Pharmox Imp 1g Imexpharm medicine for infection (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin

Ingredient

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Composition information	Content
Amoxicillin	1000mg

Uses

indications

Pharmox IMP drugs are indicated in the following cases:

Amoxicillin is indicated to treat infections caused by sensitive bacteria in adults and children, including:

acute bacterial sinusitis;

acute otitis media; > Acute pyelonephritis; > Pharmacy

Pharmacological group: Penicillin antibiotics with wide antibacterial spectrum.

ATC code: J01CA04.

antibacterial mechanism:

Amoxicillin is a semi-synthetic antibiotic belonging to the penicillin group (beta-lactam antibiotic). Amoxicilin has bactericidal effects that attach to one or more protein of bacterial penicillin (Pbps) to inhibit peptidoglycan biosynthesis, which is a component of bacterial cell walls. Finally, the bacteria decompose by the self-destructed enzymes of the bacterial cell wall.

The time for antibiotic concentration is higher than the minimum inhibitory concentration (T> Mic) is the main parameter that shows the effect of amoxicillin.

resistance mechanism:

The main mechanisms of amoxicillin resistance are:

Inactive drugs by bacterial beta-lactamase.

antibacterial spectrum:

often sensitive bacteria: Aerobic Gram -positive bacteria: Enterococcus Faecalis, hemolytic bacteria B (group A, B, C and G), Listeria monocytogenes.

Bacteria may have problems with drug resistance:

Aerobic Gram -negative bacteria: Escherichia Coli, Haemophilus influenzae, Helicobacter Pylori, Proteus Mirabilis, Salmonella Typhi, Salmonella Paratyphi, Pasteurella Multocida. Aureus, Streptococcus Pneumonia, Viridans streptococcus.

Aerobic Gram -positive bacteria: Enterococcus Faecium. (Many bacterioides fragilis strains are resistant to

drug).

: Chlamydia spp.

Amoxicillin is completely dissociated in water solution in physiological pH. It is absorbed well and quickly after drinking. After drinking, the bioavailability of amoxicillin is about 70%. The time to reach the peak concentration in plasma is about 1 hour. hour) t1/2 2.0)

26.7 ± 4.56 1.36 ± 0.56 The absorption of the drug is not affected when used simultaneously with food.

Hemolysis can be used to eliminate amoxicillin from the body.

distribution:

about 18% amoxicillin associated with plasma proteins. The apparent distribution volume is about 0.3-0.4 l/kg. Amoxicillin is not much distributed in cerebrospinal fluid. Like other antibiotics of penicillin groups, amoxicillin through the placenta fence and distributed into breast milk.

about 10 - 25% amoxicillin in the starting dose is excreted in urine in the form of peniciloic acid that does not work.

excretion:

Amoxicillin is excreted mainly through the kidneys. Nearly 60 - 70% amoxicillin is eliminated in urine in the form of unchanged in the first 6 hours after taking a single dose of 250 mg or 500 mg of amoxicillin. Other studies show that about 50 - 85% amoxicillin is eliminated through urine for 24 hours.

Amoxicillin's sale time in children from 3 months to 2 years old, older children and similar adults. For young children (including premature babies) in the first week after birth, the distance between the drug use should not exceed twice daily due to the incomplete excretor function of the kidney. For elderly patients, because it is more likely to be impaired renal function, it should be noted when choosing the dosage and should be monitored with kidney function.

Sex: After giving amoxicillin in healthy women and men shows that gender does not significantly affect the pharmacokinetics of amoxicillin.

Patients with renal failure:

The total serum clearance coefficient of amoxicillin decreases corresponding to the impaired renal function.

Patients with liver failure:

Patients with liver failure should be carefully indicated and monitored liver function periodically.

Before taking Pharmox Imp 1g Imexpharm medicine for infection (2 blisters x 7 tablets)

How to use

Take oral use.

Amoxicillin's absorption is not affected by food.

The drug can be used in two ways: dispersing drugs in the water to create a drink, or drink directly with water. Can break the medicine to easily swallow. Dosage

Selecting Amoxicillin dosage should be based on the following characteristics:

Suspected pathogens and their sensitivity to antibiotics. Dosage

Severe infections: 1 g (equivalent to 1 tablet) every 8 hours.

Acute cystitis can be treated with a dose of 3 g/time (equivalent to 3 tablets/time), 2 times/day, for 1 day.

Unematurized urinary tract infections during pregnancy >

1 g (equivalent to 1 tablet) every 12 hours.

Severe infections: 1 g (equivalent to 1 tablet) every 8 hours, for 10 days.

