Paracetamol 500mg the fever, headache reduction (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

indications

Paracetamol 500mg drug is indicated in the following cases:

Antipator of fever due to the causes. Aspirin. However, unlike aspirin, paracetamol is not effective in treating inflammation. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to aspirin.

paracetamol reduces the body temperature when the fever, but rarely reduces the body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

Paracetamol at the dose of treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate (because paracetamol does not work on the whole body cyclooxygenase, only affect cycloxygenase/prostaglandin of central nervous system). Paracetamol does not work on platelets or bleeding time.

Pharmacokinetics

absorption

Paracetamol is absorbed quickly and almost entirely through the gastrointestinal tract. Foods can slow down partial absorption and carbohydrate -rich foods reduces the absorption rate of paracetamol. The peak concentration of the drug in plasma is achieved within 30 - 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism

Paracetamol is N - hydroxylation by cytochrome P450 to form N - Acetyl - Benzoquinonimin, an intermediary with high reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dull.

However, if you take high doses of paracetamol, this metabolite is formed in sufficient amount to exhaust the glutathion of the liver, leading to its reaction to the sulfhydryl group of the liver protein, causing liver necrosis.

Elimination

Paracetamol's plasma sale time is 1.25 - 3 hours, which can last for toxic doses or in patients with liver lesions.

Before taking Paracetamol 500mg the fever, headache reduction (20 blisters x 10 tablets)

How to use

oral medication.

Dosage

only for adults and children> 11 years old, younger children should use lower content.

Analgesic or antipyretic for adults and children over 11 years old: 1-2 capsules/time x 2-3 times/day. Each time drink 4 - 6 hours apart and do not use more than 4 g (8 tablets)/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Paracetamol poisoning 500mg may be due to a single -dose, due to the repeated repeated doses of paracetamol (7.5 - 10 g/day, for 1-2 days) or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Nausea, vomiting, abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Blood methemoglobin leads to purple blue, mucous and nails is a sign of acute poisoning P - aminophenol substance; A small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking Paracetamol 500mg.

When severe poisoning, it can initially irritate the central nervous system, agitation, and delusion. Next can inhibit the central nervous system, stunned, lower body temperature, tired, fast and shallow breathing; Fast circuit, weak, irregular, low blood pressure, circulatory failure.

Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The deadly convulsions may appear. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage becomes clearly within 2-4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and plasma bilirubin levels may also increase. Moreover, when the liver lesions spread, the long prothrombin time. Patients with untreated poisoning have serious liver damage, 10-20% of them eventually die from liver failure.

Acute renal failure also occurs in some patients. The liver biopsy detects the central necrosis of the lobe except the area around the door vein. In cases of non -death, liver lesions recover after weeks or months.

Handling

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver.

n - acetylcysteine works when taken or intravenously. Use immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when used for less than 10 hours after taking paracetamol. Dilute N - Acetylcystein solution with water or non -alcoholic beverages to get a 5% solution and drink for 1 hour after mixing. Use N - Acetylcystein with the first dose of 140 mg/kg, then take 17 more dose, each dose of 70 mg/kg each 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N - Acetylcystein includes skin rash, urticaria (no need to stop the drug), nausea, vomiting, diarrhea, anaphylactic reaction.

If there is no N - acetylcystein, methionine can be used. In addition, activated carbon can be used to reduce paracetamol absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Paracetamol 500mg Thephaco, you may experience unwanted effects (ADR).

Uncommon, 1/1000

DA: Ban.

Digestive: Nausea, vomiting.

Hematology: Dehydration (neutropenia, all bloody, leukopenia), anemia.

Kidney: Kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

PPARACETAMOMOMOMOMOMOM 500mg Thephaco contraindicated in the following cases:

Patients with anemia many times or heart, lung, kidney or liver disease.

Patients with paracetamol too hypersensitivity.

Patients with glucose deficiency - 6 - phosphate dehydrogenase.

Be cautious when using

Precautions in patients with anemia before.

Should limit alcohol due to drinking alcohol can cause toxicity to the liver of paracetamol.

When using high doses must be closely monitored. Do not overdose to be prescribed.

Caution for people with impaired liver or kidney function.

Doctors need to warn patients on signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had serious skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may have for fetal development. Therefore, only Paracetamol should only be used in pregnant people when really necessary.

Breastfeeding period

can be used in breastfeeding women.

Drug interaction

long -term and high -dose Paracetamol oral doses increases the anticoagulant effects of COUMARIN and derivatives.

Paracetamol causes serious antipyretic in patients with simultaneously phenothiazine and cooling therapy.

Out of alcohol too much and long day increases the risk of paracetamol toxic to the liver.

Anti -convulsions (Phenytoin, Barbiturat, Carbamazepin), Isoniazid increases the toxicity of Paracetamol.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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