Panfor SR-750 mega drug control type 2 diabetes (100 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Metformin

Ingredient

Composition informationContent
Metformin750mg

Uses

Indications

Panfor sr 750mg indicated treatment in the following cases:

  • Panfor SR is indicated as a support for diet and exercise to control blood sugar in adults with type 2 diabetes. Hyperglycemia, has the effect of improving glucose tolerance level in insulin (type 2 diabetes), reduces plasma glucose levels both after eating and basic concentration. The mechanism of action is not the same as the sulfonylurea group. Metformin works through 3 mechanisms:
  • metformin reduces the production of glucose in the liver by inhibiting the new glucose and glycogen award. Blood in both diabetics and no diabetes, does not cause increased blood insulin. When treated with metformin, the secretion of insulin is still normal while the amount of insulin is hungry and the plasma insulin corresponds to the day may decrease.

    Dynamic pharmacokinetics

    absorption and bioavailability

    After oral use, the slow -formin meture is slow to reach the peak concentration in the blood after 7 hours, for about 4-8 hours. After repeating slow release, Metformin does not accumulate in plasma. Although the absorption time of Metformin is slow to increase nearly 50% when used with food, it does not affect CMAX and TMAX.

    Distribution

    After taking orally 850mg metformin, the distribution voltage reaches 654 ± 358 L. Metformin Hydrochlorid is almost no cohesion to plasma proteins. At the usual dose of treatment, Metformin reaches a stable plasma concentration after 24-48 hours with a value of

    Metabolism and elimination

    metformin is almost intact through urine without being metabolized through the liver or excreted through bile.

    Nephrotic clearance is nearly 3.5 times higher than the creatinine clearance, which shows that the excretion through the tube is the main elimination sugar of Metformin.

    After taking the dose, about 90% of the absorption drug is excreted through the kidney within the first 24 hours, with a half -blood sale time of about 17.6 hours.

    • Before taking Panfor SR-750 mega drug control type 2 diabetes (100 tablets)

    How to use

    Panfor SR 750mg The type of release tablet is slow to use orally. Should take medicine after eating.

    Swallow the whole pill, not chewed.

    Dosage

    The dose of Panfor SR should be determined for each patient, depending on the level of intake and effect of the drug on each patient. Do not exceed the recommended dose of up to 2000mg/day.

    start at low doses and then slowly raise to reduce side effects on the digestive tract and determine the minimum dose needed to effectively control blood sugar for each patient.

    When starting to treat and during the appropriate dose determination should be tested for hunger during hunger to assess the level of treatment and determine the minimum effective dose for patients. After that, the hemoglobin glycosylate test should be tested every 3 months.

    The purpose of treatment is to reduce blood sugar at the same time and reduce the value of hemoglobin giycosylate to normal or near normal when using the minimum effective dose.

    It is possible to treat short -term treatment for drugs during poor glycemic control in patients who regularly control blood sugar by diet.

    Normal starting dose Panfor SR is 500mg/time/day during dinner. The level of expenditure increases should be added for an additional 500mg per week and up to 2000mg/day. If you do not reach a blood sugar control level at a dose of 2000mg/ time/ day, you should try at a dose of 1000mg x 2 times/ day.

    The starting dose of Panfor SR in patients shifting from the form of Metformin instant release to slow release is equivalent to each other. Patients who have been treated at a dose of 2000 mg metformin per day are not necessary to switch to slow release.

    If you plan to transfer from another diabetes medication, it is necessary to stop using this medication and use Panfor SR with the dose as instructed above.

    Collaborate with insulin: Metformin and insulin can be combined to achieve better blood sugar control.

    The starting dose of Panfor SR is 500mg/time/day, and the dose of insulin is adjusted depending on blood sugar.

    Children: Do not recommend using Panfor SR in children under 17 years old.

    Elderly. Metformin dose should be adjusted based on kidney function because there may be impaired renal function in the elderly. Carefully evaluate the kidney function regularly.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? Overdose or the accompanying risks of Metformin can cause lactic acidic acidosis.

