Philoxim 1g Philox Injection powder Phil Inter Pharma Treatment of infections caused by bacteria strains (10 bottles)

Dosage form 10 bottles box
Specifications Cefotaxim

Ingredient

Composition information	Content
Cefotaxim	1g

Uses

Indications

Philoxim 1g medicine is indicated for infection treatment caused by the sensitive bacterial strains below:

Treatment of lower respiratory tract infections:

Including pneumonia, streptococcus pneumonia, Streptococcus pyogenes* (group A streptococci) and other streptococci (except Enterococci, for example Enterococcus Faecalis), Staphylococcus aureus (strains and non -penicillinase secretions) Klebsiella Species, Haemophilus Influenzae (including ampicillin strains), Haemophilus parainfluenzae, Proteus Mirabilis, Serratia Marcescens*, Entobacter Species, Proteus Indones and Pseudomonas Species (including Aerugosa P.

Treatment of genital tract infections:

Urinary tract infections caused by Enterococcus Species, Staphylococcus Epidermidis, Staphylococcus aureus* (secretions and non -penicillinase), Citrobacter Species, Enterobacter Species, Escherichia Coli, KlebsiLla Special Mirabilis, Proteus Vulgaris*, Providencia Stuartii, Morganella Morganii*, Providencia Rettgeri*, Serratia Marcescens and Pseudomonas Species (including P. Aeruginosa). Gonorrhoeae caused, including penicillinase strains.

Gynecological infection treatment:

includes pelvic inflammatory disease, uterine inflammation, pelvic tissue tissue caused by Staphylococcus Epidermidis, Streptococcus Species, Enterococcus Species, Entobacter Species*, Klebsiella Species*, Escherichia Colili, Proteus Mirabilis, Bacteroids Special (including Bacteroides Fragilis*), Clostridium Species and anaerobic bacteria (including peptostreptococcus species and peptococcus species) and fusobacterium species (including f. nucleatum*) caused. trachomatis.

Treatment of blood infections:

Demonstration caused by Escherichia Coli, Klebsiella Species and Serratia Marcescens, Staphylococcus aureus and Streptococcus Species (including S. Pneumonia).

Philoxim to treat skin infections and skin structure:

Skin infections and skin structure due to staphylococcus aureus (including strains and non -secretion penicillinase), Staphylococcus epidermidis, Streptococcus pyogenes (group A streptococcus) and other streptococcus, Enterococcus species, acinetobacter speces* Coli, Citrobacter Species (including C. Freundii*), Enterobacter Species, Klebsiella Species, Proteus Mirabilis, Proteus Vulgaris*, Morganella Morganii, Provernia Rettgeri*, Pseudomonas Species, Serratia Marcescens, BacteroidES Special, and sphere Anaerobic (including peptostreptococcus* species and peptococcus species).

Treatment of infections in the abdominal cavity:

Includes the peritonitis caused by the Streptococcus Species*, Escherichia Coli, Klebsiella Species, Bacteroides Species, and anaerobic bacteria (including peptostreptococcus* Species and peptococcus* species) Proteus Mirabilis* and ClostiMium Species* caused.

Treatment of bone or joint infections:

Bone or joint infections caused by Staphylococcus aureus (strains and non -secretional secretion), Streptococcus Species (including S. Pyogenes*), Pseudomonas Species (including P. Aeruginosa*) and Proteus Mirabilis*causing.

Nursing:

Meningitis and ventricular ventricular caused by Neisseria Meningitidis, Haemophilus Influenzae, Streptococcus Pneumoniae, Klebsiella Pneumoniae* and Escherichia Coli*.

(*) Effective for this agency, in this system, has been studied less than 10 types of infections.

Preventive: Using Cefotaxim before, during or after surgery may reduce the incidence of infections in patients undergoing surgery (for example, abdominal or gastrointestinal surgery and genital tract) may be infected or infected.

In patients conducting the procedure of opening the uterus and abdominal cavity (after the umbilical cord) and postoperative, using Philoxim may reduce the incidence of postoperative infections at a certain level.

Effective use in selection surgery depends on the time of treatment. To achieve effective drug concentrations in tissue, philoxim should be used 0.5 hours or 1.5 hours before surgery.

For patients undergoing gastrointestinal surgery, preparing bowel before surgery by mechanical cleansing method as well as an absorbing antibiotic (for example, Neomycin) is recommended.

