Partamol 500 Stella medicine to treat pain and fever from mild to medium (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, sinusitis, fever, dysmenorrhea, cold, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

Indications

Partamol 500 drugs are indicated in pain and mild to medium pain and fever, especially for patients with contraindications or non -tolerance of salicylate intolerance. The drug has good effect on mild pain not in the origin of the organs.

Pharmacokological

Paracetamol is a non-addictive summary derivative of p-aminophenol. Paracetamol relieves pain and reduces fever according to the same mechanism as salicylate.

In the same dose, paracetamol has analgesic and fever -reducing effect similar to Aspirin.

paracetamol reduces body temperature in fever but rarely reduces body temperature in normal people.

paracetamol is a weak, reversible, non -special inhibitor on cyclooxygenase at 1 g/day.

Paracetamol's treatment dose has negligible effects on the cardiovascular and respiratory system. However, toxic doses can cause circulation and rapid breathing.

pharmacokinetic

absorption

Paracetamol is easily absorbed through the gastrointestinal tract with peak plasma concentrations 10 - 60 minutes after drinking.

Distribution

paracetamol is distributed in most body tissues. The drug is given the placenta and is present in breast milk. The cohesion of drugs with plasma proteins is negligible at conventional treatment concentrations but increases when the drug concentration increases.

Metabolism - Elimination

paracetamol metabolizes most through the liver and excreted through urine mainly in the form of associated with glucuronide and sulfate. Under 5% of the drug is eliminated in a constant form.

Paracetamol waste sale time changes about 1-3 hours.

The secondary metabolic substance caused by hydroxylation (n-acetyl-p-benzoquinoneimine) is usually generated in very small amounts in the liver and kidneys. This substance is detoxified by a combination with glutathione but is accumulated after paracetamol overdose and tissue damage.

Before taking Partamol 500 Stella medicine to treat pain and fever from mild to medium (10 blisters x 10 tablets)

How to use

Partamol 500 tablets for oral tablets.

Dosage

Adults and children over 12 years: 500 - 1000 mg every 4 - 6 hours when necessary but not more than 4 g/day.

Children 6 - 12 years old: 250 - 500 mg every 4-6 hours when needed, up to 4 times/day.

Do not arbitrarily use paracetamol to reduce pain for more than 10 days for adults and 5 days for children.

Do not arbitrarily use paracetamol to reduce fever in cases of too high fever (over 39.5ºC), fever lasts more than 3 days or recurrent fever.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Using Acetylcysteine by oral, the starting dose is 140 mg/kg, followed by a maintenance dose of 70 mg/kg after every 4 hours x 17 doses.
Within 1 hour after the starting dose or the dose of acetylcysteine maintenance, if the patient has vomiting, the dose should be repeated. If the patient still cannot drink, Acetylcysteine can be taken through the catheter into the duodenum. Anti -vomiting may be used for patients who often vomit.
If the poison has just occurred, using activated carbon can reduce the absorption of paracetamol and should be treated as soon as possible (preferably within 1 hour after poisoning).
Other stomach detoxification methods (such as IPECA syrup) are less effective and often not recommended.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Partamol 500, you may experience unwanted effects (ADR).

Uncommon, 1/1000

DA: Ban.

digestive: nausea, vomiting. blood: Hemorrhagic disorders (neutropenia, hypoglycemia, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, 1/10000

Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Partamol 500 drugs contraindicated in the following cases:

Patients with many anemia or heart, lung, kidney or liver disease.

Patients with alcoholism.

Patient hypersensitivity to paracetamol.

Patients with glucose-6-phosphate dehydrogenase.

Caution when using

Paracetamol is relatively non -toxic at the dose of treatment. Sometimes there are skin reactions including rugged rash and urticaria, other sensitive reactions including laryngeal edema, angioedema and anaphylactic reaction that can rarely occur.

Plateletal reduction, leukopenia and all bloody hemoglobin have occurred with the use of p-aminophenol derivatives, especially when using large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

People with phenylceton - iron (gene deficiency determine the status of phenylalanine hydroxylase) and people must limit the amount of phenylalanine put into the body must be warned of some paracetamol preparations containing aspartame, which will metabolize in the stomach - phenylalanine citadel after drinking.

Some forms of paracetamol drugs on the market containing sulfite can cause allergic reactions, including anaphylaxis and life -threatening or less serious hypersensitivity.

Must use paracetamol cautious in anemia patients because purple blue may not be clear, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can increase the toxicity of Paracetamol's liver. Should avoid or limit drinking.

Use carefully with people with impaired liver or kidney function.

Doctors need to warn the patient about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

paracetamol is a painkiller commonly chosen for pregnant women. However, the use of paracetamol at the end of pregnancy is related to the persistent wheezing problem of babies. Do not use paracetamol too often for pregnant women.

Breastfeeding period

Not seen unwanted effect on breastfed babies when the mother is using paracetamol, the amount of paracetamol is distributed into breast milk very little so it cannot be harmful to breastfeeding.

Medicinal interaction

Long -term oral high doses of paracetamol increases the anticoagulant effect of COUMARIN and indandione derivatives.

Need to pay attention to the likelihood of serious antipyretics in patients with simultaneously phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturate, Carbamazepine) that causes enzyme induction in the liver microsome, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction.

The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid.

usually do not need to reduce the dose in patients with simultaneously doses of paracetamol treatment and anti -convulsions. However, patients must restrict self -use of paracetamol while taking anti -convulsions or isoniazid.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30ºC.

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