Phazandol Extra Phuc Vinh medicine supports pain relief and fever (15 blisters x 12 tablets)

Dosage form Tablet
Specifications Box of 15 blisters x 12 tablets
Ingredient Caffeine, paracetamol
Indication Headache, back pain, inflammation, toothache, osteoarthritis, dysmenorrhea

Ingredient

Thành phần cho 1 viên

Composition informationContent
Caffeine65mg
Paracetamol500mg

Uses

Indications

Phazandol EXTRA indications in the following cases:

  • Phazandol Extra contains paracetamol is an analgesic, antipyretic and caffein -analgesic agent, an enhancement of paracetamol analgesic. For example, in mild analgesic to fit as a headache, including migraine, back pain, toothache, osteoarthritis and dysmenorrhea. The mechanism of action of the drug is thought to inhibit the synthesis of prostaglandin, mainly in the central nervous system. Due to the no effect of inhibiting peripheral prostaglandin, the drug has an important pharmacological properties of maintaining prostaglandin protected at the digestive tract. Therefore, Paracetamol is suitable for patients with a history of disease, or patients who are taking other drugs that have the effect of inhibiting peripheral prostaglandin (for example, a patient with a history of gastrointestinal bleeding or the elderly).

    caffeine acts as an analysis of paracetamol analgesic. The combination of paracetamol - caffeine causes much better analgesic effect than more than conventional paracetamol tablets.

    pharmacokinetic

    paracetamol

    absorption

    paracetamol is absorbed quickly and completely through the gastrointestinal tract.

    Distribution

    Paracetamol is distributed most of the tissues and fluids of the body. At treatment concentration, paracetamol is very small with plasma proteins.

    Metabolism

    Paracetamol is metabolized in the liver and excreted through urine mainly in the form of glucuronid and sulphat.

    Elimination

    less than 5% Paracetamol is excreted in a constant form. Average waste time in plasma is about 2.3 hours.

    caffeine

    absorption

    Caffein is quickly absorbed through the gastrointestinal tract. Maximum drug concentration in plasma is achieved after 1 hour.

    Distribution

    caffeine is widely distributed throughout the body.

    Metabolism and elimination

    caffeine is metabolized almost completely through the liver through oxidation and reduction of methyl produce some xanthin derivatives, then excreted in urine about 65-80% in the form of metabolites.

    The average selling time for the drug in plasma is about 3.5 hours.

    • Before taking Phazandol Extra Phuc Vinh medicine supports pain relief and fever (15 blisters x 12 tablets)

    How to use

    Adults (including the elderly) and children 12 years and older: Using orally only.

    Dosage

    Should use 500 mg Paracetamol/65 mg caffeine to 1000 mg Paracetamol/130 mg Caffeine (or 1-2 tablets) every 4 - 6 hours if needed.

    Maximum dose: Do not take more than 8 capsules per day. Do not use with other drugs containing paracetamol.

    Children under 12 years of age: Do not recommend using drugs for children under 12 years old.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    paracetamol

    When using paracetamol overdose can lead to liver cell damage. If the patient is used in a dosage> 5g and there are risk factors such as using carbamazepin, phenobarbital, phenytoin, primidon, rifampicin, st John wad or alcohol, etc., it can also cause liver cell damage.

    Symptoms of overdose

    In the first 24 hours, the patient shows signs of pale, nausea, vomiting, anorexia and abdominal pain. Hepatic cell damage may start about 12 - 48 hours after taking the medicine.

    Glucose metabolic disorders and metabolic acidosis may occur. When severe poisoning, liver failure can lead to hepatitis, hemorrhage, hypoglycemia, brain edema and death. Acute renal impairment caused by kidney necrosis causes patients to cause lumbar pain, hematuria and proteinuria. Arrhythmic and pancreatitis have also been reported.

    Handling

    Apply medical control measures as soon as an overdose occurs, even when the symptoms of an overdose are not appearing.

    Can be treated with activated carbon if the patient is overdosed within 1 hour. N-acetylcystein treatment can be applied in patients using an overdose of up to 24 hours, but the maximum detoxification effect when the patient uses the drug within 8 hours, then the effect will decrease. The most suitable is to use N-acetylcystein intravenously to ensure the dose.

    It is possible to use oral methionin in case the patient is not vomiting and is being treated in remote areas or in hospitals without N-acetylcystein intravenous sugar.

    In the case of patients with severe liver failure after 24 hours of medication, it is necessary to talk to the National Poisoning Center.

    caffeine

    Symptoms of overdose

    Caffeine overdose can cause stress, restlessness, insomnia, agitation, diuretic, flushing, muscle convulsions, tachycardia or arrhythmia ....

    Handling

    Need to treat overdose symptoms. Activated carbon can be used within 1 hour after taking the drug, but after 4 hours of overdose, it is necessary to consider. The effects on the central nervous system during caffeine overdose can be treated with intravenous tranquilizers.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    Side Effects

    When using phazandol extra often has unwanted effects (ADR) such as:

    paracetamol

    Blood disorders and lymphatic systems:

    Very rare (

    immune system disorders:

    Very rare (

  • Hypersensitivity reaction.

    Very rare (

    Bronchospasm in patients sensitive to aspirin and other NSAIDs.

    caffeine

    Central nervous system:

    Unknown:
  • restlessness.
  • Dizziness.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Primtra phazandol extra is contraindicated in the following cases:

  • Contraindicated paracetamol - caffeine for patients with a history of hypersensitivity to paracetamol, caffeine or any excipients of the drug.

    • Precautions when using

    Doctors need to warn the patient about signs of respected skin reactions such as Stevens-Johnson syndrome (SJS), poisonous skin necrotic syndrome (Spain) or Lyell syndrome, acute foreign pustular syndrome (AGEP).

    There is an increase in the risk of paracetamol harmful to the liver in patients with liver diseases. Patients diagnosed with severe liver failure or severe renal failure should consult a doctor before taking this medication.

    Avoid using caffeine overdose (such as coffee, tea and some other canned drinks) while taking this medication.

    Do not overdose.

    If the millions of eggs are persistent, need to consult a doctor.

    Patients should be recommended to avoid using other products containing paracetamol.

    To be out of reach and vision of children.

    Using drugs for women during pregnancy and lactation

    Epidemiological studies on humans during pregnancy have shown that Paracetamol and Caffeine have no adverse effects on pregnancy when used with recommended doses, but pregnant patients who want to use drugs still need advice from the doctor.

    paracetamol and caffeine excrete in breast milk in negligible amounts. Clinical data published on drugs without contraindications for nursing women.

    The effect of the drug on the ability to drive and operate machinery

    The effect of the drug on the job (operators, driving train, high -class people): No significant impact.

    Drug interaction

    Paracetamol's absorption speed can increase when used with metoclopramid or domperidone and reduce absorption when combined with cholestyramin. The long -term use of paracetamol increases the anticoagulant effect of warfarin and other types of cooumarin leading to an increased risk of bleeding; Non -regular use will not have a significant impact.

    When using the dose recommends paracetamol/caffeine along with a diet high in caffeine, will cause side effects due to caffeine overdose such as insomnia, awake, anxiety, irritability, headache, digestive disorders, suspense.

    Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

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