If the patient shows signs of infection, it is necessary to collect culture samples to identify pathogens and conduct appropriate treatment.

To reduce the growth of anti -drug bacteria and maintain the effectiveness of Philoxim and other antibiotics, only use Philoxim in the treatment or prevent infections that have been proven or are more likely to be caused by sensitive bacteria strains.

When there is information about sensitivity and bacterial culture, it is necessary to consider choosing or changing antibacterial therapy. In case there is no information, local sensitive and epidemiological models may contribute to the selection of experience treatment.

Pharmacokological

cefotaxim is the 3rd generation cephalosporin group, with wide antibacterial spectrum. Compared to the cephalosporin of the first and second generations, the cefotaxim has a stronger, more durable gram -negative bacteria for the hydrolysis effect of most beta lactamase. Antibacterial activity of cephalosporins due to the inhibition of mucopeptide synthesis in bacterial cell walls.

pharmacokinetic

cefotaxim is quickly absorbed after intramuscular injection. The average peak concentration in the serum is achieved after 30 minutes another dose of 500mg or 1g Cefotaxim is 12 and 20mcg/ml.

The sale time of cefotaxim is about 1 hour and of activated metabolites desacethylcefotaxim about 1.5 hours.

about 40% Cefotaxim is attached to plasma proteins. Desacetylcefotaxim's waste time is longer than infants and in patients with severe renal impairment. Therefore, it is necessary to reduce the dosage of drugs in these objects.

No dose adjustment in patients with liver disease.

cefotaxim and desacetylcefotaxim are widely distributed in tissues and fluids.

The drug is excreted mainly through the kidneys, about 40% - 60% of the dose is eliminated through urine in the form of non -team in 24 hours.

About 15-25% of the dose is eliminated in the form of Desacetyl derivative.

Before taking Philoxim 1g Philox Injection powder Phil Inter Pharma Treatment of infections caused by bacteria strains (10 bottles)

How to use

Cefotaxim solution used for intravenous or intramuscular injection.

intravenous injection

Dissolve 0.5g of Cefotaxim in 2ml of distilled water mixed or 1g of Cefotaxim in 4ml of distilled water. The mixed solution can be injected from 3 to 5 minutes.

Do not use sodium bicarbonate to mix the injection solution. With intravenous infusion (or higher dose), dissolve 2g cefotaxim in 100ml of 0.9% NaCl solution or 5% glucose solution or separate intravenous injection solution.

Time transmitted from 50 to 60 minutes.

With intravenous infusion in a short time, using 4ml of distilled water injected or one of the above solutions and transmitted for 20 minutes.

Do not use sodium bicarbonate to mix infusion solution in any case.

intramuscularly

Dissolve 0.5g Cefotaxim in 2ml of distilled water injected or 1g Cefotaxim in 4ml of distilled water injected.

The mixed solution should be deep into the body corresponding to the large muscle mass as the outside of the buttocks of the butt (corresponding to the big butt muscle). In a position on the buttocks, not to be injected more than 4ml for adults and not to be injected more than 2ml for children and babies.

Intravenous injection when daily dose exceeds 2g for adults, 100mg/kg/day for children and babies, or in the case of 1G injection more than 2 times a day.

In adults and children over 12 years old, Cefotaxim can be mixed in 1% lidocaine solution (1g in 4ml) to avoid pain when intramuscularly. But this solution is not used for intravenous injection.

Dosage

Adults and children over 12 years old

Dosage and how to use 1G Philoxim is determined based on the sensitivity of the pathogenic bacteria, the severity of the disease and the patient's condition. The maximum daily dose does not exceed 12g.

Status daily dose (g) How to use and sugar Disclosure 2 Intravenous or intravenous 1G every 12 hours.

moderate and severe infection 3 - 6

intramuscularly or intravenously 1g to 2g every 8 hours. hour.

Starting dose of 1g Cefotaxim intravenously immediately after the umbilical grip. The second and third dose are 1g of intramuscular cefotaxim or intravenously after the first dose of 6 hours and 12 hours.

infants and children

Newborn (from 0 - 1 month old):

from 0 - 1 week of age: 50mg/kg per dose, every 12 hours, intravenously.

From 1 - 4 weeks of age: 30mg/kg per dose, every 12 hours, intravenously.

