Paralmax 500mg Boston tablets treat mild to medium pain, headache, toothache (10 blisters x 12 tablets)

is the active metabolite of phenacetin, an effective antipyretic analgesic that can replace aspirin but have no anti -inflammatory effect. Paracetamol acts on the hypothalamus causing cooling, increasing heat due to vasodilation, increasing peripheral blood flow.

Paracetamol only affects the cyclooxygenase/prostaglandin of the central nervous system does not work on the systemic cyclooxygenase, so it has little impact on the cardiovascular and respiratory system, does not change the balance of acid-base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate. No platelet effect or bleeding time.

pharmacokinetic

paracetamol

is absorbed quickly and completely through the gastrointestinal tract, especially carbohydrate -rich foods that reduce the absorption of paracetamol. The peak concentration is within 30 to 60 minutes after the dose of treatment.

Quick and uniform distribution in most tissues. About 25% associated with plasma proteins. Selling duration of plasma from 1.25 to 3 hours (longer if the toxic dose is used or liver damage).

Elimination through glucuronic acid -like urine, sulfuric acid, cysteine, hydroxylation and reduction.

Paracetamol is converted into n-acetyl-benzoquinoimin, capable of causing liver necrosis.

What to do when overdose?

Symptoms

Initially: stimulating the central nervous system, agitated and delirious; Then: Inhibit the central nervous system, stunned, lower body temperature, tired, rapid and shallow, fast, weak, uneven pulse, low blood pressure, circulatory failure, reduced blood oxygen leading to vascular collapse.

Clinically

clinically sees liver damage that is enamel aminotransferase plasma increased or very high.

Management

When Paracetamol poisoning should be treated positively, gastric lavage in any situation, preferably within 4 hours after taking the drug. Give sulfhydryl compounds like N-acetyl Cystein immediately within 36 hours after taking paracetamol. In addition, methionine, activated carbon and/or salt bleach.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Precautions when used

should not be used with other fever -reducing drugs containing paracetamol.

Patients with alcoholism, patients with impaired renal function.

Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SIS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Use drugs for women during pregnancy and lactation

should only be used for pregnant women when really necessary, not seeing unwanted effects in breastfeeding children when mothers use drugs. The drug is secreted in breast milk in very small amounts.

The effect of the drug on driving and operating machinery

has no significant effect when using the drug.

Medicinal interaction

Anticoagulant drugs: Paracetamol long -dose long -dose taken to slightly increase the anticoagulant effect of COUMARIN and derive indandion.

Phenothiazon needs to pay attention to the possibility of serious heat lowering in patients using phenothiazon.

Alcohol: Excessive and long drinking can increase the risk of Paracetamol's liver toxicity.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, can increase the liver toxicity of paracetamol.

Isoniazid: simultaneously using isoniazid with paracetamol can also lead to an increased risk of toxicity to the liver.

metoclopramid and domperidon: can make paracetamol increase the absorption rate of paracetamol.

cholestiramin: reduces the absorption capacity of paracetamol.