Pantin 40 Heterero tablets treat esophageal ulcer (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Pantoprazol

Ingredient

Composition information	Content
Pantoprazol	40mg

Uses

Indications

Pantin 40 drugs are indicated in the following cases:

Esophageal ulcer accompanied by gastroesophageal reflux disease (GERD): Pantoprazol tablets are intended to be treated (lasting up to 8 weeks) to cure and relieve symptoms of esophageal ulcer on adults and children aged 5 and older. For patients who have not been cured after 8 weeks of treatment, they can consider using an additional pantoprazole for another 8 weeks. The safety of the treatment has not been evaluated for more than 8 weeks of treatment in children.

Treatment of maintenance of esophageal ulcer: Pantoprazol tablets are indicated for maintenance of esophageal ulcer and reduce the recurrence of day and night belching symptoms in gastroesophageal reflux patients (GERD) in adults. Verified studies do not last more than 12 months.

Pathological secretions include Zollinger - Ellision: 40mg pantoprazol tablets used for long -term treatment of pathological secretion, including Zollinger - Ellision syndrome.

Pharmacy

Pantoprazol is a proton pump inhibitor. The drug in the acid secretary tubes of the stomach walls to be converted into activated sulfenamid, this form is associated with the HK-ATPASE enzyme (also known as the proton pump) on the surface of the cell into the stomach, inhibiting this enzyme, preventing the final step of the acid secretion into the stomach.

So Pantoprazol has the effect of inhibiting the basic acid secretion and even when the stomach is irritated by any stimulating agent. The effect of pantoprazol depends on the dose, the time to inhibit the excretion of gastric acids lasts more than 24 hours, although the half -life of excretion of Pantoprazol is much shorter (0.7 - 1.9 hours).

After the oral dose starts 40mg of pantoprazol, the excretion of gastric acid is inhibited an average of 51% after 2.5 hours. Take Pantoprazol once a day 40mg in 7 days reduces up to 85% of gastric acid excretion. Excreting stomach acid back to normal within 1 week after stopping pantoprazol and there is no phenomenon of hygiene (rebound). In addition, Pantoprazol can eliminate Helicobacter pylori in the stomach with a duodenal ulcer and/or reflux esophagitis contaminated with such bacteria. In vitro pantoprazole reduces the number of H. pylori more than 4 times in PH4.

pharmacokinetic

absorption

Pantoprazole absorbs fast, reaching the highest concentration in the blood after drinking about 2 - 2.5 hours. Pantoprazol is absorbed well, less initially metabolized in the liver, oral use about 77%.

Distribution

Pantoprazol is strongly attached to plasma proteins (98%), the volume of distribution in adults is 0.1 liters/kg. The prolonged time to prevent gastric acid secretion when intravenously pantoprazol is 24 hours. After an intravenous injection of a single dose of 20 to 120mg, the drug effect starts within 15-30 minutes and the effect within 24 hours depends on the dose of 20 - 80mg. Within 2 hours after the injection of 80 ng, the acid excretion flow is completely removed. The dose of 120mg also does not increase the effect.

Metabolism

Pantoprazole metabolizes mainly in the liver thanks to the cytochrom P450 enzyme system, isoenzyme CYP2C19 to convert it into Desmethylpantoprazol. A small part is metabolized by CYP3A4, CYP2D6, CYP29. In some people deficienced, the genetic CYP2C19 enzyme system (Asians are 17 - 23% of slow metabolism), which slowly metabolize pantoprazol, leading to a plasma concentration in plasma may increase 5 times higher than people with enough enzymes.

Elimination

The half -life of pantoprazol elimination is 0.7 - 1.9 hours, prolonged in people with liver failure, cirrhosis (3 - 6 hours) or slow -metabolic metabolic people (3.5 - 10 hours). The metabolites excreted mainly through the kidneys (about 80%), 18% through the bile into the feces.

Before taking Pantin 40 Heterero tablets treat esophageal ulcer (3 blisters x 10 tablets)

How to use

Pantoprazol 40mg tablets need to be swallowed intact with water, when full as well as hungry. If the patient does not swallow 40 mg tablets, can swallow two tablets 20 mg.

Used with antacids does not affect the absorption of pantoprazol. Patients should remember that 40mg pantoprazol tablets are not broken, broken, suck, suck or chew.

Dosage

recommended dose for adults:

Treatment of esophageal ulcer: The recommended oral dose for adults is 40 mg once a day lasting up to 8 weeks, with a patient that has not been cured after 8 weeks can consider using pantoprazol for another 8 weeks.

Treatment for maintenance of esophageal ulcer:

The recommended oral dose for adults is to take a 40mg of pantoprazol a day.

Pathological secretion state includes Zollinger-Elision syndrome: Pantoprazol dosage for patients in the state of increased pathology changes with individuals. The recommended starting dose for adults is 40 mg each time, twice a day. The dosage mode can be adjusted according to the state needs of each patient and need to last depending on clinical indications. There are 240 mg daily. Some patients have been treated continuously with Pantoprazol for more than 2 years.

No dose adjustment for patients with renal impairment, liver failure and elderly patients. The dose is higher than 40 mg/day has not been studied in patients with liver failure. No dose adjustments in patients are dialysis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case of overdose with clinical signs of poisoning, common detoxifications need to be applied.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Pantin 40, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: Tired, dizziness, headache.

Skin: skin, urticaria. digestive: dry mouth, nausea, vomiting, flatulence, abdominal pain, constipation, diarrhea.

Muscle joints: muscle pain, joint pain.

Uncommon, 1/1000

Body: weakness, dizziness, insomnia.

Skin: itching.

Liver: Increased liver enzyme.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pantin 40 drugs are contraindicated in cases with patients sensitive to any component of the drug.

Precautions when using

caution pantoprazol does not specify cases where mild gastrointestinal diseases feel difficult to digest.

It is necessary to eliminate the malignant abilities of gastric ulcer and malignant esophagus before treatment with pantoprazol because Pantoprazol reduces malignant ulcer symptoms and can actually make delayed diagnosis.

The ability to drive and operate machinery

Side effects such as dizziness, headache, chicken sleep and hallucinations may occur. Patients should not drive or operate machinery if they feel these symptoms.

Pregnancy

Clinical experiences for pregnant women are very limited. Pantoprazol is only used for pregnant women when really necessary.

Breastfeeding period

discovered the excretion of Pantoprazol by breast milk. Need to consider or not use medication or stop breastfeeding, taking into account the benefits of the drug for the mother.

Drug interaction

There is no report related to drug interactions in clinical.

Pantoprazol does not react with the Cytochrome P450 system. No drug interaction has been reported in a series of reaction tests with birth control pills, diazepam, diclofenac, ethanol, caffeine, metoprolol, digoxin, phenytoin, nifedipine, carbamazepine, glibenclamide and warfarin.

It also has no interaction when using antacids simultaneously. Nor in clinically, the interactions of Pantomed with the following antibiotics (clarithromycin, metronidazol, amoxycilin).

As well as other proton pump inhibitors, Pantoprazol can reduce the absorption of some drugs that their absorption depends on the stomach pH such as ketoconazol, iTraconazole.

Severe muscle pain and bone pain may occur when using methotrexat along with Pantoprazol.

Storage

Store at temperatures below 30 ° C, avoid moisture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.