Phaanedol Plus Extra Strengh USA - Nic Pharma reduces mild to medium pain, fever (180 tablets)

Dosage form Box of 180 capsules
Specifications Paracetamol, caffeine

Ingredient

Composition informationContent
Paracetamol500mg
Caffeine65mg

Uses

Indications

Phaanedol Plus Extra Strengh 500/65 USA - NIC 180V is indicated in the following cases:

Reducing mild to medium and fever -reducing pain includes: headache, migraine, muscle aches, dysmenorrhea, sore throat, muscular pain, fever and pain after vaccination, pain after tooth extraction or after dental procedures, toothache, osteoarthritis pain.

Pharmacokology

Paracetamol (acetaminophen or N-acetyl-P-Aminophenol) is an active metabolic substance of phenacetin, an effective analgesic-antipyretic drug that can replace aspirin, but different from aspirin, paracetamol is not effective in inflammatory treatment. With the equal dose calculated by gram, paracetamol has an analgesic and antipyretic effect similar to Aspirin. Paracetamol reduces the body temperature, but rarely reduces normal human body temperature.

The drug acts on the hypothalamus, causing cooling off, increasing heat due to vasodilation and increased peripheral blood flow. Paracetamol with treatment dose, less impact on the heart and respiratory, does not change acid-base balance, does not cause irritation, scratches or stomach bleeding like salicylate, because paracetamol does not work on the body cyclooxygenase, only acting on cyclooxygenase/prostaglandin A of central nervous system.

Paracetamol does not work on platelets or bleeding time. When an overdose of paracetamol, a metabolic substance is N-acetyl-benzoquinonimin that is toxic to the liver. Normal dose, paracetamol is well tolerated, without many side effects like aspirin. However, acute overdose (over 10g) causes liver damage can lead to death.

caffeine: caffein is a drug of Xanthin. Cafeine works on the central nervous system, caffeine stimulates priority on the cerebral cortex, reduces the feeling of fatigue, drowsiness, increases the excitement of the cerebral cortex, increases the feeling of the senses thus increasing the ability to work and work more clearly. However, continuous and prolonged caffeine used, after the excitement is the inhibitory period.

pharmacokinetic

paracetamol

absorption

Quick and almost completely through the gastrointestinal tract, reaching the peak concentration of plasma about 30 minutes to 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or people with liver damage. After the treatment dose can be found 90 - 100%of the drug in urine on the first day, mainly after the combination of the liver with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine ​​(about 3%) also detect a small amount of hydroxyl -glaze and acetyl reducing substances. Young children are less likely to be more than adults than adults than adults.

Paracetamol is n-hydroxylation by cytochrom P450 to create N-acetyl-Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus reducing the active loss. However, if you take high doses of paracetamol, this metabolic is made up of the sufficient amount to exhaust the glutathion of the liver, in that situation, its reaction to the sulfhydryl group of the liver protein increases, which can lead to liver necrosis.

caffein

Thinking quickly absorbed by oral and injectable, oral bioavailability reaches over 90%. The drug reaches the maximum concentration in plasma after taking the drug about 1 hour. The drug is widely distributed in the body, through the placenta and breast milk. Distribution volume 0.4 - 0.6L/kg.

Metabolism

Metabolic drugs in the liver with Demethyl reaction and oxidation.

Elimination

Mainly metabolic excreted drugs. The sale time is about 3-7 hours, lasting longer in infants and premature babies.

Before taking Phaanedol Plus Extra Strengh USA - Nic Pharma reduces mild to medium pain, fever (180 tablets)

How to use

phaanedol plus extra structure 500/65 USA - Nic used orally.

Dosage

Adults

Take 1 tablet at a time, 3-4 times a day.

Children aged 12 years and older

Take 1 tablet at a time, 1-2 times a day.

Notes

The distance between 2 times is used from 4 - 6 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

paracetamol

Paracetamol poisoning can be used by a single -dose, or due to a large dose of paracetamol or for a long -term medication. Annexic liver necrosis is the most serious toxic effect due to overdose and can be fatal. Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poison of the drug.

methemoglobin-thus, leading to purple blue, mucosa and nails are a sign of acute poisoning p-aminophenol, a small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated, and delirium. Next can be inhibiting the central nervous system, stunned, lower body heat, tired, fast breathing, shallow, fast, weak, uneven, low blood pressure and circulatory failure. Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2-4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of plasma bilirubin can also increase. In addition, when the liver lesions spread, the long prothrombin time.

Treatment

Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the supplementation of glutathion reserves in the liver, N-acetylcystein works when taken or intravenously. It must be given immediately if less than 36 hours after taking paracetamol. Treatment with n-acetylcysteine ​​is more effective when giving the drug for less than 10 hours after taking paracetamol.

caffein

High dose causes vibration.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose. However, it is necessary to ensure the distance between 2 times used from 4 - 6 hours.

Side Effects

When using Phaanedol Plus Extra Strengh 500/65 USA-NIC 180V, you may experience unwanted effects (ADR).

paracetamol

Leather rash and other allergic reactions may occur. Usually the erythema or urticaria, but sometimes worse is accompanied by a fever due to drugs or mucosal damage. A few individual cases, paracetamol can cause neutropenia, thrombocytopenia and all bloody platelets.

Uncommon, 1/1000

  • DA: Ban.
    • stomach - intestines: nausea, vomiting.
  • Hematology: Dehydration, neutropenia, all bloody hemocytes, leukopenia, anemia.
    • kidney: kidney disease, kidney toxicity when abusing for a long time.

    Rare, ADR

  • Hypersensitivity reaction.

    • caffeine

    can cause stimulation of the gastrointestinal tract and stimulate the central nervous system.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Phaanedol Plus Extra Strengh 500/65 USA-NIC 180V contraindications in the following cases:

  • Paracetamol: People with a history of paracetamol sensitivity, patients with many times anemia or heart, lung disease, people with glucose-6-phosphate dehydrogenase deficiency, liver, kidney failure, children under 12 years old.
    • Cafe: Coronary insufficiency, myocardial infarction, tachycardia, extra mind.

    Precautions when using

    paracetamol

    Paracetamol is relatively non -toxic to treatment. Sometimes there are skin reactions such as rash, itchy and urticaria, other emotional reactions including laryngeal edema, angioedema and anaphylactic reactions that may rarely occur. Platelets, leukopenia and all bloody hematuria have occurred with the use of p-aminophenol conductions, especially when used for large doses. Neutral leukopenia and thrombocytopenic decrease occur when using paracetamol.

    Must use paracetamol carefully in patients with anemia before, because purple blue may not manifest clearly, although there are dangerous high concentrations of methemoglobin high in the blood. Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol. Use carefully with people with impaired liver or kidney function. Doctors should warn patients on signs of serious skin reactions such as Steven-Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute overseas pustules syndrome (AGEP).

    The ability to drive and operate machinery

    is allowed to use when driving and operating machinery.

    Pregnancy

    Take the drug under the instructions of the physician.

    Breastfeeding period

    Drug interaction

    paracetamol

    Long -doses of high -dose Paracetamol increases the anticoagulant effects of cooumarin and indoors. This effect seems less or not clinically important, so paracetamol is more popular than salicylate when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin or indandion.

    Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

    Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver.

    In addition, simultaneous use of isoniazid with paracetamol can also lead to an increased risk of toxicity to the liver, but it has not yet been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid.

    caffein

    caffeine reduces blood flow to the liver, thus prolonging the half -life and increasing the concentration of liver elimination.

    Storage

    In a cool dry place, temperatures below 300C, avoid light.

    Expiry date: 36 months from the date of production.

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