Picencal Korea Prime prevents and treats osteoporosis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Calcium lactate, calcium gluconate, calcium carbonate, ergocalciferol

Ingredient

Composition information	Content
Calcium lactate	271.8mg
Calcium gluconate	240mg
Calcium carbonate	240mg
Ergocalciferol	0.118mg

Uses

indications

Picenal drugs are indicated in the following cases:

Preventing and treating osteoporosis, reducing the risk of fracture. Using enough calcium is very important in the developing bone period in children and puberty as well as during pregnancy and lactation. Calcium salts play an important role in regulating the absorbent of the cell membrane for Na+ ions and K+ ions, the integrity of the mucosa. Increased calcium concentration decreases permeability and vice versa.

ergocalciferol is vitamin D2. Ergocalciferol has the strongest activity in the vitamin D group, it regulates the metabolism of phosphorus - calcium and bone chemistry and regulates the absorption of phosphorus and amino acids in the renal tubules.

pharmacokinetics

calcium is absorbed in the upper part of the small intestine. In healthy adults, the amount of absorption accounts for about 1/3 of the amount of food. The skeletal system contains 90% of the calcium in the body. In plasma, 40% of calcium in the form of protein, 10% dispersed and complexed with anions such as citrate and phosphate, the rest dispersed in the form of calcium ions. Calcium is excreted through the digestive system such as saliva, bile and pancreatic juice to eliminate through feces.

Calcium is also significantly excreted through breast milk and sweat. Calcium is eliminated in the urine and is related to the excretion of Na+ions. Calcium is reabsorbed in the tube close to the influence of PTH and in the distance under the influence of vitamin D.

Ergocalciferol is well absorbed from the digestive tract, which is then converted in the liver into Calcifediol (25 - Hydroxycholeciferol) and then hydroxy in the kidney into Calcitriol (1.25 - dihydroxololeciferol). Excretion mainly through bile and feces, only a small amount of excretion through urine.

Before taking Picencal Korea Prime prevents and treats osteoporosis (10 blisters x 10 tablets)

How to use

Picenal drug used oral. Best drinking in the morning, before and after 1 hour.

Dosage

The usual dose: 2 capsules/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Severe cases may be comatose, arrhythmia, cardiac arrhyths.

Treatment is aimed at adjusting hypercalcemia: can use oral phosphate, or intravenously in severe cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Picenal, you may experience unwanted effects (ADR).

Unwanted reactions such as digestive disorders (flatulence, diarrhea), anorexia, nausea, vomiting, constipation, stomach pain, hypertension of blood calcium, kidney stones rarely occur.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Picenal medicine is contraindicated in the following cases:

allergies to the composition of the drug.

Be cautious when using

Precautions when indicated for the following patients:

Patients who are taking vitamin D.

Monitor calcium urinary tract during prolonged treatment.

sarcoidosis or parathyroidism (can cause increased sensitivity to vitamin D); renal function; heart disease; Kidney stones; atherosclerosis.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

drugs that are not harmful when using the right dose according to usual daily needs. However, pregnant women should be provided with calcium by adequate diet. Use too many vitamins and calcium and other minerals that can be harmful to the mother or fetus.

The period of breastfeeding

is not harmful when using the daily dosage daily.

Drug interaction

picenal tablet inhibits the absorption of tetracyclin. Therefore, picenal tablet should not be used simultaneously with tetracyclin antibiotics.

Do not treat vitamin D simultaneously with cholestyramine or colestipol hydrochloride, as it can lead to reducing the absorption of vitamin D in the intestine. Excessive use of mineral oil can hinder the absorption of vitamin D in the intestine.

Simultaneous treatment of vitamin D with diuretic gums for people with parathyroidism can lead to hypercalcemia. In that case, it is necessary to reduce the dosage of vitamin D or stop taking vitamin D temporarily. Using thiazid diuretics in those who are parathyroidism causing hypercalcemia is probably due to bone release from bone release.

Do not simultaneously use vitamin D with phenobarbital and/or phenytoin (and may be with other drugs that cause liver enzymes) because these drugs can reduce concentration 25 - hydroxyergocalciferol and 25 - hydroxy - colecalciferol in plasma and increase vitamin D into non -active substances.

Do not simultaneously use vitamin D with corticosteroids because corticosteroids hinder the effect of vitamin D.

Do not simultaneously use vitamin D with cardiac glycosides because of the toxicity of glycosides that support cardiac increased due to hypercalcemia, leading to arrhythmia.

Storage

Store at a temperature not exceeding 30 ° C.

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