Paracetamol 500mg Mekophar tablets treat mild and medium pain, fever (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

indications

Paracetamol 500mg drug is indicated in the following cases:

Pain relief in cases of mild and medium pain: headache, joint pain, injury pain, back pain, dysmenorrhea, toothache, tooth extraction, ... The properties of phenacetin, have analgesic, reduce fever. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

pharmacokinetics

There is no information.

Before taking Paracetamol 500mg Mekophar tablets treat mild and medium pain, fever (20 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults and children over 12 years:

Take 1-2 tablets/time, 3 times a day. No more than 6 tablets/day.

Children over 6 - 12 years old:

Take 1/2 - 1 tablet/time, 2-4 times a day. No more than 4 tablets/day.

or as directed by the doctor.

The distance between the drug use minimum is 4 hours.

Do not use Paracetamol to treat pain relief for more than 10 days in adults or more than 5 days in children, unless the doctor monitors.

Do not arbitrarily use paracetamol to treat high fever (above 39.5 ° C), fever lasts more than 3 days or recurrent fever unless there is a doctor's monitoring.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Paracetamol overdose may be used by a single dose, or due to a large dose of paracetamol (for example, 7.5 - 10 g per day, for 1-2 days), or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death. Manifestations of paracetamol overdose: Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poisonous dose of the drug.

How to handle

Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of active ingredients sulfhydryl, partially impacted by the addition of glutathion reserves in the liver.

Also can use methionin, activated carbon and/or salt bleaching.

What to do when you forget a dose? However, if near the next dose time, skip the forgotten dose. Do not take double the dose to compensate for the forgotten dose.

Side Effects

When using Paracetamol 500mg Mekophar, you may experience unwanted effects (ADR).

rarely

DA: Ban.

Stomach - intestines: Nausea, vomiting.

Hematology: Dehydration (neutropenia, reducing all bloody, leukopenia), anemia.

Kidney: Kidney disease, kidney toxicity when abused for a long time.

rarely

Skin: Steven - Jonhson syndrome, poisoned epidermal necrotic syndrome, Lyell syndrome, acute pustules syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Paracetamol 500mg Mekophar is contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug (excipients: Talc, Gelatin, Pregelatinized Starch, Magnesi Stearat, Sodium Starch Glycolat, Most denatured starch).

Patients with glucose deficiency - 6 - Phosphate dehydrogenase (G6PD).

Caution when using

paracetamol can cause serious skin reactions such as Steven -Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas acne syndrome (AGEP).

Patients need to stop using paracetamol and see the doctor as soon as they see the rash or other manifestations in the skin or sensitive reactions during treatment. Patients with a history of such reactions should not be used in preparations containing paracetamol.

Be cautious when using paracetamol for people with liver failure, kidney failure, alcoholic, chronic malnutrition or dehydration. Avoid high doses, prolonged use for people with liver failure.

Be cautious when using paracetamol for anemic anemia.

Avoid drinking alcohol when taking the drug.

Paracetamol -containing drugs, not used at the same time with any other drugs containing paracetamol.

The ability to drive and operate machinery

has not seen the drug that affects the ability to drive and operate the machine.

Pregnancy

only use paracetamol when really necessary.

The period of breastfeeding

does not see the unwanted effect on breastfed babies when the mother uses paracetamol.

Drug interaction

Long -term oral high -dose Paracetamol takes slightly anticoagulant effects of COMAARIN and indandion derivatives.

Pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Out of alcohol too much and long may increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) may increase the toxic liver toxicity of paracetamol due to increased drug conversion into toxic substances to the liver.

Simultaneous use of isoniazid with paracetamol may lead to an increased risk of toxicity to the liver, but it has not yet been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions; However, patients must limit their own use of paracetamol while taking anti -convulsions or isoniazid.

Probenecid can reduce paracetamol elimination and increase half -life in the plasma of paracetamol.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C. To be out of reach of children.

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