Panadol Panadol tablet GSK reduces symptoms of flu, fever, pain and nasal congestion (15 blisters x 12 tablets)

Dosage form Film bag tablets
Specifications Box of 15 blisters x 12 tablets
Ingredient Acetaminophen, caffeine, phenylephrine
Indication Rhinitis, allergic rhinitis, sinusitis, fever, colds, headache
Contraindication Chronic alcoholism, anemia

Ingredient

Thành phần cho 1 viên

Composition informationContent
Acetaminophen500mg
Caffeine25mg
Phenylephrine5mg

Uses

Indications

Panadol of the flu is indicated to reduce the symptoms of the flu, such as fever, pain and nasal congestion.

Pharmacokological

paracetamol

paracetamol is an effective analgesic and antipyretic but has weak anti -inflammatory properties. Its impact mechanism is not fully understood. There has been a hypothesis that the main impact mechanism of paracetamol may be by inhibiting prostaglandin synthesis on the central nervous system and at a lower level through peripheral effects by preventing painful impulses.

Peripheral effects may also be due to prostaglandin synthesis or due to inhibition of synthesis or the impact of other substances that cause pain -irritating receptors to irritate mechanical or chemicals. Paracetamol has an antipyretic effect due to the central effect on the cooling center in the hypothalamus, creating peripheral vasodilation leading to increased blood flow through the skin, sweating and loss of heat. The central impact is probably related to the synthesis of prostaglandin in the hypothalamus. The drug has no effect on the cardiovascular and respiratory system, and unlike the salicylate group, the drug does not cause irritation or stomach bleeding.

caffeine

caffeine acts as a painful relief substance of paracetamol. Clinical data shows that the combination of paracetamol - caffeine causes a much better pain relief effect than conventional paracetamol tablets (p

phenylephrine hydrochloride

Phenylephrine hydrochloride is a sympathetic nerve stimulant, the main effect and directly on the adrenergic receptor (mostly alpha-adrenergic), which has an anti-nasal congestion effect. It is used to treat nose congestion symptoms that come with a cold and flu.

pharmacokinetics

paracetamol

Paracetamol is absorbed quickly and almost completely from the digestive tract and distributed to most of the body's tissue. At treatment concentration, paracetamol is very small with plasma proteins. Paracetamol is metabolized in the liver and excreted in urine mainly in the form of glucuronide and sulphate metabolites - less than 5% paracetamol excreted in a constant form. The average selling time in plasma is about 23 hours.

caffeine

Caffeine is quickly absorbed from the digestive tract and is widely distributed throughout the body. Caffeine is metabolized almost entirely through the liver through oxidation and reduction of methyl produce some Xanthine derivatives, then excreted through the urine. The average selling time in plasma is about 4.9 hours.

phenylephrine

Phenylephrine is unevenly absorbed from the digestive tract. Phenylephrine experienced the first metabolism process by monoamine oxidases in the liver cycle. Phenylephrine is taken orally, thus reducing bioavailability. Phenylephrine is excreted in urine almost entirely in the form of sulphate.

Before taking Panadol Panadol tablet GSK reduces symptoms of flu, fever, pain and nasal congestion (15 blisters x 12 tablets)

How to use

Take oral use.

Do not overdose indicated.

Should use the lowest dose necessary for treatment effect.

Dosage

Adults (including the elderly) and children 12 years and older:

Should use 1 or 2 tablets (500 mg Paracetamol/25 mg caffeine/5 mg phenylephrine hydrochloride up to 1000 mg of paracetamol/50 mg caffeine/10 mg phenylephrine hydrochloride) at each time, can be used up to 4 times/day.

Maximum daily dose: 8 tablets (4000 mg of paracetamol/200 mg caffeine/40 mg phenylephrine hydrochloride) in 24 hours.

About minimum doses: 4 hours.

Maximum time for using fever does not have a doctor's prescription: 3 days.

Children under 12 years:

Do not recommend this medication for children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

paracetamol

Symptoms and signs

Overdose of paracetamol can cause liver failure. The symptoms of paracetamol overdose in the first 24 hours are pale, nausea, vomiting, anorexia and abdominal pain. Liver damage may be clear after drinking 12 to 48 hours. Glucose metabolic abnormalities and metabolic acidosis may occur. In case of severe poisoning, liver failure may progress into brain disease, hemorrhage, hypoglycemia, brain edema and death. Acute renal failure with acute renal necrosis, manifested as lumbar pain, urinary and proteinuria, may progress even if there is no serious liver damage. There have been reports on arrhythmia and pancreatitis.

