Paracetamol 500mg Quapharco medicine reduces migraine, colds, flu, sore throat (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol
Indication Sore throat, sinusitis, fever, dysmenorrhea, headache, migraine, body aches, inflammation, toothache
Contraindication Anemia

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

indications

Paracetamol 500 mg drugs are indicated in the following cases:

Symptoms of antipyretic symptoms, mild and medium analgesic in cases: fever, headache, migraine, cold, flu, sore throat, toothache, bone aches, menstrual pain, arthritis pain.

Pharmacokinus

paracetamol (acetaminophen or N - acetyl - P - Aminophenol) is an active metabolic substance of phenacetin, an effective analgesic - antipyretic drug that can replace Aspirin. However, unlike aspirin, paracetamol is not effective for inflammation treatment.

With equal dose calculated by grams, paracetamol has analgesic and antipyretic effect similar to aspirin. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylat, because paracetamol does not work on cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system.

Paracetamol does not work on platelets or bleeding time. When an overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver.

Pharmacokinetics

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. Foods can cause long -lasting release pellets to be partially absorbed and carbohydrate -rich foods reduces the absorption rate of paracetamol. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism and elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); Small amounts of hydroxyl metabolites are found - chemical and reducing acetyl. Children are less likely to glucuro than drugs than adults.

paracetamol is n - hydroxylation by cytochrom p to create N - acetyl - benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dull.

However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In that situation, its reaction to the sulfhydry group of liver protein increases, which can lead to liver necrosis.

Before taking Paracetamol 500mg Quapharco medicine reduces migraine, colds, flu, sore throat (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults and children over 12 years: Take 1-2 tablets at a time, the period of giving medicine every 4 - 6 hours. Take up to 1 g/time, 4 g/24 hours.

Children under 12 years of age: Do not recommend due to the form of preparation and the content of the preparation is not suitable for the dosage of children under 12 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Use N - Acetylcystein oral or intravenously, if there is no N - Acetyl Cysteine can use methin methin to use activated carbon or salt bleach, they reduce the absorption of paracetamol.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Paracetamol 500mg Quapharco, you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. In a few individual cases, paracetamol has caused neutropenia, thrombocytopenia and all bloody hemoglobin.

Uncommon, 1/1000

Ban, nausea, vomiting, hematopoietic disorders, anemia, kidney disease, toxicity on the kidneys when abuse for many days.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Paracetamol 500mg quapharco drug contraindicated in the following cases:

Patients with anemia many times or heart, lung, kidney, or liver disease.

Patients with paracetamol too hypersensitivity.

Patients with G6PD deficiency (Glucose - 6 - Phosphate dehydrogenase).

Be cautious when using

People with severe kidney failure, people with anemia.

Avoid or limit drinking alcohol when using the drug.

The ability to drive and operate machinery

does not affect.

Pregnancy

should only use paracetamol in pregnant people when really necessary.

The period of breastfeeding

does not see the unwanted effect in breastfed children when the mother uses paracetamol. However, only paracetamol should be used in breastfeeding women when really necessary.

Drug interactions

Long -term oral drinks that slightly increase the anticoagulant effect of Coumarin and derive indandion.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Occurs a lot of alcohol, taking anti -convulsions (phenytoin, barbiturat, carbamazepin), izoniazid increases the risk of paracetamol toxic to the liver.

Storage

In a dry place, avoiding light, the temperature does not exceed 30 ° C.

Other drugs

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