Amiddan inflammation and acute streptococcal sore throat (equivalent to 2 tablets) Every 8 hours. Pylori 1 g/time (equivalent to 1 tablet/time), 2 times/day in combination with Proton pump inhibitors (such as omeprazol, Lansoprazol) and other antibiotics (such as Clarithromycin, Metronidazol) in 7 days. Every 8 hours to a maximum of 4 g/day, divided doses, used in 14 days (10 - 21 days).

The following phase: 2 g (equivalent to 2 tablets) every 8 hours to a maximum of 6 g/day, divided doses, used for 10-30 days.

Dosage Dosage Dong

acute cystitis Time/day. First: 25 - 50 mg/kg/day, 3 times/day for 10 - 21 days.

The following phase: 100 mg/kg/day divided 3 times/day for 10 - 30 days.

Patients with renal failure:

gfr (ml/min) adults and children ≥ 40 kg 40 kg# 30 Maximum dose of 500 mg, 2 times/day. Priority infusion.

Patients with hemolysis:

Adults and children ≥ 40 kg: Dosage 15 mg/kg/day, single dose. Use before the divergence of an additional dose of 15 mg/kg and to maintain the concentration of medication in the blood, the dose of 15 mg/kg should be used after the fertilizer.

Patients with peritoneal fertilizer:

Maximum dose of 500 mg/day.

Patients with liver failure:

Use medication carefully and periodically monitor liver function.

Treatment time: Depending on the type of infection and response of the patient. The shorter treatment time is as shorter. Some bacterial diseases need longer treatment time.

Some special notes on drug treatment before and after using the drug:

There is no special requirement on drug treatment after use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

overdose:

The common manifestations of amoxicillin overdose are digestive disorders (such as nausea, vomiting, diarrhea) and water and electrolyte disorders. Observed the urinary amoxicillin crystal, in some cases, the kidney failure. Convulsions can occur in patients with renal failure or patients with high doses.

How to handle:

Stop using drugs, treat symptoms on the gastrointestinal tract and maintain water/electrolyte balance. Amoxicillin can be removed from circulation by hemolysis method.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

The most unwanted reaction of the most common drug is diarrhea, nausea and skin rash.

Common (1/100 ≤ ARD Digestive system: diarrhea, nausea.

The digestive system: vomiting.

infection and parasitic infection: Candida infection on the skin mucosa. Extend bleeding time and prothrombin time

The immune system: Heavy allergic reactions including nerveemia, anaphylaxis, serum and hypersensitivity. This application is reported in children. Good dental hygiene will prevent this side effect).

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Pharmox IMP drug contraindicated in the following cases:

Hypersensitivity to amoxicillin, other penicillin antibiotics or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Hypersensitivity reaction:

Before starting amoxicillin treatment, it is necessary to learn about the patient's allergic history with penicillin, cephalosporin or other beta-lactam antibiotics.

Severe hypersensitivity reactions and sometimes fatal (such as anaphylaxis and serious side effects) have been recorded in patients treated with penicillin drugs. These reactions often occur in patients with a history of allergies to penicillin and/ or many agents. If the allergic reaction occurs, it is necessary to stop using amoxicillin immediately and choose another appropriate treatment.

Unpake microorganisms:

Amoxicillin is not suitable for the treatment of bacterial infections caused by microorganisms that are not sensitive to drugs. Therefore, only use drugs to treat infections when it has been certified or there is a lot of information that indicates the causes of the disease sensitive to the drug. This is especially applied to treat urinary tract infections and severe bacterial infections in the ear, nose and throat.

convulsions:

Convulsions can occur in patients with impaired renal function or in case of high doses or in patients with risk factors (such as a history of convulsions, being treated with anti -epileptic drugs or meningitis disorders).

Patients with renal failure:

Should adjust the dose for patients with renal impairment depending on the degree of renal failure (see the dose - Usage section).

Side side effects:

When starting to treat with amoxicillin, some patients have a systemic erythema with pustules. These manifestations may be symptoms of acute all -body pustules syndrome (AGEP). At that time, it is necessary to stop using amoxicillin and later, do not use any preparations containing amoxicillin.

Do not use Pharmox IMP 1g for patients suspected of having a mononoculatoculum hypertension because these patients are at risk of measles rash when using amoxicillin.

Jarisch-Hersheimer reaction:

Has the Jarisch-HERXHEIMER reaction after taking amoxicillin to treat Lyme disease. It is a direct result from amoxicillin's bactericidal activity to Lyme -causing bacteria, which are Borrelia Burgdorferi. The patient should know that this reaction is common due to the treatment of Lyme with antibiotics and often goes away on its own.

