Penicillin G 1 000 000 IU MEKOPHAR treatment for infections (50 vials)

Dosage form Box of 50 bottles
Specifications Benzylpenicilin sodium

Ingredient

Composition information	Content
Benzylpenicilin sodium	1000000iu

Uses

Indication

Penicillin G 1 000 000 IU is indicated in the following cases:

Treatment of infections caused by penicillin G -sensitive strains as

Infection wounds and bacterial infections in the nose, throat, nasal sinus, respiratory and middle ear. Pneumococcus. Penicillin G kill bacteria by inhibiting the synthesis of bacterial cell walls.

antibacterial spectrum:

Gram -positive: Gram -positive bacteria include Streptococcus group B, Clostridium spp. Penicillin is currently reduced). Benzylpenicillin into the bloodstream quickly after intramuscularly and usually reach a maximum concentration within 15-30 minutes.

Distribution: Benzylpenicillin widely distributed with different concentrations in tissues and body fluids. About 60% of plasma protein -attached drugs. Sales time in plasma is about 30-50 minutes in normal patients, 7 -10 hours in patients with renal impairment and in case of impairment of both liver and kidneys, the sale time in plasma can last up to 20 - 30 hours.

Metabolism - excretion: Benzylpenicillin is metabolized and then quickly excreted in the renal tubules to urine.

Before taking Penicillin G 1 000 000 IU MEKOPHAR treatment for infections (50 vials)

How to use

intramuscularly, slow intravenous injection or intravenous infusion. Penicillin G solutions should be used immediately after mixing.

Mix injection solution:

Injecting solution: 1 million IU (600mg) Dissolve in 2ml of distilled water injected. Using

Dosage depends on the condition, the sensitivity of bacteria to antibiotics, weight, age and kidney function of the patient.

Adults and children over 12 years old: 1 - 4 million lu/day, divided 2-3 times (0.6g - 2.4g/day). (75mg/kg/day).

Patients with reduced renal function: Penicillin G's accumulation risk, thus increases the risk of toxicity to the central nervous system. The 24 -hour dose needs to be reduced and the time gap between the doses must be longer (such as 3G, every 12 or 24 hours) or lower the dose in each injection.

Patients over 60 years of age: Should reduce 50% of the usual adult dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

If the overdose occurs, it is recommended to go to the nearest medical facility immediately, so that the medical staff will have a timely treatment method.

What to do when you forget 1 dose? Do not double the dose to compensate for the forgotten dose.

Side Effects

When using penicillin g 1 000 000 IU , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Outdoor, thrombosis.

Uncommon, 1/1000

Eosin leukemia, urticaria .

Anaphylactic reaction, anemia hemolysis, leukopenia.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Penicillin G 1 000 000 IU Contraindicated in case of hypersensitivity to antibiotics of penicillin, cephalosporin.

Be cautious when using

Absolutely be careful with people with a history of allergies to penicillin and cephalosporin, due to the risk of cross -to -immune reactions between benzylpeniciilin and cephalosporins.

Caution for patients with impaired renal function, especially in elderly and infant patients.

For patients with heart failure, special attention should be paid, due to the risk of sodium hyperemia after high doses of penicillin g.

Special caution especially when using high doses of penicillin g for patients with epilepsy.

There may be hypersensitivity to the skin when exposed to antibiotics, so be careful to avoid exposure to the drug. Need to find out that patients have a history of allergies, especially drug allergies because they are easy to increase sensitivity to penicillin.

Using high doses of penicillin g can lead to hypokalemia and sometimes hyperiemia. Should be used with diuretics to keep potassium.

For patients with renal function, high doses (over 8g/day/adult) can cause brain irritation, convulsions and coma.

The ability to drive and operate machinery

has not recorded a adverse reaction report or no research on the effects of the drug on the ability to operate machinery, train drivers, higher people working and other cases.

Pregnancy

only use penicillin g for pregnant women when really necessary.

breastfeeding period

Be cautious when using penicillin g for breastfeeding women.

Drug interaction

Concentrated antibiotics (such as erythromycin, tetracycline) can reduce the bactericidal effect of penicillin by slowing the growth rate of bacteria.

Penicillin concentration in the blood may last when used simultaneously with probenecid by preventing penicillin secretion in the renal tubules. This interaction can be used in treatment to achieve higher and longer plasma concentrations.

Cimetidine may increase penicillin bioavailability.

aspirin, indomethacin, phenylbutazone, sulfaphenazole and sulfinPyrazone extended the waste time of benzylpenicillin.

chloramphenicol may reduce the effect of penicillin in the treatment of meningitis caused by pneumococcus. Therefore, it is necessary to use penicillin to kill bacteria a few hours before using chloramphenicol.

The effect of normal oral anticoagulants, not affected by penicillin, but in particular can increase prothrombin time and cause bleeding when patients use penicillin G. Therefore, it is necessary to monitor when used simultaneously, to be able to predict and handle promptly.

Methotrexate excretion from the body may be significantly reduced due to simultaneous use with penicillin. Need to take care and monitor patients carefully when using methotrexate with penicillin. Check platelets, leukocytes 2 times a week, in the first two weeks, and determine the concentration of methotrexate if suspected to be toxic and treat infections if needed.

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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