Treatment

Immediately treatment is necessary in the treatment of paracetamol overdose. Although there are no early symptoms, patients should be taken to the emergency hospital for medical care immediately. Symptoms may be limited to nausea or vomiting and do not reflect the severity of overdose or the risk of organ damage. Treatment must follow with the established treatment instructions.

Treatment with activated carbon should be considered if the overdose occurs within 1 hour. Plasma paracetamol concentrations should be measured after drinking 4 hours or later (the previous concentration is unreliable). It is possible to treat with n-acetylcystein until 24 hours after taking paracetamol, however, the maximum protection effect is achieved after drinking within 8 hours.

The effectiveness of antidote decreases sharply after this time. If necessary, patients should be intravenously n-acetylcysteine ​​intravenously, suitable for the schedule of the set of sets.

If vomiting is not a problem, oral methionine can be an alternative suitable for hospitals.

The treatment of patients with severe liver dysfunction after 24 hours of overdose should be discussed with the National Poisoning Center or a hospital specializing in liver disease.

caffeine

Symptoms and signs

Overdose of caffeine can cause epigastric pain, vomiting, hesitation, tachycardia, central nervous stimulation (insomnia, awake, agitation, confusion, panic, tremor, convulsions).

When using an overdose, it should be noted that in addition to symptoms that occur due to caffeine overdose, there may be serious toxicity to the liver due to paracetamol overdose.

Treatment

There is no specific detoxification but can use supportive treatments.

phenylephrine

Symptoms and signs

Overdose of phenylephrine seems to cause the same effects as listed in the unwanted effects.

There may also be other symptoms such as irritability, awakening, hypertension, and may be slowly reflexive heart rate. In severe cases can lead to confusion, hallucinations, stroke and arrhythmia.

However, the amount of drugs that can be serious toxicity related to phenylephrine is usually greater than the amount of drugs that may cause serious toxicity in the liver related to paracetamol.

Treatment

Treatment should depend on clinical symptoms. Hypertension should be treated with alpha blockers like Phentolamine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Panadol flu, you may experience unwanted effects (ADR).

paracetamol

Unwanted effects obtained from the data of clinical trials are often rare and occur on a few patients.

Therefore, the unwanted effects obtained during the circulation of the product in the recommended dose are given in the table below according to the body system of the body. Because these unwanted effects are voluntarily reported and from a large number of unknown, the frequency of appearance is considered very rare (

Blood disorders and lymphatic systems: platelets.

immune system disorders: Hypersensitivity reactions, skin allergies such as erythema, angioedema, Stevens - Johnson syndrome.

Respiratory, chest and mediastinum disorders: bronchospasm in patients sensitive to aspirin and other NSAIDs.

Liver disorders: Liver abnormalities.

caffeine

The unwanted effects obtained during the circulation of products related to the use of caffeine are listed below. The frequency of these unwanted effects cannot be determined.

Central nervous system: restlessness, dizziness.

When using the recommended dose of Paracetamol-Caffeine, along with a diet high in caffeine, there may be side effects due to caffeine overdose such as insomnia, awake, anxiety, irritability, headache, digestive disorders, suspense.

phenylephrine

The undesirable effects below have been encountered in clinical trials with phenylephrine and may be representing the most unwanted effects. These unwanted effects are divided by the body system (Meddra).

Mental disorders: restlessness.

Disorders on the nervous system: headache, dizziness, insomnia.

Disorders on the heart: hypertension.

Disorders on the gastrointestinal tract: nausea, vomiting.

below please list the unwanted effects obtained during the product circulation. The frequency of these unwanted effects is not clearly defined but it seems rare (

  • Eye disorders: Persian dilatation, acute angle glaucoma, often occurs in patients with a history of closed angle Glaucoma (see caution and special notes/contraindications).
  • heart disorders: tachycardia, nervousness.
  • Skin and subcutaneous disorders: allergic reactions such as rash, urticaria, atopic dermatitis.
  • Kidney and urinary disorders: urinary pain, urinary retention. Often occurs in patients with urinary tract congestion such as patients with prostate hypertrophy.

