Panadol Extra with Optizorb GSK tablets relieve pain, reduce fever quickly, do not cause drowsiness (12 blisters x 10 tablets)
Dosage form Film bag tablets
Specifications Box of 12 blisters x 10 tablets
Ingredient Paracetamol, caffeine
Indication Dysmenorrhea, cold, headache, migraine, body aches
Contraindication Anemia, heart failure
Ingredient
Thành phần cho 1 viên
| Composition information | Content |
| Paracetamol | 500mg |
| Caffeine | 65mg |
Uses
Indications
Panadol Extra with optizorb containing paracetamol is an antipyretic, analgesic and caffeine is a enhancement of paracetamol analgesic, indicated in the following cases:
Pharmacological effects: Analgesic and antipyretic.
Mechanism of action
paracetamol
paracetamol is an analgesic, antipyretic. The mechanism of action of the drug is thought to inhibit the synthesis of prostaglandin, mainly in the central nervous system.
caffeine
Caffeine pain relief efficiency is thought to be a result of a number of mechanisms such as (i), blocking the peripheral pain effect of Adenosine; (ii) Activation of central noradrenergic glands forming an endogenous pain relief system; and (iii) Activate the central nervous system leading to regulating the impact on the composition of pain.
Pharmacological effects
Due to the no effect of inhibiting peripheral prostaglandin, the drug has an important pharmacological properties of maintaining prostaglandin protected at the digestive tract. Therefore, Paracetamol is suitable for patients with a history of disease, or patients who are taking other drugs with side effects are inhibiting peripheral prostaglandin (for example, patients with a history of gastrointestinal bleeding or elderly people).
caffeine acts as a painful relief substance of paracetamol. The clinical data shows that the combination of paracetamol-caffeine causes much more pain relief effect than conventional paracetamol tablets (P ≤ 0.05).
pharmacokinetics
paracetamol
absorption
Paracetamol is quickly absorbed from the digestive tract and distributed to most body tissues.
Distribution
Paracetamol binds to plasma proteins very little at treatment concentration.
Metabolism
paracetamol is metabolized in the liver and excreted through urine mainly in the form of glucuronide and sulphate metabolites.
Elimination
less than 5% paracetamol is excreted in a constant form.
caffeine
absorption
caffeine is quickly absorbed from the gastrointestinal tract. After drinking, caffeine is completely and quickly absorbed from the digestive tract reaching the peak concentration between 5 and 120 minutes depending on the dose, health status and simultaneous use of dieters. There is no evidence of systemic metabolism.
Distribution
caffeine is widely distributed throughout the body.
Caffeine binds to an average plasma protein about 35%.
Metabolism
caffeine is metabolized almost completely (about 99%) through the liver through oxidation and reduction of methyl produce some xanthine derivatives, then excreted through urine.
Cytochrome P450 isoenzyme CYP1A2 is associated with enzyme metabolism of caffeine.
Elimination
Elimination is almost entirely due to liver metabolism in adults. Only a small percentage (1 to 2%) The amount of caffeine absorbed in people is excreted in the form of unchanged in the urine. In adults, the body transformation is marked at the ratio of elimination occurs. The average selling time in plasma after drinking about 4.9 hours within 1.9 - 12.2 hours.
Before taking Panadol Extra with Optizorb GSK tablets relieve pain, reduce fever quickly, do not cause drowsiness (12 blisters x 10 tablets)
How to use
Panadol Extra with Optizorb can be used when hungry.
Using oral only.
Do not overdose.
Should use the lowest dose necessary to be effective in the shortest treatment period.
Dosage
Adults (including the elderly) and children aged 16 and over:
Use 2 tablets/time, can be used 4 times a day. Do not use repeat dose more often every 4 hours.
Do not use more than 8 tablets in 24 hours.
Children from 12 - 15 years old:
Use 1 tablet/time, can be used 4 times a day. Do not use repeat dose more often every 4 hours. Do not use more than 4 tablets in 24 hours.
