Paracetamol Choay 500mg Sanofi tablets treat mild to medium pain symptoms, fever (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, sinusitis, fever, cold, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

indications

Treatment of mild to medium pain symptoms and/or fever.

Pharmacokinus

Paracetamol is an effective analgesic - antipyretic. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

Paracetamol does not have the effect of inflammation treatment.

With the dose of treatment, paracetamol metabolizes mainly through a suifat and glucuronid complex reaction. A small amount usually converts into a toxic metabolite, N-acetyl-P-Benzoquinonimin (NAPQI). Napqi is detoxified by glutathion and eliminated into urine and/ or bile. When the metabolic is not connected to the glutathion, it is toxic to liver cells and cell necrosis. Paracetamol is often safe when used for treatment, because the amount of Napqi is formed relatively low and glutathion formed in liver cells that are sufficiently associated with NAPQI. However, when overdose or sometimes with the common doses used in some sensitive people (such as malnutrition, drug interaction, alcoholism, genetics), Napqi concentration can be accumulated toxic in the liver.

Dynamic pharmacokinetics

absorption: Paracetamol when taken or taken will be absorbed quickly and completely. The peak concentration of plasma is about 10-60 minutes after drinking.

Distribution: fast and uniform in most body tissues, about 25% paracetamol in the blood combined with plasma proteins.

Metabolism: Paracetamol is metabolized mainly in the liver in two main paths in the liver: in conjunction with glucuronic acid and associated with sulfuric acid; Combined with sulfuric acid quickly saturated when taking a higher dose but still within the scope of treatment. The saturation of the glucoronid process appears only when the dose is higher, toxic to the liver. A small part (less than 4%) is trips by Cytochrom P450 to form a high reaction intermediate (N-acetyl Benzoquinoneimin), under normal usage, this intermediate will be detoxified by glutathion reduction and is eliminated in urine after conjugated with cysteine and mercapturic acid. However, when poisoning with high doses of paracetamol, the amount of metabolites has this toxicity increases.

Elimination: Paracetamol metabolites are mainly excreted in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate conjugate (about 30%). Under 5% is eliminated in constant form. Selling time for plasma is about 2 hours.

Before taking Paracetamol Choay 500mg Sanofi tablets treat mild to medium pain symptoms, fever (10 blisters x 10 tablets)

How to use

Take oral use. Should drink during or after meals.

Number of drugs: Taking medicine according to a regular schedule can avoid the oscillation of pain or fever.

The time between two taken medicine:

Children must be given regular medication, including at night, and preferably 6 hours apart, or at least 4 hours.

Adults and children weighing over 50kg (ie about 15 years of age):

The usual dose is one to two tablets 500mg oral at each time, if necessary, it can be repeated after at least 4 hours.

In general, it is not necessary to use more than 3G Paracetamol (ie 6 tablets) per day. However, in the case of severe pain, and according to the doctor's advice, the total dose may increase to 4G Paracetamol (ie 8 tablets) per day.

However:

Paracetamol dose is higher than 3 g/day need a doctor's opinion. The minimum distance between two drinks is 4 hours.

in children:

Paracetamol dose depends on the child's weight; Age for reference only; And need to use more appropriate drugs.

Paracetamol's daily recommended dose is about 60 mg/kg/day, oral division in 4 or 6 times, or about 15 mg/kg every 6 hours or 10 mg/kg every 4 hours.

For children weighing from 27 to 40 kg (about 8 to 13 years old):

Dosage is each time taking a 500mg tablet, if necessary, it can be repeated every 6 hours, but not more than 4 capsules per day.

For children weighing from 41 to 50 kg: (about 12 to 15 years old):

The dose is each time taking a 500mg tablet, if necessary, it can be repeated every 4 hours, but not more than 6 capsules per day.

In case of kidney failure

When severe renal failure (creatinine clearance below 10 ml/minute), the distance between two medications must be 8 hours, and at least 4 hours. Paracetamol dose cannot exceed 3G (ie 6 tablets) per day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Overdose of 10g (150 mg/kg of weight in children) can cancel liver cells, which can lead to absolutely non -recovery necrosis, with manifestation of liver function, brain disease can lead to coma and death. Transaminase in the liver increases, increased bilirubin, decreasing prothrombin.

Emergency treatment: In the hospital:

Bowel washing and drinking activated carbon.

Use n-acetylcystein, paracetamol antidote, intravenously or drink if possible before the 10th hour. In addition, activated carbon can be used, or salted, they have the ability to reduce the absorption of paracetamol

help breathing. However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

few side effects, but if there are side effects:

Less:

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs. In a few specific cases, Paracetamol has caused neutropenia, thrombocytopenia and all bloody hematuria.

Rare: Stevens-Johnson syndrome, Lyell syndrome, poisoning epidermal necrosis, acute pustules rash, hypersensitivity reaction.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Paracetamol drugs are contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

If the pain lasts more than 5 days or the fever lasts more than 3 days, or if the drug is not effective or any other symptoms occur, do not continue treatment without consulting the doctor.

Be careful in patients with anemia before, impaired liver and kidney function. Overdose or long -term treatment can cause liver necrosis, kidney failure.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

For Paracetamol-containing drugs: Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

The ability to drive and operate machinery

The drug does not cause dizziness, drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

only use drugs for pregnant women when really necessary.

breastfeeding period

must be very cautious when taking medicine for nursing women.

Drug interaction

Long -term oral high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

It is necessary to pay attention to the possibility of serious heat lowering the patient and phenothiazine and cooling (such as paracetamol).

Anti -seizure drugs (Phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxic of paracetamol.

Probenecid may reduce paracetamol elimination and increase the half -life of plasma of paracetamol.

Isoniazid and anti -tuberculosis drugs increase the toxicity of paracetamol for the liver.

metoclopramid, domperidon increases the absorption speed of paracetamol, cholestyramin reduces the absorption rate of paracetamol.

Out and long -term drinking increases the toxicity on the liver of paracetamol.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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