Pantonix 40 Incepta Treatment of Gastroesophageal reflux disease (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Pantoprazol

Ingredient

Composition information	Content
Pantoprazol	40mg

Uses

indications

Pantonix 40 drug is indicated in the following cases:

Combined with two appropriate antibiotics to eradicate H.piori in patients with peptic ulcer with the goal of reducing the recurrence of peptic ulcer caused by H.pylori.

Treatment of gastric and duodenal ulcer.

Treatment of medium and severe reflux esophagitis.

Treatment of Zollinger - Ellison syndrome and other cases of other gastric acid secretion.

Pantoprazol is converted into activity in the sub -trailers lying in the cell into the stomach, the enzyme inhibitor H+, K+ - Atpase, is the final stage of producing stomach acid. The inhibition ability of Pantoprazol depends on the dosage and has an impact on both the basic acid excretion as well as when stimulated.

On most patients, symptoms will improve after 2 weeks. As with other H2 receptor inhibitors and inhibitors, the treatment with pantoprazol can cause a decrease in acid in the stomach and thus increase galastin at an acid reduction rate. However, Gastrin increases can be reversed.

Pantoprazol can inhibit independent acid excretion with stimulation by different agents (acetylcholin, histamine, gastrin) and this effect is the same when using pantoprazol in oral or intravenous form.

Dynamic pharmacokinetics

pantoprazol is quickly absorbed after drinking. The half -life is about 1 hour and is 77%. The average plasma disposal time is not correlated with the time to inhibit acid excretion due to the concentrated drug in the cell wall of the stomach. The cohesion rate of Pantoprazol with very high plasma (about 98%) and is transformed through the Cytochrom P450 system.

The ability to accumulate drugs in the body has not been recorded. The metabolites are mainly excreted in urine (80%) and in feces (20%). The main product of the metabolic process is Dimethyl Pantoprazol is a combined sulphate with a half -time time of 1.5 hours.

Before taking Pantonix 40 Incepta Treatment of Gastroesophageal reflux disease (5 blisters x 10 tablets)

How to use

Drink whole tablets must not be broken or chewed.

Dosage

willow amount must be adjusted to suit the clinical condition of each patient.

Combined with two appropriate antibiotics to eradicate H.pylori in patients with stomach and duodenal ulcer.

In patients with peptic ulcer, duodenal positive for H.pylori, to remove the root of pathogens should use regimens combining a variety of drugs. Depending on the type of drug resistance, you can use one of the following regimens:

40 mg Pantoprazol x 2 times/day + 1000 mg amoxicillin x 2 times/day + 500 mg clarithromycin x 2 times/day.

40 mg pantoprazol x 2 times/day + 500 mg metronidazol x 2 times/day + 500 mg clarithromycin x 2 times/day.

40 mg Pantoprazol x 2 times/day + 1000 mg of amoxicillin x 2 times/day + 500 mg of metronidazol x 2 times/day.

In combination therapy, it is recommended to take the second pantoprazol tablet of the second mg before dinner, treatment for 7 days and can last up to two weeks.

With other indications, the dose of 40 mg pantoprazol is as follows:

Treatment of stomach ulcers

Every day a 40 mg pantoprazol. In some cases, the dose may doubled, especially when the patient did not respond to other treatments. Treatment for 4 weeks, if 4 weeks do not cure, continue treatment for 4 more weeks.

Treatment of duodenal ulcer

Every day a 40 mg pantoprazol. In some cases, the dose may doubled, especially when the patient did not respond to other treatments. The duodenal ulcer usually heals within 2 weeks. If 2 weeks do not cure, continue treatment for 2 more weeks.

Treatment of reflux esophagitis

Zollinger - Ellison syndrome and other cases of gastric acid secretion

For long -term treatment, patients should start daily dose treatment of 2 pantoprazol 40 mg. The dose may then be adjusted to increase or decrease as needed by measuring stomach acid secretion. With a dose of over 80 mg/day, divided into twice daily. The temporary dose may be increased to 160 mg but should not be applied for a long time.

unlimited treatment time and need to be adjusted according to clinical needs.