    • Instructions on how to handle ADR

    When experiencing side effects of the flu -cold Panadol, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the fluadol drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Panadol flu medicine is contraindicated in the following cases:

    There is a history of hypersensitivity to paracetamol, caffeine, phenylephrine or any excipients of the drug.

    Patients are taking or used in the last 2 weeks of monoamine oxidase inhibitors. Glaucoma closed angle, used with other drugs containing other sympathetic ingredients, pheoochromocytoma, liver failure, severe kidney failure, heart disease, diabetes, blood pressure, hyperthyroidism.

    Precautions when using

    Doctors need to warn patients on signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

    Contains paracetamol. Do not use with other drugs that contain paracetamol, anti -congested drugs and other anti -flu drugs. Simultaneous use of other drugs containing paracetamol can lead to overdose. Paracetamol overdose can cause liver failure, which can lead to liver transplant or death.

    There has been a report on liver function disorders/impairment in patients with glutathione deficiency such as malnutrition, serious anorexia, low body mass index or chronic alcoholic.

    Consult your doctor before taking this medication for patients who are suffering from the following diseases:

    High blood pressure.

    Cardiovascular disease.

    diabetes.

    hyperthyroidism.

    Glaucoma closed angle.

    phaeochromocytoma.

    Prostate hypertrophy.

    Clogged vascular disease (such as Raynauds syndrome).

    impaired liver or kidney function. There is an increase in the risk of Paracetamol's harmfulness to the liver in patients who are suffering from liver diseases.

    Patients in a glutathione deficiency such as blood infections, using paracetamol may increase the risk of acid metabolism in the blood.

    Be cautious when taking medications for patients who are taking beta blockers, and other antihypertensive drugs.

    Be cautious when taking the drug for patients who are taking 3 -round antidepressants.

    Do not use medications for patients who are taking sympathetic nerve stimulants (such as anti -congested drugs, diet drugs and nerve stimulants like Amphetamine).

    Avoid using too much caffeine (such as coffee, tea and some other canned drinks) while taking this medication.

    If the symptoms are persistent to consult a doctor.

    To be out of reach of children.

    The drug contains Eurocol Sunset Yellow (E110), which can cause allergic reactions.

    The ability to drive and operate machinery

    Patients with dizziness due to the use of the flu should not drive and operate machinery.

    Pregnancy

    Reproduction ability: No data.

    Pregnant women: Do not recommend this medication for pregnant women.

    paracetamol: Human and animal studies have not yet identified any risk of paracetamol for pregnancy or embryo development.

    caffeine: It is not recommended to use this drug during pregnancy due to the ability to increase the risk of natural miscarriage associated with accumulation of caffeine in the body.

    phenylephrine: No data.

    Breastfeeding period

    If there is no doctor's prescription, you should not use this medication during breastfeeding.

    Paracetamol: Human studies with paracetamol at the recommended dose do not identify any risk for nursing women or breastfeeding.

    caffeine: Caffeine in breast milk may have a stimulating effect for breastfeeding but have not observed significant toxicity.

    phenylephrine: can be excreted in breast milk.

    Drug interactions

    Clinical significant drug interactions may occur. It is necessary to consult a doctor before using a combination of paracetamol-caffeine-phenylephrine with the following drugs:

  • Monoamine inhibitors: Drug interaction leads to hypertension between oxidase amines stimulating sympathetic nerves such as phenylephrine with monoamine oxidase inhibitors (see the contraindication section). Circuit (see carefully and special notes).
  • Beta blockers and other antihypertensive drugs (including Debrisoquine, Guanethidine, Reserpine, Methyldopa): Phenylephrine can reduce the effectiveness of beta blockers and other lower blood pressure drugs. The risk of hypertension and unwanted effects on the cardiovascular system can increase (see the internal kidney and special notes).
  • Digoxin and heart glycoside: simultaneous use of phenylephrine with digoxin or heart glycosides may increase the risk of abnormal heart rate or stroke. Non -regular drugs will not have a significant effect.

    • Storage

    Store in a dry place, temperatures below 30 ° C.

    Other drugs

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