Pantoprazol 40mg khapharco medicine to treat gastroesophageal reflux (100 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Pantoprazol

Ingredient

Composition information	Content
Pantoprazol	40mg

Uses

indicated

pantoprazol indicated treatment in the following cases:

Gastroesophageal reflux. proton. The drug in the acid secretions of the cell into the stomach to be converted into activated sulfenamid, this form is not as reversible with the H+/K+ - ATPase enzyme (also known as the proton pump) on the surface of the cell into the stomach wall, inhibiting this enzyme, preventing the final step of the acid secretion into the stomach heart. So Pantoprazol has the effect of inhibiting the basic acid secretion and even when the stomach is stimulated by any stimulating agent.

The time to inhibit the excretion of gastric acids lasts more than 24 hours, although half -life elimination of Pantoprazol is much shorter (0.7 - 1.9 hours).

pharmacokinetics

Pantoprazole absorbed well, reaching the highest concentration in the blood after drinking about 2-2.5 hours, less initial metabolic in the liver, oral use about 77%.

About 98% of pantoprazol associated with plasma proteins, the volume of distribution in adults is 0.17 liters/kg.

The drug is metabolized mainly in the liver thanks to the cytochrom P450 enzyme system, isenzyme CYP2C19 to convert it into Desmethylpantoprazol, a small amount is also metabolized by CYP3A4, CYP2D6, CYP2C9.

In some people who lack the CYP2C19 enzyme system due to genetics that slow down the conversion of pantoprazol, leading to an increase in drug levels in plasma.

The disposal time of Pantoprazol is 0.7 to 1.9 hours, prolonged in people with liver failure, cirrhosis (3-6 hours or a slow-metabolic metabolic person (3.5 sole 10 hours).

Metabolic substances are excreted mainly through urine (about 80%), 18% through bile and fertilizer.

Before taking Pantoprazol 40mg khapharco medicine to treat gastroesophageal reflux (100 tablets)

How to use

Tablets for oral tablets

Drink whole tablets with water, do not chew.

Dosage

recommended dose: Use once a day in the morning, before or after meals. Antacids can be taken simultaneously with this drug.

Dosage to treat gastroesophageal reflux disease:

Take every day/20 to 40mg every morning for 4 weeks, can last up to 8 weeks if necessary. In 4 to 8 weeks.

Dosage dose of duodenal ulcer: Take once a day 40mg, for 2 to 4 weeks.

Dosage for Helicobacter pylori, need to combine pantoprazol with 2 antibiotics in the treatment mode using 3 drugs in a week according to the content: Pantoprazol 40mg (2 times/day) + Clarithromycin 500mg (2 times/day) + Amoxicilin (2 times/day) or Metronidazol 400mg (2 times/day).

Dosage to prevent gastrointestinal ulcers due to nonsteroidal anti -tablets: Take 1 time 20mg.

Dosage to treat pathological acid secretion in Zollinger - Ellison syndrome: Start taking a dose of 80mg/time, then adjust according to the patient's response, can increase the dose up to 240mg/day. If the daily dose is greater than 80mg, then divided into 2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Heart rate is slightly fast, vasodilation, sleeping, confusion, headache, blurred vision, abdominal pain, nausea and vomiting.

Management:

Stomach washing, active carbon, symptomatic treatment and support. Monitor the activity of the heart, blood pressure. If vomiting is prolonged, water and electrolytes must be monitored. Because Pantoprazol is strongly attached to plasma proteins, the method of separation does not eliminate the drug.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Pantoprazol often has unwanted effects (ADR) such as:

Common, ADR> 1/100:

Body: tired, dizzy, headache.

Skin: skin rash, urticaria.

Body: weakness, dizziness, dizziness, insomnia.

Skin: itching.

Systemic body: sweating, peripheral edema, discomfort, anaphylaxis. Inhibiting, tinnitus, tremor, confusion, hallucinations, abnormalities.

Ion disorders: Hemorrhage reduction.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pantoprazol drug is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Before using pantoprazol as well as other drugs inhibit proton pump for people with stomach ulcers, it is necessary to eliminate stomach cancer because the drug can cover symptoms or slow down the diagnosis of cancer.

Be careful when using pantoprazol in people with liver disease (acute, chronic or history). The serum concentration of the drug may increase slightly and mitigate the excretion; But do not need to adjust the dose. Avoid use when cirrhosis, or severe liver failure. If used, the dose should be reduced or given 1 time a day. Must monitor regular liver function.

Use carefully in people with kidney failure, the elderly.

Using drugs for women during pregnancy and lactation

Pregnancy: There is no adequate studies when using Pantoprazol for pregnant women, so they should be used only when necessary.

Breastfeeding period: The drug can be secreted into breast milk, so it is necessary to consider stopping breastfeeding or stopping the drug, depending on the benefits of Pantoprazol with the mother.

Drug interaction

Although Pantoprazol is metabolized through the cytochrom P450 enzyme system in the liver, but does not inhibit or activate this enzyme activity. There is no clinical interaction that is noticeable about the interaction between pantoprazol and common drugs such as diazepam, phenytoin, nifedipine, theophylin, digoxin, warfarin or oral contraceptive pills.

Like other proton pump inhibitors, Pantoprazol can reduce the absorption of some drugs that their absorption depends on the stomach pH such as ketoconazole, iTraconazole. Severe muscle pain and bone pain can occur when using methotrexat along with pantoprazol.

Medication interactions can affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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