Paracetamol Stada 500mg tablets treat headaches, nerve pain, toothache (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	500mg

Uses

What is the effect

Paracetamol? Paracetamol 500mg is indicated for treatment in the following cases:

Mild to medium pain including headache, migraine, nerve pain, sore throat, menstrual pain, pain.

Mechanism of action

Pain relief

Paracetamol pain relief mechanism has not been fully determined.

Paracetamol can operate mainly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and at a lower level, through peripheral effects by preventing painful impulses.

Peripheral effects may also be due to prostaglandin synthesis or synthetic inhibition or the activity of other substances that cause receptor sensitivity to mechanical or chemical stimulation

A reduction of fever

Paracetamol has an antipyretic effect by focusing on the hypothalamic air conditioning center to create peripheral vasodilation leading to increased blood flow through the skin, sweating and cooling.

The central effects are probably related to the inhibition of prostaglandin synthesis in the hypothalamus.

Dynamic pharmacokinetics

Paracetamol is easily absorbed from the digestive tract with peak concentration in plasma reaching about 30 minutes to 2 hours after drinking. Paracetamol is metabolized in the liver and excreted in urine mainly in the form of glucuronide and sulfate.

less than 5% is excreted in a constant form. The selling time varies from 1 to 4 hours. Links to negligible plasma proteins at conventional therapeutic concentrations but increases when increasing concentration.

The secondary hydroxylation metabolic is usually produced in very small amounts by the oxidase of the mixed function in the liver, and is often detoxified by concluding with the liver glutathione that can be accumulated after overdose of paracetamol and liver damage.

Before taking Paracetamol Stada 500mg tablets treat headaches, nerve pain, toothache (10 blisters x 10 tablets)

How to use

Paracetamol 500mg Stada oral.

Dosage

Adults, elderly and adolescents 16 years and older 2 tablets every 4 hours, up to 8 tablets in 24.

Children 6 - 9 years old: 1/2 tablets every 4 hours, up to 4 doses in 24 hours.

Children 10 - 11 years old: 1 tablet every 4 hours, maximum 4 hours in 24 hours.

Youth 12 - 15 years old: 1 to 1.5 tablets every 4 hours, up to 4 doses in 24 hours.

Do not use this medicine for children under 6 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Oral dose ≥ 5g paracetamol can lead to liver damage if the patient has one or more risk factors below:

Patients who are under long -term treatment with carbamazepine phenobarbitone, phenytoin, primidone, rifampicin, st John's wort or other drugs that cause liver enzymes

Patients often use alcohol (ethanol) beyond the recommended amount. Cystic fibrosis, HIV infection, lack of food, weakness.

Symptoms of paracetamol overdose in the first 24 hours are pale, nausea, vomiting, anorexia and abdominal pain.

Liver damage can become clear from 12 to 48 hours after drinking. Extraordinary metabolism of glucose and metabolic acidosis may occur.

In severe poisoning, liver failure can progress into brain disease, hemorrhage, hypoglycemia, brain edema and death.

Acute renal failure with acute renal necrosis, clearly manifested by lumbar pain, blood urination and proteinuria, can grow even when there is no serious liver damage. Cardiac arrhythmia and pancreatitis have been reported.

Treatment for paracetamol overdose:

Immediately treatment is essential in the treatment of paracetamol overdose. Despite the lack of significant early symptoms, patients should be transferred to the emergency hospital for immediate medical care.

Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of internal organs. The treatment must be consistent with the established instructions.

Treatment with activated carbon can be considered to use if taken overdose within 1 hour. Paracetamol concentration in plasma should be measured at 4 hours or later after oral (concentration measured earlier than unreliable).

Acetylcystein treatment can be used up to 24 hours after taking paracetamol, however, the maximum protection effect achieved within 8 hours after drinking.

If necessary, the patient may be intravenous N - Acetylcystein intravenously, with the set regimen. If vomiting does not affect, oral methionine can be an appropriate alternative for remote areas, outside the hospital.

Treatment of patients with serious liver dysfunction after 24 hours of overdose should be discussed with liver specialist.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects (ADR) when using Paracetamol 500mg Stada that you may encounter:

rarely encountered the adverse effects of paracetamol. Very rare cases of serious skin reactions are reported.

There have been reports on sample disorders including plateletal hemorrhage, methemoglobin blood and grain leukemia, but not sure the cause related to paracetamol.

When experiencing side effects of the drug, patients need to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Paracetamol 500mg stada drugs contraindicated in the following cases:

Hypersensitivity to paracetamol or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Warning patients on signs of serious skin reactions such as Stevens - Johnson syndrome (SJS) poisoned epidermal necrotic syndrome (Ten) or Lyell syndrome, provincial -level pustular syndrome (AGEP).

Be careful when using paracetamol for patients with severe renal impairment or severe liver failure. The risk of overdose is higher in people with alcoholic liver disease.

Women during pregnancy and lactation

pregnancy:

Epidemiological studies in pregnancy in humans have shown that there is no adverse effect due to the use of paracetamol in the recommended dosage, but patients should use this drug as advised by the doctor.

Breastfeeding period:

Paracetamol is excreted through breast milk but does not mean clinically significant. The data is announced without contraindications for breastfeeding women.

Follow the instructions from the doctor. The drug should only be used when the benefits are out of risks.

The ability to drive and operate machinery

Follow the instructions from the doctor.

Drug interaction

cholestyramine

Paracetamol's absorption speed is reduced by cholestyramine. Therefore, Cholestyramine should not be used within an hour when using paracetamol if you want to reduce pain effect of paracetamol is maximum

metoclopramide domperidone

The absorption of paracetamol is increased by metoclopramide and domperidone. However, it is not necessary to avoid simultaneous use.

warfarin

Warfarin's anticoagulant and other coumarin effects can be enhanced when using Paracetamol regularly, causing higher risk of bleeding; Non -constant dose has no significant effect.

chloramphenicol

Simultaneous use of paracetamol causes increased plasma concentrations of chloramphenicol.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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