Phenergan Sanofi skin cream treats itch, itching, and insects (10g)

Dosage form Tube
Specifications Promethazine

Ingredient

Composition information	Content
Promethazine

Uses

indications

Phenergan 2% 10g is indicated in the following cases:

Treatment of itching, itching, insect burning, surface burns, skin irritation due to X -rays.

Pharmacokic

Anti -synthetic anti -synthetic drugs, local anesthesia.

Promethazin is a phenothiazine conductor that is different from mental disorder phenothiazin in the secondary branch circuit and has no replacement in the ring. It is thought that this configuration reduces dopaminergic effect in the central nervous system (only 1/10 of the effect of dopromazin).

Promethazine has antihistamine and sedative effects. Promethazine can inhibit central nervous systems, manifested by sedation, which is common when taking drugs with treatment dose for antihistamine. Promethazin also has anti -vomiting effects, anti -cholinergic, anti -motion sickness and numbness in place.

Promethazine is a H1 receptor blocker due to a dispute with histamine in the positions of the H1 receptor on the acting cells, but does not prevent the release of histamine, so the drug only prevents the reactions created by histamines.

Dynamic pharmacokinetics

absorption: Promethazin is well absorbed through the gastrointestinal tract and in the injection site, used by oral, rectal or intramuscularly, the drug starts antihistamine and sedative effect for 20 minutes. The antihistamine effect can last up to 12 hours or longer, and the sedative effect can be maintained from 2 to 8 hours depending on the dose and sugar.

Distribution: The ratio of binding to plasma proteins from 76% to 93%. The drug is widely distributed to the body's tissues. The drug is easy through the placenta.

Metabolic: Promethazin metabolizes strongly in the liver for the main product, Promethazin Sulphoxid and N-Demethyl Promethazin.

Elimination: Eliminating drugs through urine and feces.

When using skin cream, promethazin is slowly absorbed through the skin. The drug only accumulates mildly in the body, the rate of absorbed into the body of the cream is very low, only enough to work on the spot.

Before taking Phenergan Sanofi skin cream treats itch, itching, and insects (10g)

How to use

topical skin.

Dosage

Apply into thin layer, 3-4 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Toxicity of promethazine is mainly on the anti -anti -anti -cholinergic effect at the Muscarinic receptor: a nerve syndrome, including central neurological inhibition, acute hyperactivity manifestations, loss of transport and hallucinations, apnea associated with peripheral Muscarinic effects.

Handling as an overdose of sedative: Treatment of positive symptoms of the cardiovascular system and respiratory system. In case the skin with topical drugs must be washed without absorbed drugs. Increase excretion, diuretic, vomiting, Flumazenil antagonists, dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using 2% phenergan 10g, you may experience unwanted effects (ADR).

As all active ingredients, in some people, the drug can cause some adverse effects more or less. May cause sensitivity in the skin or sensitivity to light due to allergies to different ingredients in the preparation: Promethazin, Lanolin, Methyl parahydroxybenzoate, etc.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

Phenergan 2% 10g contraindicated in the following cases:

Skin disease due to infection or irritation.

eczema (Eczema).

Be cautious when using

itching is only a symptom. In all cases, it is necessary to find the cause for treatment.

Because the drug contains substances with potential allergens, it is necessary to consider the risk that may be encountered with the benefits of the drug.

Because of promethazin, the drug is at risk of skin sensitivity and sunlight. In the case of skin allergies, it is shown to be caused by promethazin in the cream, a cross -allergy may occur after using phenothiazine by systemic sugar.

Because phenothiazine has a sun -sensitive effect, avoiding sun exposure and exposure to ultraviolet rays during treatment.

Do not use antihistamines for premature or newborn babies because this group is often very sensitive to respiratory inhibiting and anti -cholinergic effects in the central nervous system of the drug. Promethazin should not be used for children under 2 years old because of the unproven safety.

These drugs also avoid used for children with signs and manifestations of Reye syndrome, especially when high doses that can cause symptoms that are easy to mix with the central nerve signs of this syndrome, thereby making it difficult to diagnose.

The ability to drive and operate machinery

When using the cream, the drug is less soaked into the body, so there is no contraindication to use this drug when driving and operating machinery.

Pregnancy

About deformities (in the first three months):

There is no reliable data on promethazin's biofilm on animals.

About pregnancy toxicity (between the three months and the last three months):

In the newborn babies of mothers who are long -term treatment with high doses of anti -anti -anti -anti -anti -anti -anti -drugs - anti -cholin, rarely describe the gastrointestinal signs related to the Atropine properties of phenothiazine (abdominal distention, sloppy rubbing, slow discharge, difficulty breastfeeding, fast heartbeat, neurological disorders ...). Monitoring the nerve and digestive functions of babies for a while.

The period of breastfeeding

When using the cream, the drug is less soaked into the body, so there is no contraindication to use this drug when breastfeeding.

Interactive drug

When using cream, the drug is less absorbed into the body, so it is less likely to occur interactions as reported between oral promethazin and other drugs.

To avoid possible interactions between many drugs, it is necessary to notify the doctor or pharmacist about all other drugs being used.

Storage

Store drugs at 25 ° C - 30 ° C.

Other drugs

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