Pantoprazol 40mg Domesco tablets treat stomach ulcers, dozen (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Pantoprazole

Ingredient

Composition information	Content
Pantoprazole	40mg

Uses

Indications

Pantoprazol 40 mg is indicated in the following cases:

Gastric and duodenal ulcer.

Gastroesophageal reflux.

Preventive gastric ulcer, duodenum due to nonsteroidal anti -inflammatory drugs.

Pathological acid secretions such as Zollinger-Elison syndrome. Drugs into acid secretions of the stomach into the stomach to be converted into activated sulfenamids, this form is not as reversible with H+/K+ ATPASE enzyme (also known as proton pump) on the surface of the cell into the stomach wall, inhibiting this enzyme, preventing the final step of the acid secretion into the stomach heart.

So Pantoprazol has the effect of inhibiting the basic acid secretion and even when the stomach is irritated by any stimulating agent. The effect of pantoprazol depends on the dose, the time to inhibit the excretion of gastric acid excretion lasts more than 24 hours, although the semi-exhaust time of Pantoprazol is much shorter (0.7-1.9 hours).

After the oral dose started 40 mg of pantoprazol, gastric acid excretion was inhibited an average of 51% after 2.5 hours. Take Pantoprazol once a day 40mg in 7 days reduces up to 85% of gastric acid excretion. Excreting stomach acid back to normal within 1 week after stopping pantoprazol.

In addition, Pantoprazol can eliminate Helicobacter pylori in the stomach in people with duodenal ulcer and/or esophagitis contaminated with such bacteria. In vitro, pantoprazole reduces the number of H. pylori more than 4 times in PH4.

pharmacokinetics

Pantoprazol absorbs fast, reaching the highest concentration in the blood after drinking about 2-2.5 hours. Pantoprazol absorbs well, less initially metabolized in the liver, oral bioavailability is about 77%. Pantoprazol is strongly attached to plasma proteins (98%), the distribution of adults is 0.17 liters/kg.

Pantoprazol metabolizes mainly in the liver thanks to the cytochrom P450 enzyme system ISOENZYM CYP2C19 to convert it into Desmethylpantoprazol.

A small part is metabolized by CYP3A4, CYP2D6, CYP2C9. In some people, the deficiency of the CYP2C19 enzyme system due to genetics slows down the metabolism of pantoprazol, resulting in a plasma concentration in plasma that may increase by 5 times higher than people with enough enzymes.

The waste sale time of Pantoprazol is 0.7-1.9 hours, prolonged in people with liver failure, cirrhosis (3-6 hours) or slow-metabolic metabolic people (3.5-10 hours). The metabolites excreted mainly through the kidneys (about 80%), 18% through the bile into the feces.

Before taking Pantoprazol 40mg Domesco tablets treat stomach ulcers, dozen (2 blisters x 7 tablets)

How to use

Pantoprazol 40 mg should be taken once a day in the morning, before or after meals. Can be taken with other antacids.

Take the whole tablet, do not break, chew or break the pills. Must fully follow the whole treatment.

Dosage

Gastroesophageal reflux - esophagus

20 - 40 mg, 1 time/day in the morning for 4 weeks, can increase up to 8 weeks when necessary. It is possible to extend the treatment for up to 16 weeks in people with esophagus ulcers after 8 weeks of treatment. Maintain treatment: 20-40mg per day.

benign stomach ulcers

40 mg/day, for 4 to 8 weeks.

duodenum ulcer

40 mg/day, for 2 to 4 weeks.

To eradicate Helicobacter pylori, it is necessary to combine pantoprazol with 2 antibiotics in the treatment mode using 3 drugs in a week according to the regimen: Pantoprazol 40 mg, 2 times a day (morning and evening).

Preventive treatment for gastrointestinal ulcers due to nonsteroidal anti -inflammatory drugs: 20 mg/day.

Zollinger-Elison syndrome (increased pathological secretion)

The starting dose starts 80 mg/day, then adjusts according to the response of the patient (the elderly is a maximum dose of 40 mg/day). The dose can be increased to 240 mg daily. If the daily dose is greater than 80mg, then divided into 2 times a day.

For people with severe liver failure

Must reduce the dose or daily use. The maximum dose per day is 20mg or 2 days of 1 time 40 mg.

For people with kidney failure

usually do not need to adjust the dose.

Children

The safety of pantoprazol in unknown children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Handling

Stomach washing, active carbon, symptomatic treatment and support. Monitor the activity of the heart, blood pressure. If vomiting is prolonged, water and electrolytes must be monitored. Because Pantoprazol is strongly attached to plasma proteins, the method of separation does not eliminate the drug.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using 40 mg pantoprazol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: tired, dizzy, headache

Body: weakness, dizziness, dizziness, insomnia.

Pantoprazol is often well tolerated.

Abdominal pain, diarrhea, headache, fatigue often go away when continuing treatment, very rarely have to stop the drug.

Need to monitor symptoms such as blurred vision, depression, dermatitis ..., bleeding, rash, impotence ...

If prolonged to stop the drug or transfer to other drugs.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pantoprazol 40 mg is contraindicated in cases of hypersensitivity to any component of the drug or other benzimidazol derivatives (such as Esomeprazol, Lansoprazol, Omeprazol, Rabeprazol).

Caution when using

When stopping the drug suddenly, it may cause algs to increase acid secretion.

Before using Pantoprazol, it is necessary to eliminate stomach cancer because the drug can cover symptoms or slow down the diagnosis of cancer.

Be cautious when using pantoprazol in people with acute and chronic liver disease or a history of liver disease. The serum concentration of the drug may increase slightly or mitigate the exhaust, but do not need to adjust the dose.

Must reduce the dose or daily use for patients with severe cirrhosis or liver failure and monitor regular liver function.

Be cautious in people with kidney failure, the elderly.

The ability to drive and operate machines

The drug can cause dizziness and headache. Be cautious when driving and operating machinery.

Pregnancy

There is no adequate study when using Pantoprazol in pregnant women.

Animal studies have shown Pantoprazol through the placenta fence, but have not been observed the effect of teratogenicity. Doses of 15 mg/kg slowed the development of bone in fetus. Only use pantoprazol when really necessary during pregnancy.

Breastfeeding period

whether it is unknown whether pantoprazol is excreted in human milk or not. However, Pantoprazol and its metabolites excrete on mouse milk. Based on the potential of cancer in the mouse of Pantoprazol, it is necessary to consider stopping breastfeeding or stopping the drug, depending on the benefit of Pantoprazol with the mother.

Drug interaction

pantoprazole reduces the absorption of some drugs that have absorption depends on the stomach pH such as ketoconazole, iTraconazole.

pantoprazol is metabolized in the liver thanks to the following cytochrome enzyme but does not inhibit or touch this enzyme activity. However, clinically has not seen significant interactions between Pantoprazol and Diazepam, Digoxin, Nifedipin, Phenytoin, Theophyllin, Warfarin or oral contraceptives.

Severe muscle pain and bone pain may occur when using pantoprazol along with methotrexate.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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