Excessive growth of uncertainty bacteria:

Take long -lasting drugs, sometimes developing anti -drug bacteria.

Colonitis associated with antibiotics has been reported with almost all antibacterial agents and can fluctuate from mild to life -threatening. Therefore, it is necessary to diagnose this disease in patients with diarrhea during or after medication. If the fake colitis is caused by antibiotics, it is necessary to stop treating immediately with amoxicillin and conduct appropriate treatments. Do not use intestinal inhibitors in these cases.

Prolonged treatment:

Periodically check the function of organs such as kidney and liver function, hematology index during long -term treatment. Cases of hyper enzyme hyper enzyme and changes in the number of blood cells when using amoxicillin.

anticoagulant drugs:

Prothrombin time has been reported in patients treated with amoxicillin, but it rarely occurs. Therefore, it is necessary to monitor patients when using concurrently amoxicillin with anticoagulant drugs. Can adjust the anticoagulant dose if needed to maintain the concentration of anticoagulants as desired.

Crystal:

Very rare cases of observation of the phenomenon of crystal crystal in patients with reduced urine excretion, mainly in patients using amoxicillin in the form of injection. Patients should maintain sufficient oral fluids and excluded in the urine to reduce the ability to cause urinary amoxicillin crystals, especially when taking the drug in high doses. In patients with urinary tract placement, regular checkpoints need catheter.

Interaction with diagnostic tests:

The presence of amoxicillin in serum and urine can affect the results of certain tests such as giving false positive results when testing in urine glucose by chemical methods. Therefore, when a glucose test is needed in the urine, it is necessary to use testing methods using glucose oxidase.

The presence of amoxicillin may also affect the quantitative results of oestriol in pregnant women.

Warning information about excipients:

The drug contains aspartam (content of 20 mg/tablet), Aspartam is hydrolyzed in the digestive tract into phenylalanin. Therefore, patients with phenylketon must be cautious when using this drug.

There is no clinical data as well as clinical data for evaluating the use of aspartam in children under 12 weeks of age.

The effect of drugs on driving and operating machinery

There are no studies on the effects of the drug on the ability to drive and operate machinery. However, some unwanted effects of the drug such as allergic reactions, dizziness, convulsions ... can reduce the ability to focus and react of the patient. Therefore, caution when using the drug for these objects. If the patient has the above unwanted effects, it is not advisable to drive or operate machinery.

Using drugs for women during pregnancy and lactation

Using drugs for pregnant women:

Studies on the use of amoxicillin on animals show that there is no direct or indirect danger to fertility. The data on the use of amoxicillin in pregnant women is limited, but shows that it does not increase the risk of birth defects. Amoxicilin can be used for pregnant women if they assess the benefits higher than the potential risk.

Use medicine for breastfeeding women:

Amoxicillin is excreted in breast milk in small amounts and can cause sensitive reactions in children. This can lead to diarrhea or fungal infection on mucous membranes in breastfed babies, so they should stop breastfeeding while taking the drug to ensure safety for babies. Amoxicillin should only be used during breastfeeding after being assessed by a doctor between benefits and potential risks.

Drug interaction

Probenecid:

Avoid simultaneous use of amoxicillin with probenecid. Probenecid reduces amoxicillin secretion in the renal tubules thus increases and prolongs the concentration of amoxicillin in plasma.

alopurinol:

Concomitant use amoxicillin with alopurinol will increase the likelihood of allergic reactions on the skin.

Tetracycline antibiotics and other bactericidal drugs:

Antibiotics of Tetracyclin and other bactericidal drugs can effectively hinder the bactericidal effect of amoxicillin.

Anticoagulant drugs for oral oral:

Oral anticoagulants and penicillin antibiotics have been widely used in reality without noting any interactions. However, in the literature, it refers to the increase in international normalization (INR) in patients using acenocoumarol or warfarin simultaneously with amoxicillin. If it is necessary to use simultaneously, carefully monitor prothrombin or INR time when starting or stopping amoxicillin. Can adjust anticoagulant dose if needed.

methotrexate:

Penicillin antibiotics reduce methotrexate secretion, thus increasing the toxicity of methotrexate.

Interaction with diagnostic tests:

Glucose test in urine: The presence of amoxicillin in urine can give a false positive result when testing in urine glucose by chemical methods. Therefore, during treatment with drugs when needed glucose testing in the urine should use testing methods using glucose oxidase enzyme.

Quantifying oestriol in pregnant women: the presence of amoxicillin can also affect the quantitative results of oestriol in pregnant women.

The cavalry of the drug:

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Storage 2>

to cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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