Special subjects

Children under 12 years old

Do not use 40 mg pantoprazol for children under 12 years old.

Patients with severe liver failure

Daily dose is 20 mg of pantoprazole. During treatment, the liver enzyme must be followed, if the liver enzyme increases, it should be discontinued with pantoprazol.

Elderly patients or renal function impairment

Do not reduce the dose in patients with renal impairment (including dialysis patients). The daily dose should not exceed 40 mg of pantoprazol. Except for combination of treatment to kill H.pylori, the dose for elderly patients is still 2 pantoprazol 40 mg per day for a week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? The doses of infusion pantoprazol 378, 230, and 266 mg/kg (38, 46 and 177 times the suggested dose on the person calculated on the area of the skin surface) causing death in the rats, rats and dogs. Acute toxic symptoms such as loss of balance, bend, mouth distortion, deviation, loss of hearing reflexes and shudder.

pantoprazol is not excluded by a separation. In case of overdose, the measures and treatment should be used.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pantonix 40, you may experience unwanted effects (ADR).

Common

Diarrhea, nausea and headache.

Less

Nervous and sensory system: Sleep disorders, dizziness.

Digestive system: abdominal pain, flatulence, constipation, dry mouth, increased liver enzyme, vomiting.

Skin and soft tissue: skin rash, foreign rash, rash.

Systemic: weakness, fatigue, discomfort.

Rare

The immune system: Hypersensitivity (such as hypersensitivity reactions and anaphylactic shock).

Nutrition and metabolic systems: hyperlipidemia and hyperglyceride, cholesterol, weight change.

Nervous and sensory system: depression, disorder, blurred vision.

liver: Increase bilirubin. skin and subcutaneous tissues: urticaria, angioedema.

Muscle system and connective tissue: joint aches, muscle pain.

Reproductive, breast: big breasts in the South.

Common disorders and at the place of use: hyperthermia, peripheral edema.

Very rare

Blood and lymphatic system: thrombocytopenia.

Nervous system: disorientation.

In addition, the following adverse effects may be encountered: hypoglyc sodium, hallucinations, convulsions, liver cell damage, jaundice, liver cell impairment, Stevens Johnson syndrome, Lyell syndrome, diverse pink, sensitive to light, interstitial nephritis.

(For cases where there is no processing, inserting sentences: When encountering side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.)

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Pantonix 40 contraindicated drug in the following cases:

Hypersensitivity to sodium pantoprazol or any ingredients of the drug.

Be cautious when used

When taking the drug for patients with liver function, the concentration of liver enzymes must be carefully monitored.

Patients should be diagnosed with laparoscopic methods before treatment with pantoprazol to eliminate malignant tumors in the stomach and esophagus because the treatment with Pantoprazol can improve symptoms and thus delay the cause of the cause.

Because there is no research on the use of Pantoprazol for children, there is no use of pantoprazol for children.

The ability to drive and operate machinery

There is no relevant report. However, the drug can cause dizziness, blurred, disoriented side effects, so be careful when driving or operating machinery.

Pregnancy

Clinical experience in using Pantoprazole for pregnant women is limited. In animal reproduction studies, the signs of toxicity in the mild fetus are recorded at a dose of over 5 mg/kg. Therefore, do not use pantoprazole for pregnant women.

The period of breastfeeding

It is unknown whether the drug is excreted through breast milk or not, so do not use pantoprazole for breastfeeding or breastfeeding women if required to take the drug.

Drug interaction

pantoprazol is metabolized in the liver through the Cytochrom P450 system. Therefore, drug interactions between Pantoprazol and drugs with the same metabolic path are not excluded. The drugs listed below have been recorded to have negligible interactions with Pantoprazol: Diazepam, Warfarin, Theophylline, Digoxin, Phenytoin, Carbamazepine, Diclofenac, Glibenclamid, Nifedipine and Metoprolol. The use of pantoprazol simultaneously with drugs that depends on the pH as Ketoconazole should be closely monitored.

There is no drug interaction with acid antacids.

Storage

Store in dry, cool, temperature places below 30 ° C. Avoid light.

Other drugs

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