Pecrandil 10 Ha Tay room and long -term treatment of stable angina (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Nicorandil

Ingredient

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Composition information	Content
Nicorandil	10mg

Uses

indications

Pecrandil 10mg drug used in the following cases:

Prevent and treat long -term stable angina (including reduced risk of acute coronary syndrome in high -risk patients). Nicorandil is also a potassium channel that relaxes both arteries and large coronary arteries, and the nitrate group also causes varicose veins through stimulation of Ganylate Cyclase. Therefore, the drug reduces both the burden, the burden and improves the blood flow to the coronary artery.

Pharmacokinetics

absorption: Nicorandil absorbs well through the gastrointestinal tract.

Distribution: Peak concentration in plasma is achieved after drinking 30-60 minutes.

Metabolism: Metabolic mainly through reducing nitrate.

Elimination: About 20% of the dose is discharged through urine in the form of metabolism. The sale time is about 1 hour. Nicorandil mounting ratio with low plasma proteins.

Before taking Pecrandil 10 Ha Tay room and long -term treatment of stable angina (6 blisters x 10 tablets)

How to use

Pecrandil 10mg drug used orally.

Dosage

Preventing acute coronary events:

Initially 10 mg, 2 times/day (or 5 mg, 2 times/day for patients with headaches), increasing if necessary to 30 mg, 2 times/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Management: Control cardiac function and common supportive treatment. If not successful, increase the volume of circulating by compensation. In case of life -threatening, considering the use of vasoconstrictor drugs.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Pecrandil 10mg drugs often experience unwanted effects (ADR) such as:

Headache (usually fleeting and encountering at the time of treatment), vasodilation under the skin and blushing, vomiting, nausea, dizziness, fatigue.

Rare: muscle pain, skin rash, mouth ulcer. Pressure and mouth ulcers may appear late and more common when using high doses.

Very rare: angioedema, liver dysfunction. Reducing blood pressure and/ or increasing heart rate may be encountered at very high doses.

Instructions on how to handle ADR:

Must stop treatment if there is a thrust or persistent anal ulcer.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pecrandil 10mg drug is contraindicated in the following cases:

Hypersensitivity to Nicorandil or any ingredients of the drug.

Be cautious when used

New myocardial infarction, lower blood pressure, heart valve disease with hemodynamic disorders (which is risk of reducing blood pressure more severe or anemia)

Atrial atrial conduction disorders.

Lactose-containing drug ingredients: Do not use in patients with glucose intolerance, lactase deficiency, or glucose-galactose.

The effect of the drug on the ability to drive and operate machinery

like other cardiovascular drugs, the effect of lowering blood pressure can lead to dizziness, fatigue. Therefore, cautious when using the drug for the driver and operating machinery.

Use drugs for women during pregnancy and lactation

Pregnancy: Although animal studies show that there is no nicorandil side effects in the fetus, because there is no sufficient clinical data on humans, Nicorandil only use Nicorandil in pregnant women after having carefully considering benefits and risks.

Breastfeeding period: It is not known whether the drug is through breast milk, so it is necessary to be cautious when using Nicerandil for breastfeeding women.

Drug interaction

simultaneous use of Nicorandil with 5-phosphodiesterase inhibitors (such as Sildenafil, Tadalfil, Vardenafil) is contraindicated because it can lead to serious hypotension (copper effect).

Simultaneous use of nicorandil with Ganylate Cyclase stimulant (such as Riociguat) is contraindicated because it can lead to serious hypotension.

Nicorandil's treatment can reduce blood pressure in low blood pressure patients.

If Nicorandil is used with drugs for hypertension or substances that work to lower blood pressure (such as vasodilators, 3 -ring antidepressants, alcohol), hypotension can increase.

Be cautious when using nicorandil with dapoxetin due to hypotension.

Demonstrate puncture when used simultaneously Nicorandil and Corticosteroids have been reported.

Be cautious when using simultaneously.

Patients use Nicorandil simultaneously with NSAID, including aspirin in doses for preventive effects on cardiovascular disease and anticoagulant, which will increase the risk of serious complications such as ulcers, perforation and gastrointestinal bleeding.

Be cautious when taking Nicorandil with drugs that increase potassium.

The metabolism of Nicorandil is affected without significance by cimetidin (CYP inhibitors), rifampicin (CYP3A4 induction). Nicorandil does not affect the pharmacokinetics of acenocoumarol.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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