Do not recommend this medication for children under 12 years old.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?
paracetamol
Signs and symptoms
Experience shows that paracetamol overdose leads to clinical signs of liver damage usually occur after 24 hours to 48 hours and peak after 4 to 6 days.
Overdose of paracetamol can cause liver failure, may require liver transplant or lead to death. Observed with acute pancreatitis, often accompanied by liver dysfunction and liver toxicity.
Treatment
Apply medical control measures as soon as an overdose occurs even when symptoms of overdose are not appearing.
If the overdose is confirmed or suspected, immediately contact the Poison Control Center for advice and take the patient to the nearest medical emergency center for handling and professional treatment. Should be done even if the patient has no symptoms or signs of overdose due to the risk of liver damage slowly.
In case there is no toxic prevention center, take the patient to the nearest medical emergency center for handling and professional treatment.
may need n-acetylcysteine or methionine.
caffeine
Signs and symptoms
Overdose of caffeine can cause epigastric pain, vomiting, hesitation, tachycardia, central nervous stimulation (insomnia, awake, agitation, confusion, panic, tremor, convulsions).
When using an overdose, it should be noted that in addition to the symptoms that occur due to caffeine overdose can also cause serious toxicity to the liver due to paracetamol overdose.
Treatment
There is no specific detoxification but can use appropriate emergency measures such as using sympathetic beta receptor drugs to prevent heart toxicity.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.
Side Effects
When using Panadol Extra with Optizorb, you may experience unwanted effects (ADR).
data obtained from product circulation
Understanding effects based on clinical research data are rarely occurring and a few patients. The adverse effects obtained during the circulation of the product at the dose of treatment/labeling and are given in the table below according to the classification of the Meddra body system. The adverse reactions are determined during the circulation of products that are voluntarily reported from a population with unknown size, the frequency of these reactions is unknown but it may be very rare (
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
Panadol Extra with Optizorb is contraindicated in the case:
Be cautious when using
Doctors need to warn the patient about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute all -body pustular syndrome (AGEP).
Not used simultaneously with other drugs that contain paracetamol because it can lead to overdose.
Overdose of paracetamol can cause liver failure, which can lead to liver transplant or death. In patients who are suffering from liver diseases, there is an increase in the risk of paracetamol harmful to the liver. Consult your doctor before taking this medication for patients diagnosed with liver or kidney failure.
There has been a report on liver function impairment disorders in patients with glutathione deficiency such as malnutrition, serious anorexia, low body mass index or chronic alcoholic. Patients in a glutathione deficiency such as blood infections, using paracetamol may increase the risk of acid metabolism in the blood.
If the symptoms are persistent, consult a doctor.
Avoid using too much caffeine (such as coffee, tea and some other canned drinks) while taking this medication.
To be out of reach of children.
Sodium Methyl - Sodium Ethyl - and Sodium Propyl - Parahydroxybenzoate (E219, E215, E217) can cause allergic reactions (can be delayed).
The ability to drive and operate machinery
has no significant effect.
Use drugs for women during pregnancy and lactation
do not recommend the use of drugs during pregnancy.
paracetamol
As the use of any drug during pregnancy, pregnant women should find medical advice before using paracetamol. Should consider the lowest dose effectively and the shortest treatment time.
caffeine
It is recommended to use caffeine during pregnancy due to the ability to increase the risk of natural miscarriage associated with accumulation of caffeine in the body.
breastfeeding women
Do not recommend taking drugs during breastfeeding.
paracetamol
paracetamol is excreted in breast milk but there is no clinical sign at the recommended dose.
caffeine
Caffeine in breast milk can have a stimulating effect on breastfeeding, but so far has not observed significant toxicity.
Drug interaction
paracetamol
The daily use of daily paracetamol increases the anticoagulant effect of warfarin and other types of cooumarin leading to an increased risk of bleeding; Non -regular use will not have a significant impact.
caffeine
caffeine may increase lithium elimination from the body. Therefore, it is not recommended to use these 2 medications.
Storage
Storage below 30 ° C.
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