Pargine oral solution 1000mg/10ml CPC1 HANOI treatment hyper Ammonia blood (4 blisters x 5 tubes x 10ml)

Dosage form Oral solution
Specifications Box of 4 blisters x 5 tubes x 20ml
Ingredient Arginin hydrochlorid

Ingredient

Thành phần cho 10ml

Composition information	Content
Arginin hydrochlorid	1000mg

Uses

indications

Pargine drugs are indicated in the following cases:

Maintain treatment for patients with hyper ammonia in patients with carbamylphosphate synthetase deficiency, deficiency of ornithin carbamyl tranferase. Treatment support indigestion disorders. ArgininoSuccinat Synthetase (ASS), or ArgininoSuccinat Lyase (ASL). Use Arginin hydrochloride for disorder patients as above to restore arginine levels in the blood to help prevent protein catabolism. Arginin enhances the liver detoxification function, provides arginine to the urea cycle, reduces the concentration of ammonia in the blood, increases glutathion, thus increasing the metabolism of toxins for the liver such as pharmaceuticals, toxic factors from the environment, tobacco, alcohol ...

Arginin effectively protects liver cells, especially cell membranes, significantly reduces serum got levels (SGOT), mitochondrial got (Mgot) and SGPT. Has the effect of protecting the mitochondrial membrane, thereby preventing Mgot release.

arginin restores the function of the mitochondria, maintains energy for physiological activity, improves cell metabolism; Increase glucid metabolism, lipid, protid, increase coenzyme a.

Dynamic pharmacokinetics

arginin hydrochloride absorbed well through the digestive tract, the peak concentration in plasma is achieved after drinking about 2 hours. Arginin hydrochloride closely combines with many biochemical paths. Amino acids are metabolized through the liver to form ornithin and urea by hydrating Guanindin under the catalyst of Arginase. Arginin is filtered in glomerular and reabsorbed almost completely in the renal tubules.

Before taking Pargine oral solution 1000mg/10ml CPC1 HANOI treatment hyper Ammonia blood (4 blisters x 5 tubes x 10ml)

How to use

Pargine is used orally. Break the plastic tube and directly drink the solution in the tube. Can dilute with water, or drink water after taking the medicine.

Should be taken before the main meals or as soon as there are symptoms.

Dosage

Hyper ammonia maintenance treatment in patients with carbamylphosphate synthetase, ornithinin carbamyl transferase:

Babies: 100 mg/kg per day, divided 3-4 times.

Children from 1 month to 18 years old: 100 mg/kg per day, divided 3-4 times.

Maintain treatment for patients with hyper -hypercemolity of blood citrulin, arguoSuccinicuria:

infant: 100 - 175 mg/kg/time; Use 3-4 times daily with food, adjust the dose according to the response.

Children from 1 month to 18 years old: 100 - 175 mg/kg/time; Use 3-4 times daily, with food, adjust the dose according to the response.

Treatment support indigestion disorders:

Adults: Take 3 - 6 g/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Overdose in children can lead to metabolic chlorine, brain edema or may die. Should determine the degree of shortage and calculate the amount of alkaliogens use.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Pargine, you may experience unwanted effects (ADR).

Pain and abdominal distention, thrombocytopenia, hypernujiang heads, sickle cell anemia, bun, creatinin and serum creatin.

Allergic reactions with manifestations such as red rash, swelling of hands and face, these symptoms will reduce quickly when stopping the drug and using diphenhydramin.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Pargine drugs contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with allergies.

Patients with Urian cycle disorders accompanied by an arginase enzyme deficiency.

Be cautious when using

Pay attention to the sugar content of the drug (3 g in every 10 ml) when used for patients with diabetes or sugar -diet patients.

Should stop the drug if diarrhea occurs.

Arginin may change the ratio between extracellular and intracellular, plasma potassium levels can increase when taking arginine in patients with renal impairment. Should be cautious when using Arginin for patients with kidney disease or urinating.

When using high doses of arginin to treat acute blood ammonia infection can cause metabolic acidic contamination due to hypertension in chlorine, therefore, plasma chlorine and bicarbonate levels should be monitored and at the same time supplementing the corresponding amount of bicarbonate.

Arginin contains a high level of metabolic nitrogen, so it should be assessed to temporarily impact the high amount of nitrogen on the kidneys before starting treatment with arginine.

Arginin does not have the effect of treating hyperactive hyperactive hyperactememalemia caused by organic acid disorders, and should not be used in the case of above disorders.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

has no adequate and controlled experience in pregnant women, should not take the drug during pregnancy.

breastfeeding period

amino acids are excreted into breast milk in very small amounts that can not be harmful to children. However, caution should be cautious when taking medicine in nursing women.

Interactive drug

Take medications for oral diabetes for oral route for a long time that can inhibit plasma glucagon response to arginine. When patients intolerant to glucose are used glucose, phenytoin reduces the response of insulin in plasma with arginine. Hyperbonia can occur when using arginine to treat metabolic acidosis for patients with new liver disease recently using Spironolacton.

Storage

In closed packaging, avoid moisture, avoid light, temperature below 30 ° C.

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