Pharmox 250 Imexpharm medicine treats infections, acute sinusitis (200 tablets)
Dosage form Box of 200 tablets
Specifications Amoxicillin
Ingredient
| Composition information | Content |
| Amoxicillin | 250mg |
Uses
Indications
Amoxicillin is indicated in the following cases:
Mobile pharmacokinetic/pharmacokinetic relationship: The time of antibiotic concentration is higher than the minimum inhibitor (T> MIC) is the main parameter that shows the effect of amoxicillin.
The two main anti -drug mechanisms of amoxicillin are:
The effect of the drug:
In vitro sensitivity level of microorganisms with amoxicillin
common sensitive species
Aerobic gram -positive bacteria:
The species that the drug resistance may be the problem
Aerobic gram -negative bacteria:
Aerobic gram -positive bacteria:
anaerobic gram bacteria:
Anaerobic gram bacteria:
Other:
Microorganisms that have been resistant to drugs
Aerobic gram -positive bacteria:
Aerobic Gram -negative bacteria:
Other:
(2) Intermediate sensitivity level without an infected drug mechanism.
pharmacokinetic
absorption
Amoxicillin completely dissociates in physiological pH solution. Amoxicillin is well absorbed and fast when used orally. Absorption is not affected by food, fast and completely through the gastrointestinal tract compared to ampicillin. When taken at the same dose like ampicillin, the concentration of amoxicillin peak in plasma is at least 2 times higher. Oral bioavailability of amoxicillin is about 70%. The time for Amoxicillin to reach the maximum concentration in plasma is about 1 hour after drinking.
Distribution
About 18% of the total amount of amoxicillin associated with plasma proteins and the apparent distribution volume is about 0.3 - 0.4 l/kg. After intravenous injection, Amoxicillin is found in the gallbladder, abdominal tissue, skin, fat, muscle tissue, joint fluid and peritoneal fluid, bile and latex. Amoxicillin is not much distributed in cerebrospinal fluid.
Research on animals shows no evidence for significant accumulation of drugs at tissue.
As most of other penicillin antibiotics, amoxicillin can be distributed into breast milk. Amoxicillin can pass the placenta.
Metabolism
Amoxicillin is partially converted into peniciloic acid in the form of inactiveness in urine with an amount equivalent to 10-25% of the starting dose.
Elimination
Amoxicillin is excreted mainly through the kidneys.
Amoxicillin has an average time of selling about 1 hour and the average total total clearance of about 25 l/hour in healthy people. About 60 - 70% amoxicillin is eliminated in urine in the form of unchanged in the first 6 hours after taking a single dose of 250mg or 500mg amoxicillin. Other studies show that about 50 - 85% amoxicillin is eliminated through urine after 24 hours.
Age: Amoxicillin's sale time in children is about 3 months to 2 years of age equivalent to older children and adults. For young children (including premature babies) in the first week after birth, the distance between the drug use should not exceed twice daily due to the incomplete excretor function of the kidney. Because the elderly people have a higher impairment of renal function, it is necessary to be cautious when choosing the dose and monitoring the kidney function throughout the treatment process.
Sex: In women and men healthy after taking Amoxicillin shows that gender does not significantly affect the pharmacokinetics of amoxicillin.
Renal failure: Amoxicillin's total serum clearance ratio decreases corresponding to the impaired renal function.
Hepatic failure: Patients with liver failure should take care of the drug and monitor the periodic liver function.
Before taking Pharmox 250 Imexpharm medicine treats infections, acute sinusitis (200 tablets)
How to use
Pharmox 250mg Used orally.
Take the whole pill with a little water. Food does not affect the absorption of drugs.
Dosage
The choice of Amoxicillin dosage depends on the following factors:
Adults and children> 40 kg
Indications
Dosage
250 - 500mg every 8 hours or 750mg -1g every 12 hours.
with severe infections: 750mg - 1g every 8 hours.
Treatment of acute cystitis with 3g x twice a day, used for 1 day.
Acute pyelonephritis
Acute cystitis 500mg Every 8 hours, or 750mg -1g every 12 hours. With severe infections: 750mg - 1g every 8 hours, used for 10 days.
500mg - 1g every 8 hours.
500mg - 2g every 8 hours.
Old joint infection 500mg -1g every 8 hours. 2G oral orally, take a single dose before conducting surgery 30 to 60 minutes.
