Piacledine 300 Hyphens hard capsules treat osteoarthritis and knee joints (1 blister x 15 tablets)

Dosage form Hard capsules
Specifications Box of 1 blister x 15 tablets
Ingredient Complete no saponification avocado and soybean oil
Indication Osteoarthritis, osteoarthritis, gum disease and periodontal disease

Ingredient

Composition information	Content
Complete no saponification avocado and soybean oil	300mg

Uses

Indications

Piacledine 300mg pills are indicated in the following cases:

Faculty of rheumatism: The drug has a slow effect to treat symptoms in hip osteoarthritis and knee joints. Due to the slow impact characteristics, when starting to treat with Piacledine300mg may need to be combined with an NSAID and/or painkillers in doses that can be reduced when the piacledine efficiency is increased.

The mechanism of impact of the whole part of the non -saponification of avocado and soybean oil (ASU) has been assessed through In Vitro and In Vivo research in osteoarthritis (OA) showing the main pharmacological properties as follows:

The main impact mechanism of Piacledine 300mg includes:

The increase in general (PG) Proteoglycans, especially the group has high molecular weight, with the same quality as natural PGs.

Additional effects of two components of piacledine: Inhibiting acute PG and chronic stimulation PG.

Collagen synthesis stimulation by epidemic cells and cartilage cells.

The effect on collagen is due to reducing the inhibition effect of Il-1 and reducing PGE2 synthesis by cartilage cells.

Piascriptine 300mg also inhibits Collagenase II at the joints.

Finally, Piacledine 300mg stimulates the activity of TGFβ1 and TGFβ2 and Plasminogen 1 Activation inhibitors (Pai-1). These effects explain effectively on the recovery and protection of alternate substances.

pharmacokinetics

There is no specialized and accurate analysis method for pharmacokinetic studies for ASU analysis in biological epidemics. Therefore, there is no valuable data on pharmacokinetics of Piacledine 300mg.

Before taking Piacledine 300 Hyphens hard capsules treat osteoarthritis and knee joints (1 blister x 15 tablets)

How to use

Piacledine 300mg pills are taken orally. Avoid chewing tablets and drink with plenty of water.

Dosage

A 300mg capsule a day in the middle of the meal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Piacledine 300mg, you may experience unwanted effects (ADR).

Safety data obtained from clinical studies shows that Piascledine 300mg is not different from placebo. For both treatments, harmful effects on the digestive system are higher than other organs.

Safety data obtained from vigilance shown to be the incidence of harmful effects is very low, lower than 0.08 cases per 1 million days of treatment. In all cases reported, cases and the digestive system are the most often (about 20% of all cases).

Other cases with a relative rate of> 5% include cases in other organs: Skin and subcutaneous tissue disorders, general disorders and medical condition, vascular disorders and nervous system disorders.

Very rare (ADR

Gastrointestinal disorders: diarrhea and epigastric pain.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Piacledine 300mg Piacledine medicine in cases of sensitivity to active ingredients or any excipients of the drug.

Precautions when using

There is no special and cautious warning when used.

Do not use Piacledine 300mg in children and teenagers under 18 years of age because of safety and effectiveness that has not been proven.

Powering and operating machinery

Piascriptine 300mg does not affect the ability to drive or operate machinery.

Pregnancy

on animals: There is no evidence of the monster effect of Piacledine 300mg on animals.

Clinically: Currently, there is no enough data to evaluate the ability to cause defects and fetal toxicity of Piascriptine 300mg. Therefore, avoid using piacledine300mg during pregnancy.

Breastfeeding period

Avoid using Piascriptine 300mg during breastfeeding.

Drug interaction

Not recorded drug interactions for Piascriptine 300mg.

Storage

Store at temperatures below 30ºC. To be out of reach of children.

Other drugs

Disclaimer

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