    Lactic acidic acidosis is an emergency case and must be hospitalized for treatment. The most effective method for eliminating lactate and metformin is the hemorrhage.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    Unwanted effects (ADR) when using Panfor SR 750mg that you may encounter:

    The most unwanted effects are nausea, vomiting, diarrhea, abdominal pain, loss of appetite.

    The unwanted effects of the drug are listed below according to the classification of the body's organ system and the frequency of encounter. The frequency is determined as follows: Very common (> 1/10), common (≥1/100 and

    metabolism and nutrition:

    Very rare:

  • Lactic acid infection. It is necessary to consider as a pathology if the patient has a huge manifestation of red blood cell anemia.

    • Nervous system:Common

  • Intense disorders.

    • Digestive system:

    Very common:

  • Gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, reduced appetite.

    Very rare:

  • Separate reports on abnormal liver function tests or hepatitis are improved when stopping metformin.

    • Skin and subcutaneous tissues:

    Very rare:

  • Skin reactions such as erythema, itching, urticaria.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Panfor SR 750mg Panfor SR contraindicated in the following cases:

  • Patients with liver or kidney failure, alcoholism, diabetes are not dependent on insulin complications infection and severe acid, charm and coma. or the ingredients of the drug.

    • Be cautious when using

    for patients using metformin, it is necessary to monitor subclinical tests regularly, including blood sugar quantification, to determine the minimum metformin dose effective. Patients need information about the risk of lactic acid infection and circumstances to lead to this condition.

    Patients need to be recommended to regulate diet, because nutrition is treated as an important stage in the management of diabetes. Metformin treatment is only considered support, not to replace the regulation of a reasonable diet.

    metformin is excreted mainly through the kidneys, the risk of accumulation and lactic acid infection increases according to the degree of renal function.

    Metformin is not suitable for the treatment of the elderly, often with impaired renal function, so serum creatinine must be checked before starting treatment.

    Must stop treatment with Metformin 2-3 days before the X-ray projection uses iodine-containing contrast substances, and for 2 days after the projection. Only use back to metformin after re -evaluation of the kidney function is normal.

    There is a notice that the use of oral medications for diabetes increases cardiovascular mortality, compared to the treatment with a simple diet or insulin combination with a diet.

    Concomitance of drugs that affect the kidney function (affecting the excretion in the renal tubules) may affect the distribution of metformin.

    Metformin must be stopped when performing surgery. Do not use metformin for patients with liver function.

    Metformin must be stopped 48 hours before all surgical interventions need body anesthesia or anesthesia depending on living or around the epidural. Only re -use Metformin 48 hours after intervention or re -eating by mouth and after sure the kidney function has returned to normal.

    The drug can cause vitamin B12 deficiency and cause huge red blood cell anemia.

    Pregnant and lactating women

    pregnancy

    Metformin is contraindicated for pregnant women. During pregnancy, diabetes must always be treated with insulin.

    Breastfeeding period

    Not used for breastfeeding women.

    The effect of the drug on driving and operating machinery

    metformin does not affect the ability to drive and operate machinery. When combining metformin with other drugs to treat diabetes, blood glucose can occur, need to be cautious when operating machinery or train driving.

    Drug interaction

    Furosemid increases the maximum concentration of Metformin in plasma and in the blood without changing the kidney clearance coefficient of Metformin in the study using a single dose.

    Metformin has the ability to interact with cationic drugs (amilorid, digoxin, morphine, process, quinidine, quinin, ranitidine, triamteren, trimethoprim and vancomycin) due to competition through the general system in the renal tubules.

    Alcohol: Do not drink alcohol when using Metformin because of the increased risk of lactic acidic acidosis.

    Acarbo

    cimetidin: Avoid coordinating metformin with cimetindin due to the peak concentration of metformin in plasma and in the blood in total.

    nifedipin: Use at the same time Metformin and Nifedipin in healthy people increase the absorption and increase the metformin excretion through the urine.

    Hyperglycemia drugs such as thiazid, corticosteroids can lead to loss of blood control.

    Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

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