Helicobacter pylori treatment
750mg - 1g, 2 times/day, in combination with proton pump inhibitors (for example, omeprazol, Lansoprazol) and other antibiotics (eg clarithromycin, metronidazol), used for 7 days.
Lyme disease
Early phase: 500mg - 1g every 8 hours to a maximum of 4 g/day divided into several doses, used in 14 days (10 to 21 days).
Late period (body manifestation): 500mg to 2g every 8 hours to maximum 6 g/day divided into doses, used for 10 to 30 days.
Dosage for children under 40 kg and can swallow hard capsules (children from 5-11 years old, equivalent to 20 - 40 kg):
Indications
Dosage
Reference dose on 250 mg capsules
Pneumonia has a community
Supply cystitis
Acute pyelonephritis
Dental abscess with widespread cell inflammation
20 to 90 mg/kg/day, divided into 2 times/day
Children from 20 - 25 kg: 1 capsule 2 times/day. Can increase the dose of 4 capsules 2 times/day.
Children from 25kg or more to
40 to 90 mg/kg/day, divided into 2 times/day
Children from 20 - 25 kg: 2 capsules 2 times/day. Can increase the dose of 4 capsules 2 times/day.
Children from 25 kg or more to
100 mg/kg/day, divided into 3 times/day
Children from 20 - 25 kg: 3 capsules x 3 times/day.
Children from 25 kg or more to
50 mg/kg oral orally, oral orally, oral dosage before conducting surgery 30 to 60 minutes
Children from 20 - 25 kg: 4 tablets, single dose.
Children from 25 kg or more up to 30 kg: 5 capsules, single dose.
Children from 30 kg or more to
(can use other products containing amoxicillin content more suitable).
Early phase: 25 - 50 mg/kg/day, divided into 3 times/day, use 10 to 21 days
Early phase: Use 10 to 21 days.
Children from 20 - 30 kg: 1 tablet x 3 times/day.
Children from 30 kg or more to
Late period (body manifestation): Use 10 to 30 days.
Children from 20 - 25 kg: 3 capsules x 3 times/day.
Children from 25 kg or more to
Patients with renal failure:
gfr (ml/minute)
adults and children> 40 kg
Children
30
No dose adjustment
No dose adjustment
10-30
Maximum of 500mg x 2 times/day
15 mg/kg x 2 times/day (maximum 500 mg 2 times/day)
up to 500 mg/day Single dose 15 mg/kg/day (maximum 500 mg) Adults and children over 40 kg 500mg every 24 hours. Before hemolysis, should use an additional 500mg. To recover the concentration of drugs during blood circulation, after hemolysis, one more dose of 500mg. Single dose 15 mg/kg/day (maximum 500mg). Before the hemolysis, the dose of 15 mg/kg should be used. To recover the concentration of drugs during blood circulation, after hemolysis, one more dose of 15 mg/kg should be used. Hepatic failure: Precautions when using the drug and periodically monitor liver function. What to do when overdose? The imbalance of water - electrolytes should be treated as symptoms. In the process of using high doses of amoxicillin, it is necessary to maintain a satisfactory amount of drinking water and eliminate out of the urinary tract to minimize the possibility of amoxicillin crystal crystal (can lead to renal failure). Amoxicillin can be removed from the circulatory system with hemolysis. What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Ampicillin MKP 500, you may experience unwanted effects (ADR).
Commondiarrhea, nausea; Rash.
rarely
vomiting; Urticaria, itching.
Very rare
Skin reactions such as diverse roses, Steven -Johnson syndrome, poisoned epidermal necrosis, water -glossy dermatitis and peeling, external pustular syndrome (AGEP) and side effects due to drugs with acidic hypernage and systemic symptoms (Drug Reaction with Eosinophilia and System Symptoms - Dress); Dress); Dress); Dress); Dress); Dress); Dress); Dress); Dress); Dress); Dress); Interstitial nephritis, urinary crystals; Candida mucosa infection; Reducing leukocytes with recovery, reduced thrombocytopenia, hemolytic anemia, prolonging prothrombin time; Serious allergic reactions: angioedema, neuritis, anaphylaxis ...
unknown frequency
Jarisch reaction - Herxheimer.
