms

    Overdose of caffeine can cause epigastric pain, vomiting, hesitation, tachycardia, central nervous stimulation (insomnia, awake, agitation, confusion, panic, tremor, convulsions).

    When using an overdose, it should be noted that in addition to the symptoms that occur due to caffeine overdose can also cause serious toxicity to the liver due to paracetamol overdose.

    Treatment

    There is no specific detoxification but can use appropriate emergency measures such as using sympathetic beta receptor drugs to prevent heart toxicity.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    • Side Effects

    When using Panadol Extra, you may experience unwanted effects (ADR).

    Very rare, ADR

    paracetamol

    Blood disorders and lymphatic systems: platelets.

    The immune system disorder: Hypersensitivity reaction, skin sensitive reaction including: erythema, angioedema, Stevens - Johnson syndrome and toxic skin necrosis syndrome.

    Respiratory, chest and mediastinum disorders: bronchospasm in patients sensitive to aspirin and other NSAIDs.

    Liver disorders: Liver abnormalities.

    caffeine

    Central nerve: dizziness, headache.

    Heart disorders: constipation.

    Mental disorders: insomnia, restlessness, anxiety and discomfort, agitation.

    Digestive: digestive disorders.

    When using the recommended dose of Paracetamol-Caffeine, along with a diet high in caffeine, will cause side effects due to caffeine overdose such as insomnia, awake, anxiety, irritability, headache, digestive disorders, suspense.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Panadol Extra drugs are contraindicated in case the patient has a history of hypersensitivity to paracetamol, caffeine or any excipients of the drug.

    Precautions when using

    Doctors need to warn patients about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

    Not used with other drugs containing paracetamol.

    Timeless use of other drugs containing paracetamol can lead to overdose.

    Overdose of paracetamol can cause liver failure, which may need liver transplant or lead to death.

    Patients who are suffering from liver diseases, increasing the risk of paracetamol harmful to the liver. Consult your doctor before taking this medication for patients diagnosed with liver or kidney failure.

    Avoid using too much caffeine (such as coffee, tea and some other canned drinks) while taking this medication.

    The ability to drive and operate machinery

    does not affect the ability to drive and operate machinery.

    Pregnancy

    do not recommend using Panadol during pregnancy.

  • Paracetamol: As the use of any drug during pregnancy, pregnant women should find medical advice before using paracetamol. Should consider the lowest dose effectively and the shortest treatment time.

    Breastfeeding period

    Do not recommend medication during breastfeeding.

    paracetamol is excreted in breast milk but there is no clinical sign at the recommended dose.

    Caffeine in breast milk can have a stimulating effect on breastfeeding, but so far has not observed significant toxicity.

    Drug interaction

  • Paracetamol: Using daily paracetamol, prolonged increasing anticoagulant effects of Warfarin and other types of Coumarin leading to increased risk of bleeding. Using infrequent drugs will not have a significant effect. Therefore, it is not recommended to use these two drugs.

    • Storage

    Store in a dry place, temperatures below 30 ° C.

    Other drugs

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