Dosage is the same between newborn babies and monthly babies.

infants and children (from 1 month to 12 years old):

For children with a body weight under 50kg, the recommended dose is 50 - 180mg/kg/day of intramuscular or intravenous injection, divided 4 to 6 times. Higher dosage is used in the treatment of more severe and serious infections, including meningitis.

Children with body weight of 50kg or more using conventional doses in adults, maximum daily dose does not exceed 12g cefotaxim.

Cefotaxim is excreted through the kidneys and the risk of toxic reactions with drugs may be larger in patients with renal failure. Because the elderly often suffer from renal function, it is necessary to be cautious when choosing the dose and need to monitor the patient's kidney function.

Patients with impaired renal function: In patients with creatinine clearance, estimated less than 20ml/min, maintenance dose should be reduced by half. The starting dose is determined based on the sensitivity of the pathogenic bacteria and the severity of the disease.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable Philoxim dose, you need to consult a doctor or medical specialist.

What to do when overdose? Most cases do not manifest clearly toxicity. The common reactions are Bun and Creatinin. Patients with acute overdose should be carefully monitored and conducted treatment measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using 1g Philoxim, you may experience unwanted effects (ADR).

Unwanted effects occur with common frequency (frequency greater than 1%)

Unwanted effects at the injection site (4.3%): inflammation at the injection site when intravenous injection. Pain, hardness and sensitivity at the injection site after intramuscular injection. Symptoms of fake colonitis may appear during or after cefotaxim treatment. Rarely vomiting and nausea occur.

Unwanted effects occur with lower frequencies (less than 1%)

Cardiovascular system: The arrhythmia can be life -threatening after rapid intravenous infusion (less than 60 seconds) through the central venous catheter that has been recorded. Recorded positive COOMB test results in some patients treated with cefotaxim and other cephalosporin antibiotics. Rarely occur hemolytic anemia. Interstitial nephritis and transient bun and creatinin have been recorded.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Philoxim drugs contraindicated in the following cases:

Do not use drugs for patients with hypersensitivity to sodium cefotaxim, or penicillin groups, cephalosporin.

Precautions when using

Caution should be used when using cefotaxim for patients with a history of gastrointestinal diseases, especially colitis.

Subclinical test

Positive COOMB test has been recorded in patients using cephalosporin. This can happen in patients being treated with cefotaxim. The false positive reaction to glucose can occur with other methods, not specific oxidase glucose methods.

Be cautious in using drugs

The injection medications should be carefully tested with the naked eye of strange sub -fertilizers and the discoloration of the drug before use. Dried powdered vials should be stored at temperatures below 30 ° C and avoid light.

Should use the drug immediately after mixing. Do not use the mixed solution after 24 hours.

During storage, the drug solution may be darker. However, the effectiveness and safety of the drug are not changed if the preservatives are guaranteed.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Although animal studies do not record unwanted effects affecting fetal development, the safety of Cefotaxim for pregnant women has not been determined. Therefore, Cefotaxim should not be used for pregnant women, especially in the first three months of pregnancy, unless the benefits of treatment are more important than possible risks.

breastfeeding period

cefotaxim is secreted in breast milk at low concentrations. Be careful when taking medicine for breastfeeding women.

Medicinal interaction

should be cautious when using Cephalosporin antibiotics at high doses along with aminoglycosides or diuretics such as Furosemid due to unwanted kidney effects. However, the dose of Cefotaxim recommends not increasing the toxicity on the kidneys.

cephalosporin and colistin: Used to combine antibiotics of cephalosporin with colistin (antibiotic polymyxin) may increase the risk of kidney damage.

cefotaxim and penicilin: Patients with renal failure may have a brain disease and local epilepsy if using cefotaxim and azlocillin.

cefotaxim and ureaido - penicilin (azlocillin or mezlocillin): simultaneously use these drugs will reduce Cefotaxim clearance in patients with normal kidney function as well as in patients with renal function. Cefotaxim should be reduced if used in combination with those drugs.

cefotaxim increases the toxic effect on the kidneys of cyclosporin.

Storage

In closed containers, cool dry places, avoid light, temperatures below 30 ° C.

The mixed Cefotaxim solution for intravenous or intramuscular injection still works after 24 hours if stored at a temperature of less than 22 ° C, for 10 days if stored in the refrigerator (below 5 ° C).

The mixed Cefotaxim solution for intravenous transmission remains valid for 24 hours if left at a temperature below 22 ° C, within 5 days if stored in the refrigerator (below 5 ° C).

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