Partamol 325 Stella medicine reduces mild and medium pain (200 tablets)

Dosage form Tablet
Specifications Bottle of 200 tablets
Ingredient Paracetamol
Indication Fever, colds, headache, body aches, teething
Contraindication Liver failure

Ingredient

Composition information	Content
Paracetamol	325mg

Uses

indications

Partamol 325 drugs are indicated/used in the following cases:

Used in mild to medium pain and fever, especially for patients with contraindications or non -tolerance of salicylate. The drug has a good impact on mild pain that is not in the origin of the organs. Paracetamol relieves pain and reduces fever according to the same mechanism as salicylat. At the same dose, paracetamol for pain relief and fever reducing the same as aspirin.

paracetamol reduces body temperature in fever but rarely reduces body temperature in normal people. Paracetamol is a weak, reversible, non -special inhibitor on cyclooxygenase at 1 g/day. Paracetamol's treatment dose has negligible effects on the cardiovascular and respiratory system, however, the toxic dose can cause circulation and rapid breathing.

Pharmacokinetics

absorption

Paracetamol is easily absorbed through the gastrointestinal tract with peak plasma concentrations from 10 - 60 minutes after drinking.

Distribution

paracetamol is distributed in most body tissues. The drug is given the placenta and is present in breast milk. The cohesion of the drug to the plasma proteins is negligible at conventional treatment concentrations but increases when the drug concentration increases. Selling time is about 1-3 hours.

Metabolism

paracetamol metabolizes most through the liver and excreted in urine mainly in the form of associated with glucuronic and sulfate. Under 5% of drugs are eliminated in a constant form. The secondary metabolic substance caused by hydroxylation (nacetyl-p-benzoquinoneimin) is usually generated in very small amounts in the liver and kidneys. This substance is detoxified by a combination with glutathion but can accumulate after paracetamol overdose and damage tissue.

Elimination

No report.

Before taking Partamol 325 Stella medicine reduces mild and medium pain (200 tablets)

How to use

partamol 325 is taken orally.

Dosage

Pain relief or fever for adults and children over 11 years old

325 - 650 mg, every 4 - 6 hours when necessary, no more than 4 g a day; Larger doses (eg 1 g/time) can be used to relieve pain in some patients.

Do not arbitrarily use paracetamol to reduce pain for more than 10 days for adults and 5 days for children.

Do not arbitrarily use paracetamol to reduce fever in cases of too high fever (over 39.5oC), fever lasts more than 3 days or recurrent fever.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Hepatic necrosis depends on the dose is the most dangerous toxicity of paracetamol poisoning and can be fatal.

Treatment:

When paracetamol poisoning, acetylcysteine is used as a detox. Using acetylcysteine by oral, the starting dose is 140 mg/kg; Next is the maintenance dose of 70 mg/kg every 4 hours x 17 doses. Within 1 hour after the starting dose or the maintenance dose of acetylcysteine, if the patient has vomiting, the dose should be repeated. If the patient still cannot drink, Acetylcystein can be taken through the catheter into the duodenum. It is also possible to use vomiting medication for patients who often vomit. If the poisoning has just occurred, using activated carbon can reduce the absorption of paracetamol and should be treated as soon as possible (preferably within 1 hour after being poisoned). Other stomach detoxification methods (such as IPECA syrup) are less effective and often not recommended.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

No report.

Uncommon, 1/1000

DA: Ban.

digestion: Nausea, vomiting. blood: Hematopoiia (neutropenia, hypoglycemia, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Partamol 325 drug contraindicated in the following cases:

Patients with anemia or heart, lung, kidney or liver disease.

Patients with alcoholism.

Patient hypersensitivity to paracetamol or other ingredients of the drug.

Patients with glucose enamel deficiency - 6 - phosphate dehydrogenase.

Caution when using

paracetamol is relatively non -toxic at the dose of treatment. Sometimes there are skin reactions including rugged rash and urticaria; Other sensitive reactions include larynx edema, angioedema and anaphylactic reactions that may rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of p-aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

People with phenylceton - urinary (meaning, gene deficiency determines the status of phenylalanin hydroxylase) and the person who must limit the amount of phenylalanin put into the body must be warned that some paracetamol preparations contain Aspartam and will metabolize in the stomach - the intestinal citadel of phenylalanin after drinking.

Some forms of paracetamol drugs on the market containing sulfit can cause allergic reactions, including anaphylaxis and life -threatening or less weight -threatening attacks in some hypersensitivity people.

Must use paracetamol carefully in patients with anemia before, because heart green may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

drinking plenty of alcohol can increase the toxicity to the liver of paracetamol; Should avoid or limit drinking.

Use carefully with people with impaired liver or kidney function.

Doctors need to warn the patient about signs of serious skin reactions such as Stevens-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

no.

Pregnancy

paracetamol is a painkiller commonly used for pregnant women. However, the use of paracetamol at the end of pregnancy is related to the persistent wheezing problem of babies. Do not use paracetamol too often for pregnant women.

The period of breastfeeding

has not seen the side effects occurring on breastfed babies when the mother is using paracetamol, the amount of paracetamol is distributed into breast milk very little so it cannot be harmful to breastfeeding.

Drug interaction

Long -term oral high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Out of alcohol too much and long may increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions; However, patients must restrict self -use of paracetamol while taking anti -convulsions or isoniazid.

Storage

In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.

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