Panadol GSK effervescent tablets relieve mild pain and fever (6 blisters x 4 tablets)

Dosage form Effervescent
Specifications Box of 6 blisters x 4 tablets
Ingredient Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

indications

Panadol 500 drugs are indicated in the following cases:

Paracetamol is a mild and fever -reducing medicine. The drug is recommended to treat most of the symptoms of pain and fever such as headache, including migraine and headache due to stress, toothache, back pain, joint pain, muscle pain, dysmenorrhea, sore throat, and fever, reducing the flu.

Pharmacological effects: Anilides.

Mechanism of action

paracetamol is an analgesic, antipyretic. The mechanism of action of the drug is thought to inhibit the synthesis of prostagladin, mainly in the central nervous system.

Pharmacological impact

Due to the no effect of inhibiting peripheral prostagladin, the drug has an important pharmacological properties of maintaining prostaglandin protected at the digestive tract. Therefore, Paracetamol is suitable for patients with a history of disease, or patients who are taking other drugs with side effects are inhibiting peripheral prostaglandin (e.g. rings with a history of gastrointestinal bleeding or the elderly).

Unknown sodium bicarbonate has analgesic activity.

Dynamic pharmacokinetics

absorption

Paracetamol is absorbed quickly and almost completely from the digestive tract. The concentration of the drug in plasma is maximum for 30 to 60 minutes and the half -life is from 1 to 4 hours.

distribution

At the treatment concentration, paracetamol binds very little with plasma proteins.

transformation

paracetamol is metabolized in the liver and excreted in urine mainly in the form of glucuronide and sulphate.

Elimination

less than 5% paracetamol is excreted in a constant form.

In a pharmacokinetic study in volunteers, the maximum serum concentration achieved after 20 minutes (average TMAX) in a state of hunger and significantly faster than the standard Paracetamol Institute (P = 0.007). The absorption speed for the first 20 minutes after the drug (AUC0-20 minutes) is significantly greater than that of the standard Paracetamol tablet releases instantaneous drugs (P = 0.0028). The absorption level (AUC0-inF) is equivalent to the Paracetamol tablet standard to release instant drugs in a state of hunger.

Before taking Panadol GSK effervescent tablets relieve mild pain and fever (6 blisters x 4 tablets)

How to use

Ineroden, dissolved pills into water, oral use.

Do not overdose.

Should use the lowest dose necessary to be effective in the shortest treatment period.

Dosage

Adults, elderly people and children aged 16 and over:

Dissolve 1-2 capsules in at least half a cup of water, use up to 4 times a day if needed.

Children from 10 to 15 years old:

Dissolve 1 capsule in water, use up to 4 times a day.

Do not recommend taking drugs for children under 10 years old.

Do not give children medicine for more than 3 days without a doctor's advice.

Paracetamol dose should not be used more often every 4 hours and do not use more than 4 doses in 24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Liver damage can occur in adults who have used 10 g paracetamol or more. Swallowing 5 g of paracetamol or more can lead to liver damage if the patient has risk factors.

Risk factors:

If the patient is under long -term treatment with carbamazepine, phenobarbitone, phenytoin, primidone, rifampicin, st John's wort or other drugs that stimulate liver enzymes.

Or regularly using ethanol exceeding recommended dose.

either capable of depleting glutathione, for example: digestive disorders, cystic fibrosis, HIV, hunger, weakness.

Symptoms of overdose:

Symptoms of paracetamol overdose in the first 24 hours are pale, nausea, vomiting, anorexia and abdominal pain. Liver damage may appear 12 to 48 hours after drinking. Abnormal glucose metabolism and metabolic acidosis may occur. In case of severe poisoning, liver failure can progress into brain disease, hemorrhage, hypoglycemia, brain edema and death. Acute renal failure with acute renal necrosis, suggested such as lumbar pain, blood urination and proteinuria, can grow even without serious liver damage. Cardiac arrhythmia and pancreatitis have been reported.

How to handle:

Immediately treatment is essential in paracetamol overdose control. Despite the lack of significant early symptoms, patients should be transferred to the hospital for emergency hospital for immediate medical care. Symptoms may be limited as nausea or vomiting and may not reflect the severity of overdose or the risk of internal organs. The control must be in accordance with the established treatment instructions, see the overdose of BNF.

Treatment with activated carbon should be considered if the overdose occurs within 1 hour. Paracetamol concentration in plasma should be measured at 4 hours or later after the urea (earlier concentration is not reliable). N-acetylcystein treatment may be used up to 24 hours after taking paracetamol, however, the maximum protection effect reaches up to 8 hours after drinking.

The effectiveness of antidote decreases sharply after this time. If required, patients should be intravenously N-acetylcysteine intravenously, in accordance with the schedule set. If vomiting symptoms are not a problem, oral methionine can be an appropriate alternative for remote areas, outside the hospital.

Patient control with serious liver dysfunction after 24 hours of drinking should be discussed with NPIS or liver unit.

High doses of sodium bicarbonate can cause gastric - intestinal syndrome including belching and nausea.

Moreover, high doses of sodium bicarbonate can cause hypercassemia; Patients should be monitored electrolyte and appropriate control.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Panadol 500 medicine, you may experience unwanted effects (ADR):

Unwanted effects obtained from the data of clinical trials are often rare and occur on a few patients. Therefore, please give in the table below the unwanted effects obtained during the product circulation at the dose of treatment according to the classification of the body's organ system and the frequency of appearance.

To classify the level of unwanted effects, use the following conventions: Very popular (≥ 1/10), popular (≥ 1/100, The frequency of unwanted effects that are estimated from the reports obtained from post -marketing data.

unwanted effects frequency

grain leukemia

Very rare

Sensitive reaction on the skin includes erythema, angioedema.

There have been very rare reports that occur cases seriously on the skin.

Very rare Cases of bronchospasm when taking paracetamol, but these cases are more likely in patients with asthma sensitive to aspirin or other NSAIDs.

Reports on suspicious adverse reactions

The adverse response report is suspected after circulating the drug products is important. This allows to continue monitoring the balance between the benefits and risks of the drug products. Health care experts are required to report any adverse reactions that are suspected through Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search Yellow Card MHRA in Google Play or Apple App.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Panadol 500 drugs contraindicated in the following cases:

Contraindicated to use paracetamol for patients with a history of paracetamol hypersensitivity or any excipients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Doctors need to warn the patient about signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas pustular syndrome (AGEP). Do not use with other drugs that contain paracetamol. Patients diagnosed with liver failure or kidney failure consult a doctor before taking this medication. Contains 854 mg of sodium). Patients with salt should be considered when using the drug. Do not use drugs for patients with rare genetic diseases in non -tolerant fructose.

If the symptoms are persistent, consult a doctor.

The effect of the drug on the ability to drive and operate machinery

The drug does not seem to affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

This drug should only be used if the expected benefit for the mother is superior to the potential risk for the fetus.

Epidemiological studies on nerve development in children in contact with paracetamol in the fetus shows no results. Paracetamol can be used during pregnancy if necessary in terms of clinical, however, such as using any drug during pregnancy, should only use the drug in the lowest doses that are effective in the shortest time.

breastfeeding women

Paracetamol is excreted through breast milk but does not have clinical significance at the recommended dose. The published data shows no contraindications for breastfeeding.

Drug interaction

Paracetamol's absorption rate may be increased by metoclopramide or domperidone and the absorption decreased by Colestyramine.

The daily use of daily paracetamol increases the anticoagulant effect of warfarin and other types of cooumarin leading to an increased risk of bleeding; Non -regular use will not have a significant impact.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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