Instructions on how to handle ADR:
Amoxicillin's undesirable reactions in the gastrointestinal tract, in blood often disappear when stopping treatment. When colitis has a fake film, it is necessary to supplement water, electrolytes and proteins; Metronidazol and oral vancomycin treatment. Movement, other types of rash and serum -like reactions can be treated with antihistamines, and if necessary, using systemic corticosteroid therapy. However, when such a reaction occurs, amoxicillin must be stopped, unless there is a physician's opinion in special cases, life -threatening that only Amoxicillin can resolve.
If allergic reactions occur such as erythema, iron, anaphylaxis, Stevens-Johnson syndrome, amoxicillin must be stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticoid therapy and ventilation, including internal trachea and never being treated with penicillin or cephalosporin.
Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Pharmox 250 Contraindications in the following cases:
Precautions when using
must periodically check the liver and kidney function during long -term treatment.
There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so it is necessary to carefully investigate the history of allergies to penicillin, cephalosporin and other allergens.
If the allergic reaction occurs such as erythema, edema, anaphylactic shock, Steven-Johnson syndrome, amoxicillin must be stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticosteroids and ventilation, including internal trachea and never treatment with penicillin or catphalosporin.
Renal failure: In patients with renal failure, the dose of treatment should be adjusted based on the degree of renal failure.
Side side effects:
Jarisch-HERXHEIMER reaction: Jarisch-HERXHEIMER reaction has been seen after treating lympha with amoxicillin. It is a direct result of amoxicillin's bactericidal activity in Lyme -causing bacteria (Borrelia Burgdorferi), which should be notified to the patient that this is a common result and often recovered from antibiotic treatment.
Excessive growth of uncertainty microorganisms:
Anticoagulants: Prothrombin time has been reported in patients treated with amoxicillin, but it rarely occurs. Therefore, patients should be monitored when using Amoxicillin simultaneously with anticoagulant drugs. Can adjust the anticoagulant dose if needed to maintain the concentration of anticoagulants as desired.
urinary crystal: In patients with decreased urine, may experience crystal but very rare, mainly occurs when treated with injection. During the high doses of amoxicillin use should maintain the amount of drinking water and the amount of urine discharged to reduce the ability to form amoxicillin crystals, in patients using bladder catheter, need to regularly check the ventilation of the pipe.
affect diagnostic tests: The presence of amoxicillin in serum and urine may affect the results of certain tests such as false positive results in urine glucose tests by chemical methods. When needing glucose testing in urine should use testing methods using glucose oxidase.
The presence of amoxicillin can also affect the quantitative results of oestriol in pregnant women.
The ability to drive and operate machinery
There has been no research on the effects of drugs on driving and operating machinery. However, unwanted effects may occur (such as allergic reactions, dizziness, convulsions), may affect the ability to drive and use machinery.
Pregnancy
Safety when using amoxicillin during pregnancy has not been clearly defined. Therefore, only use the drug when really necessary. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women.
Breastfeeding period
Because amoxicillin is excreted into breast milk, and can be sensitive. Therefore, diarrhea and fungal infection on mucous membranes can occur in infant breastfeeding. Amoxicillin should only be used during breastfeeding after assessing the benefits for the mother and the risk of babies.
Medicinal interaction
Absorption of Amoxicillin is not affected by food in the stomach, so it can be taken before or after meals.
Probenecid: Do not use amoxicillin simultaneously with probenecid. Probenecid reduces amoxicillin secretion in the renal tubules. Simultaneous use with amoxicillin may increase and prolong the concentration of amoxicillin in the blood.
Allopurinol: Used in combination with allopurinol during treatment with amoxicillin may increase skin allergic reactions.
Tetracyclin: Tetracyclin antibiotics and other bactericidal drugs can effectively hinder the bactericidal effect of amoxicillin.
Oral anticoagulants: Oral anticoagulants and penicillin antibiotics have been widely used in reality without noting any interactions. However, in the literature, it refers to increasing international normalization index (INR) in patients using acenocoumarol or warfarin simultaneously with amoxicillin. If it is necessary to use simultaneously, carefully monitor prothrombin or INR time when starting or stopping amoxicillin. Adjust the anticoagulant dose when necessary.
Methotrexate: Penicillin antibiotics reduce methotrexate secretion, thus increasing the toxicity of methotrexate.Storage
Leave a cool place, avoid light, temperature below 30 ° C.
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